Palladium-catalyzed Catellani-type couplings using methylating reagents for the synthesis of highly substituted ortho-methyl-arenes and heteroarenes was written by Wilson, Jonathan E.. And the article was included in Tetrahedron Letters in 2016.Product Details of 153034-88-9 This article mentions the following:
The incorporation of a Me group into a small mol. can have a profound impact on its biol. activity, pharmacokinetic profile, and phys. properties. As part of an ongoing effort to develop novel methods for methylation of small mol. drug candidates, a three-component coupling of aryl iodides, O-benzoylamines, and methylboronic acid that proceeds via a Catellani-type mechanism has been developed. The methodol. allows for the ortho-amination/ipso-methylation of aryl- and heteroaryl iodides with a wide variety of cyclic O-benzoylamines including pyrrolidines, piperidines, piperazines, morpholines, azepines, diazepines, and azocanes in a single step. A preliminary result for an ortho-methylation/ipso-olefination Catellani-type three component-coupling reaction is also described. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-iodo-3-methylpyridine (cas: 153034-88-9Product Details of 153034-88-9).
2-Chloro-4-iodo-3-methylpyridine (cas: 153034-88-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Product Details of 153034-88-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com