The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Solid state properties and effective resolution procedure for guaifenesin, 3-(2-methoxyphenoxy)-1,2-propanediol, the main research direction is guaifenesin enantiomer resolution.HPLC of Formula: 60827-45-4.
Racemic expectorant guaifenesin, 3-(2-methoxyphenoxy)-1,2-propanediol (2) undergoes spontaneous resolution upon crystallization This fact is confirmed by thermal anal. (single eutectic V-shape binary melting phase diagram, adequate entropy and free energy characteristics). Racemic 2 could be effectively resolved into (S)- and (R)-2 by a preferential crystallization procedure. Single enantiomer drugs levomoprolol and levotensin were obtained by starting from enantiomeric 2 through the sulfite route.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com