In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19094-56-5 as follows. Safety of 2-Chloro-5-iodobenzoic acid
5-iodoaniline-2-chlorobnenzoic acid 3. 3g soln. ethanol 150 ml, concentrated hydrochloric acid 0. 11g is added, heated under reflux for 12 hours. After returning the reaction solution to room temperature, is diluted with water, adding an aqueous solution of sodium hydroxide 1N, 3 times extracted with ethyl acetate. The organic layer, washed with saturated saline solution, dried with magnesium sulfate waterlessly org. layer. By concentrating the pressure somas, 5-iodoaniline-2-ethyl chlorobnenzoic (43) 1. 74g is obtained.
According to the analysis of related databases, 19094-56-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; OAT AGRIO COMPANY LIMITED; UENAKA, GO; MASUMOTO, SATORU; HAYASHI, NAOTAKA; (63 pag.)JP5743418; (2015); B2;,
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