The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.Name: (2S)-(+)-3-Chloropropane-1,2-diol.Ford, W. C. L.; Harrison, Anne; Waites, G. M. H. published the article 《Effects of the optical isomers of α-chlorohydrin on glycolysis by ram testicular spermatozoa and the fertility of male rats》 about this compound( cas:60827-45-4 ) in Journal of Reproduction and Fertility. Keywords: chlorohydrin sperm glycolysis fertility. Let’s learn more about this compound (cas:60827-45-4).
When 0.1 mM S-α-chlorohydrin [60827-45-4] was present in incubations, glycolysis by ram testicular spermatozoa was almost completely inhibited whereas 10 mM R-α-chlorohydrin [57090-45-6] had no effect. Male rats dosed orally with S-α-chlorohydrin (3.25 mg/kg/day) became much less fertile than controls but those dosed with R-α-chlorohydrin (13 mg/kg/day) did not. The loss of fertility was associated with a reduced ability of spermatozoa from the cauda epididymidis of these rats to oxidize glucose [50-99-7]. Apparently, the S enantiomer is responsible for both the inhibition of sperm glycolysis and the reduction in fertility caused by the racemic mixture of α-chlorohydrin.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com