Li, Renhe published the artcileRedox-Neutral Vicinal Difunctionalization of Five-Membered Heteroarenes with Dual Electrophiles, Synthetic Route of 165534-79-2, the publication is Angewandte Chemie, International Edition (2021), 60(50), 26184-26191, database is CAplus and MEDLINE.
A new reaction mode of palladium/norbornene (Pd/NBE) cooperative catalysis is reported involving the selective coupling of two different carbon-based electrophiles for vicinal double C-H functionalization of five-membered heteroarenes in a site-selective and redox-neutral manner. The key is to use alkynyl bromides as the second electrophile, which allows vicinal difunctionalization of a wide range of heteroarenes including pyrroles, thiophenes and furans at their C4 and C5 positions [e.g., 2-chloro-1-methylpyrrole + Me 2-iodobenzoate + Br-CîC-TIPS â?I (78%)]. One- or two-step tetrafunctionalizations of simple pyrrole and thiophene have also been realized. The C2-substituted NBEs prove most effective in these reactions, and the mechanistic exploration discloses the origin of the high selectivity of this transformation. Synthetic utility of this method has been exemplified in the concise preparations of thiophene-containing organic materials and a protein kinase inhibitor analog. Preliminary success has also been achieved in a direct annulation event, using a tethered ketone as the second electrophile.
Angewandte Chemie, International Edition published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Synthetic Route of 165534-79-2.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com