Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. COA of Formula: C6H6IN.
Gagne-Boulet, Mathieu;Bouzriba, Chahrazed;Chavez Alvarez, Atziri Corin;Fortin, Sebastien research published 《 Phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonates and phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonamides as new antimicrotubule agents targeting the colchicine-binding site》, the research content is summarized as follows. Herein, 15 new Ph 4-(2-oxopyrrolidin-1-yl)benzenesulfonate (PYB-SO) and 15 Ph 4-(2-oxopyrrolidin-1-yl)benzenesulfonamide (PYB-SA) derivatives, I [X = O, NH; R = H, 2-iso-Pr, 4-Ph, etc.] were designed, prepared, chem. characterized, biol. evaluated and the effect of pyrrolidin-2-one moiety was also evaluated. Compounds I exhibited antiproliferative activity in the low nanomolar to low micromolar range (0.0087-8.6μM and 0.056-21μM, resp.) on human HT-1080, HT-29, M21 and MCF7 cancer cell lines. Moreover, they block cell cycle progression in G2/M phase. Immunofluorescence, tubulin affinity and tubulin polymerization assays showed that they cause microtubule depolymerization by docking the C-BS. In addition, docking assays with the most potent derivatives showed binding affinity toward the C-BS and they also exhibited weak or no toxicity toward chick embryos. Finally, physicochem. properties calculated using the SwissADME algorithm showed that PYB-SOs and PYB-SAs I were promising new families of antimicrotubule agents.
626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.
3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., COA of Formula: C6H6IN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com