Gunaratna, Medha J. published the artcileSynthesis of probe molecules, 6-(dimethylamino)-2-phenylisoindolin-1-ones, for mechanistic studies of firefly luciferase inhibition, Application of (2-Amino-5-iodophenyl)methanol, the publication is Heterocycles (2021), 103(1), 231-248, database is CAplus and MEDLINE.
In order to probe firefly luciferase inhibition’s mechanism, we synthesized two probe mols. I and II, mimicking F-53. Mol. I contains an azido-appended side chain in the aromatic ring of F-53, while 2 possesses an azido and a carboxylic acid group appended side chains. Both synthetic schemes are readily amenable to large-scale syntheses. Mol. I was made from 2-allylaniline, which was derived from a thermal-induced aromatic-Claisen rearrangement of N-allylaniline. The azido-appended side chain of II was installed from a Horner-Wadsworth-Emmons reaction and the carboxylic acid side chain from a Sonogashira reaction.
Heterocycles published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Application of (2-Amino-5-iodophenyl)methanol.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com