In 2022,Zhang, Kan; Yang, Mingming; Yao, Yanxiu; Yu, Binxun; Wang, Yanyan; Sun, Huaming; Zhang, Weiqiang; Zhang, Guofang; Gao, Ziwei published an article in New Journal of Chemistry. The title of the article was 《One-pot synthesis of benzo[b][1,4]diazepines via the carbonylative Sonogashira reaction and aza-Michael addition cyclocondensation》.Synthetic Route of C6H4ClI The author mentioned the following in the article:
A highly efficient synthetic method for benzodiazepines was reported, which involved a ppm-level Pd-catalyzed carbonylative coupling of iodobenzenes with terminal alkynes to afford 1,3-ynones as key intermediates and a subsequent Cp2TiCl2/m-phthalic acid/ethanol-catalyzed cyclocondensation in one-pot conditions. The new approach proceeded with a broad substrate scope under mild reaction conditions, provided benzo[b][1,4]diazepines in up to 90% yield. The experimental process involved the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Synthetic Route of C6H4ClI)
1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Synthetic Route of C6H4ClI Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com