Zhou, Zebiao; Huang, Bin; Cai, Mingzhong published an article in 2021. The article was titled 《Recyclable palladium-catalyzed carbonylative annulation of 2-iodoanilines with acid anhydrides: A practical synthesis of 2-alkylbenzoxazinones》, and you may find the article in Synthetic Communications.Formula: C6H5ClIN The information in the text is summarized as follows:
A highly efficient heterogeneous palladium-catalyzed carbonylative annulation of 2-iodoanilines and acid anhydrides was developed. The reaction proceeded effectively in toluene using N,N-diisopropylethylamine (DIPEA) as the base at 100°C under 2 bar of CO and provided a novel, general and practical method for the assembly of a wide variety of benzoxazinones with high functional group tolerance and good to excellent yields. This supported palladium complex was readily separated from the product and recovered by a simple filtration of the reaction solution and reused up to seven times with almost consistent catalytic efficiency.4-Chloro-2-iodoaniline(cas: 63069-48-7Formula: C6H5ClIN) was used in this study.
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Formula: C6H5ClIN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com