So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jiang, Chengjun; Hong, Huabin researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《A new practical synthesis of ethyl (R)-(-)-4-cyano-3-hydroxybutyrate from (S)-3-chloro-1,2-propanediol》 about this compound( cas:60827-45-4 ) in Letters in Organic Chemistry. Keywords: cyanohydroxybutyrate atorvastatin precursor asym synthesis. We’ll tell you more about this compound (cas:60827-45-4).
A practical chem. synthesis of (R)-4-cyano-3-hydroxybutyrate was accomplished starting from (S)-3-chloro-1,2-propanediol, which is the main byproduct originating from (S,S)-salen Co(III)-catalyzed hydrolytic kinetic resolution of epichlorohydrin. The new synthetic approach demonstrated an efficient utilization of organic byproduct for the asym. synthesis of the intermediate of atorvastatin.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com