Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach was written by Dwyer, Michael P.;Keertikar, Kartik;Paruch, Kamil;Alvarez, Carmen;Labroli, Marc;Poker, Cory;Fischmann, Thierry O.;Mayer-Ezell, Rosemary;Bond, Richard;Wang, Yan;Azevedo, Rita;Guzi, Timothy J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Quality Control of 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine This article mentions the following:
The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit to the identification of a series of potent, pan-Pim inhibitors such as I are described. In the experiment, the researchers used many compounds, for example, 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine (cas: 923595-58-8Quality Control of 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine).
5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine (cas: 923595-58-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Quality Control of 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com