Ma, Chunrong et al. published their research in Journal of Organic Chemistry in 2001 | CAS: 220185-63-7

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.HPLC of Formula: 220185-63-7

Efficient Asymmetric Synthesis of Biologically Important Tryptophan Analogues via a Palladium-Mediated Heteroannulation Reaction was written by Ma, Chunrong;Liu, Xiaoxiang;Li, Xiaoyan;Flippen-Anderson, Judith;Yu, Shu;Cook, James M.. And the article was included in Journal of Organic Chemistry in 2001.HPLC of Formula: 220185-63-7 This article mentions the following:

A novel and concise synthesis of optically active tryptophan derivatives was developed via a palladium-catalyzed heteroannulation reaction of substituted o-iodoanilines with an internal alkyne. The required internal alkyne I was prepared in greater than 96% diastereomeric excess via alkylation of the Schollkopf chiral auxiliary, 3,6-diethoxy-2R-isopropyl-2,5-dihydropyrazine with Me3SiCCCH2OP(:O)(OPh)2. Similarly, alkyne II was obtained from the alkylation of 3,6-diethoxy-2S-isopropyl-2,5-dihydropyrazine by TMSCCCH2OP(:O)(OPh)2. I was used as an intermediate in the palladium-catalyzed heteroannulation reaction to afford L-tryptophan analogs, whereas II afforded D-tryptophan analogs. Using this strategy, the first asym. syntheses of L-isotryptophan (III) and L-benz[f]tryptophan (IV) were realized. In addition, the optically pure Et 6-methoxy-D-tryptophanate (V) was prepared by this protocol on a large scale (>300 g). An improved total synthesis of tryprostatin A (VI) was accomplished in 43% overall yield employing this palladium-mediated process. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7HPLC of Formula: 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.HPLC of Formula: 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com