5029-67-4 Archives - Page 6 of 10 - Iodides-buliding-blocks

Lokolkar, Manjunath S. team published research in Applied Organometallic Chemistry in 2021 | 5029-67-4

Quality Control of 5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. Quality Control of 5029-67-4.

Lokolkar, Manjunath S.;Mane, Pravin A.;Dey, Sandip;Bhanage, Bhalchandra M. research published 《 Xantphos-coordinated palladium dithiolates: highly efficient catalysts for decarboxylative Sonogashira reaction into corresponding alkynes》, the research content is summarized as follows. Synthesis and application of xantphos-coordinated palladium dithiolate complexes as catalysts for decarboxylative Sonogashira coupling reaction of phenylpropiolic acid and 2-butynoic acid with various iodoarenes are reported. The effect of various functional groups on the yield of corresponding heteroaryl alkynes has been explored. The current protocol showed excellent catalytic activity of the synthesized complexes towards decarboxylative alkynylation reaction with high turn-over number (TON) up to 105 and turn-over frequency (TOF) up to 104 h^-1. The catalyst could be recycled up to six times without losing its catalytic activity. The in situ generation of palladium nanoparticles (PdNPs) was observed after the third recycle, and the amount was significant after the sixth recycle. The catalytic activity of the reaction is attributed to the formation of PdNPs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Yong team published research in Organic Chemistry Frontiers in 2022 | 5029-67-4

5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., COA of Formula: C5H4IN

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. COA of Formula: C5H4IN.

Liu, Yong;Xing, Shuya;Zhang, Jing;Liu, Wen;Xu, Yuenian;Zhang, Yan;Yang, Kefang;Yang, Lei;Jiang, Kezhi;Shao, Xinxin research published 《 Construction of diverse C-S/C-Se bonds via nickel catalyzed reductive coupling employing thiosulfonates and a selenosulfonate under mild conditions》, the research content is summarized as follows. A nickel-catalyzed reductive cross coupling between organic iodides and thiosulfonates and a selenosulfonate under mild conditions was disclosed. This practical method provides a facile access to a series of unsym. thioethers with low catalyst loading, good functional group tolerance, and excellent chemo-selectivity. Notably, the synthetic applications of the approach feature scaling-up of reactions, late-stage modification of pharmaceuticals, and preparation of various useful targeted compounds, including sulfoximine, bipyridine, and vortioxetine. Primary mechanistic studies showed that a radical pathway was involved. Moreover, diverse C-S/C-Se bond formations were achieved under mild reaction conditions.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Si-Zhan team published research in Tetrahedron Letters in 2021 | 5029-67-4

Electric Literature of 5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Liu, Si-Zhan;Li, Jing;Xue, Cao-Gen;Xu, Xue-Tao;Lei, Lin-Sheng;Huo, Chen-Yu;Wang, Zhen;Wang, Shao-Hua research published 《 Copper-promoted cyanation of aryl iodides with N,N-dimethyl aminomalononitrile》, the research content is summarized as follows. A copper-promoted cyanation of aryl iodides was successfully developed by using N,N-di-Me aminomalononitrile as the cyanide source with moderate toxicity and better stability. The reaction featured broad substrate scope, excellent reaction yields, readily available catalyst, and simple reaction conditions.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liedtke, Rene team published research in Helvetica Chimica Acta in 2021 | 5029-67-4

Product Details of C5H4IN, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Product Details of C5H4IN.

Liedtke, Rene;Surmiak, Sabrina;Jie, Xiaoming;Daniliuc, Constantin G.;Kehr, Gerald;Erker, Gerhard research published 《 Ring Construction by 1,1-Carboboration; Making Anthracene Derivatives from a Tetra(alkynyl)benzene》, the research content is summarized as follows. 1,2,4,5-Tetrakis(trimethylsilylethynyl)benzene reacted with two molar equivalents of the boranes R-B(C₆F₅)₂ (R=C₆F₅, Me, Ph) in a series of sequential 1,1-carboboration reactions to give ca. 1 : 1 mixtures of the two-fold benzannulated products, namely the resp. C_2h and C_2v sym. tetra-silyl, bis-boryl substituted anthracenes. Their active B(C₆F₅)₂ substituents were used for consecutive Suzuki-Miyaura C-C coupling reactions to give boron-free Ph or 2-pyridyl substituted anthracene products.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Zhaojie team published research in Chemistry – An Asian Journal in 2022 | 5029-67-4

