Synthetic Route of 2974-94-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2974-94-9 name is 1-Iodo-4-phenoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound 4: 25 mL reaction flask was charged with 4-phenoxyiodobenzene (0.5 mmol), 3-ethoxyphenylboronic acid (0.75 mmol), sodium carbonate (1.0 mmol), and cesium hydroxide monohydrate (2.5 mmol), sodium iodide (0.25 mmol), pivalic acid (0.75 mmol), chloroform (1.5 mmol) and ethylene glycol (2.0 g). Reacted at 120 C for 24 h. Cool to room temperature, extract, the solvent was evaporated under reduced pressure and then purified by column chromatography to yield a yield of 92%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Iodo-4-phenoxybenzene, and friends who are interested can also refer to it.
Reference:
Patent; Nanjing Normal University; Han Wei; Xu Fangning; (15 pag.)CN108774122; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com