Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor was written by Liu, Gang;Xin, Zhili;Pei, Zhonghua;Hajduk, Philip J.;Abad-Zapatero, Cele;Hutchins, Charles W.;Zhao, Hongyu;Lubben, Thomas H.;Ballaron, Stephen J.;Haasch, Deanna L.;Kaszubska, Wiweka;Rondinone, Cristina M.;Trevillyan, James M.;Jirousek, Michael R.. And the article was included in Journal of Medicinal Chemistry in 2003.Recommanded Product: 1-Fluoro-2-iodo-4-methylbenzene This article mentions the following:
Using an NMR-based fragment screening and x-ray crystal structure-based assembly, starting with millimolar ligands for both the catalytic site and the second phosphotyrosine binding site, we have identified a small-mol. inhibitor of protein tyrosine phosphatase 1B with low micromolar inhibition constant, high selectivity (30-fold) over the highly homologous T-cell protein tyrosine phosphatase, and good cellular activity in COS-7 cells. In the experiment, the researchers used many compounds, for example, 1-Fluoro-2-iodo-4-methylbenzene (cas: 452-82-4Recommanded Product: 1-Fluoro-2-iodo-4-methylbenzene).
1-Fluoro-2-iodo-4-methylbenzene (cas: 452-82-4) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 1-Fluoro-2-iodo-4-methylbenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com