《Gold (I/III)-Catalyzed Trifluoromethylthiolation and Trifluoromethylselenolation of Organohalides》 was written by Mudshinge, Sagar R.; Yang, Yuhao; Xu, Bo; Hammond, Gerald B.; Lu, Zhichao. Product Details of 626-02-8This research focused ontrifluoromethyl thioether preparation; silver trifluoromethanethiolate organohalide trifluoromethylthiolation gold redox catalyst; selenoether trifluoromethyl preparation; tetramethylammonium trifluoromethylselenate organohalide trifluoromethylselenolation gold redox catalyst; Cross-Coupling; Gold Catalysis; Organohalides; Trifluoromethylselenolation; Trifluoromethylthiolation. The article conveys some information:
The first C-SCF3/SeCF3 cross-coupling reactions using gold redox catalysis [(MeDalphos)AuCl], AgSCF3 or Me4NSeCF3, and organohalides ArI (Ar = Ph, 4-bromophenyl, 2,6-dimethoxypyridin-3-yl, ec.), (E/Z)-RCH=CHI (R = C(O)OMe, Ph, naphthalen-1-yl, etc.) and R1CCBr (R1 = Ph, 4-fluorophenyl, 4-nitrophenyl, etc.) as substrates are reported. The new methodol. enables a one-stop shop synthesis of aryl/alkenyl/alkynyl trifluoromethylthio- and selenoethers ArSCF3, (E/Z)-RCH=CHSCF3, R1CCSCF3, and RSeCF3 with a broad substrate scope (>60 examples with up to 97% isolated yield). The method is scalable, and its robustness is evidenced by the late-stage functionalization of various bioactive mols., which makes this reaction an attractive alternative in the synthesis of trifluoromethylthio- and selenoethers for pharmaceutical and agrochem. research and development. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8Product Details of 626-02-8)
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Product Details of 626-02-8 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com