An efficient one-pot synthesis of annulated pyridines utilizing a directed ortho-metalation/transmetalation approach was written by Davies, Antony J.;Brands, Karel M. J.;Cowden, Cameron J.;Dolling, Ulf-H.;Lieberman, David R.. And the article was included in Tetrahedron Letters in 2004.COA of Formula: C4H8ClI This article mentions the following:
The ortho-alkylation of Boc-protected aminopyridines with α,ω-dihaloalkanes followed by in situ cyclization, resulted in the corresponding annulated pyridine derivatives in good to excellent yields. The effect of the alkylating and chelating agents, the transmetalation additives and the directing group was examined In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9COA of Formula: C4H8ClI).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.COA of Formula: C4H8ClI
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com