In 2019,Advanced Synthesis & Catalysis included an article by Lu, Hao; Li, Zheng. Safety of 1-Chloro-3-iodobenzene. The article was titled 《Palladium-Catalyzed One-Pot Four-Component Synthesis of β-Cyano-α,β-unsaturated Ketones Using Calcium Carbide as an Acetylene Source and Potassium Hexacyanoferrate(II) as an Eco-Friendly Cyanide Source》. The information in the text is summarized as follows:
Palladium-catalyzed one-pot four-component synthesis of β-cyano-α,β-unsaturated ketones (Ar)(CN)C=CH(C(O)Ar1) [Ar = Ph, 4-MeC6H4, 2-FC6H4, etc.; Ar1 = Ph, 3-BrC6H4, 4-F3CC6H4, etc.] was reported via reaction of aryl halides, calcium carbide, potassium hexacyanoferrate(II) and aroyl chlorides. The salient features of this protocol were the direct use of easy-to-handle acetylene source and eco-friendly cyanide source, wide scope of substrates with good functional group tolerance and simple work-up procedure. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0Safety of 1-Chloro-3-iodobenzene)
1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 1-Chloro-3-iodobenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com