Singh, Prabhakar; Arulananda Babu, Srinivasarao; Aggarwal, Yashika; Patel, Pooja published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Pd(II)-catalyzed, Picolinamide-aided sp2 γ-C-H Functionalization of Phenylglycinol: Access to γ-C-H Arylated, Alkylated and Halogenated Phenylglycinol Scaffolds》.HPLC of Formula: 625-99-0 The article contains the following contents:
The Pd(II)-catalyzed picolinamide-aided ortho-C-H arylation-, alkylation-, and halogenation (sp2 γ-C-H functionalization) of phenylglycinol substrates was reported. Phenylglycinols I [R = Ph, 4-BrC6H4, 4-MeC6H4, etc.; R1 = 2-pyridinecarboxamidyl; stereo = R, S, no stereo] were remarkable building blocks and have found different applications in synthetic organic and medicinal chem. This work was a contribution toward the expansion of the library of phenylglycinol scaffolds and also substrate scope development by using the Pd(II)-catalyzed bidentate directing group picolinamide-aided C-H activation tactic. The experimental part of the paper was very detailed, including the reaction process of 1-Chloro-3-iodobenzene(cas: 625-99-0HPLC of Formula: 625-99-0)
1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.HPLC of Formula: 625-99-0
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com