The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol.Lok, C. M.; Ward, J. P.; Van Dorp, D. A. published the article 《The synthesis of chiral glycerides starting from D- and L-serine》 about this compound( cas:60827-45-4 ) in Actes Congr. Mond. – Soc. Int. Etude Corps Gras, 13th. Keywords: glyceride chiral synthesis serine. Let’s learn more about this compound (cas:60827-45-4).
Chiral glycerides were prepared starting from D- and L-serine by a multistep stereospecific sequence. E.g., L-serine was converted by diazotization and esterification into Me L-glycerate, this by acetalization and reduction to 2,3-O-isopropylidene-sn-glycerol, which was converted by sequential chlorination, hydrolysis, and cyclocondensation to D-glycidol (I). I could be acylated, then esterified with a fatty acid to give a diglyceride mixture, which could be isomerized by heating to 100% 1,3-diglycerides, or its hydroxyl group could be protected by a trityl group and it could be converted into a 1,2-diglyceride. Both types of diglycerides could be converted conventionally into sn-triglycerides.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com