Recommanded Product: 2-Iodopyridine, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Li, Zhaojie;Shen, Jie;Jiang, Qing;Shen, Sheng;Zhou, Jing;Zeng, Huaqiang research published 《 Directionally Aligned Crown Ethers as Superactive Organocatalysts for Transition-metal Ion-free Arylation of Unactivated Arenes》, the research content is summarized as follows. When one-dimensionally aligned to the same side, multiple non-covalently associated crown ether groups could act as a whole to yield a higher catalytic activity than an individual poorly active crown ether group, delivering the lowest catalyst loading of 1-2 mol among all hitherto known organocatalysts for catalyzing direct arylation of inactivated arenes such as benzene, 1,4-difluorobenzene, pyridine and pyrazine with iodoarenes ArI (Ar = Ph, naphthalen-2-yl, thiophen-3-yl, etc.).

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Xue-Hong team published research on Organic & Biomolecular Chemistry in 2021 | 5029-67-4

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. SDS of cas: 5029-67-4.

Li, Xue-Hong;Gong, Jun-Fang;Song, Mao-Ping research published 《 Diastereoselective synthesis of chiral 3-substituted isoindolinones via rhodium(III)-catalyzed oxidative C-H olefination/annulation》, the research content is summarized as follows. A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(III)-catalyzed chiral N-sulfinyl amide directed asym. [4 + 1] annulation of benzamides with acrylic esters has been developed. The reaction proceeded through an oxidative C-H olefination and a subsequent cyclization by intramol. aza-Michael addition, producing a series of diastereoisomeric chiral isoindolinones (20 examples) in generally good yields with a dr value up to 5.5 : 1. The absolute configurations of the newly formed C-stereocenters in the major and minor diastereomers of the catalysis product have been determined by X-ray crystal diffraction anal. to be S and R, resp. The separation of the major diastereoisomers from the catalysis products and subsequent removal of the N-sulfinyl chiral auxiliary afforded enantiomerically pure (S)-isoindolinones. The application of the obtained (S)-isoindolinones in the synthesis of several biol. active isoindolinones such as (S)-PD172938, (S)-pazinaclone and (S)-pagoclone is presented.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lee, Jaehee team published research on Organic Letters in 2022 | 5029-67-4

Lee, Jaehee;Ju, Xuan;Lee, Miseon;Jiang, Qi;Jang, Hwanjong;Kim, Wan Shin;Wu, Linglin;Williams, Suja;Wang, Xiao-Jun;Zeng, Xingzhong;Payne, Jenna;Han, Zhengxu S. research published 《 Copper Catalyzed Regioselective and Stereospecific Aziridine Opening with Pyridyl Grignard Nucleophiles》, the research content is summarized as follows. Copper catalyzed regioselective and stereospecific coupling between aziridines and in-situ generated pyridine Grignard reagents was reported. This method provided β-pyridylethylamines with diverse structures and functionalities from aziridines and iodopyridines. The β-pyridylethylamines were potential scaffolds for the synthesis of biol. active compounds often found in pharmaceuticals. The synthesis of challenging chiral dihydroazaindoles was also achieved through mild one-pot reaction conditions via aziridine opening followed by nucleophilic cyclization.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Hongfang team published research on Organic Letters in 2022 | 5029-67-4

Li, Hongfang;Khan, Ijaz;Li, Qun;Zhang, Yong Jian research published 《 Pd-Catalyzed Asymmetric Three-Component Allenol Carbopalladation and Allylic Cycloaddition Cascade: A Route to Functionalized Tetrahydrofurans》, the research content is summarized as follows. The first Pd-catalyzed asym. three-component reaction of 2,3-allenol, aryl iodides RI (R = 4-methoxyphenyl, 2H-1,3-benzodioxol-5-yl, thiophen-2-yl, etc.) and 2-arylmethylenemalononitriles R¹CH=C(CN)₂ (R¹ = 2-methylphenyl, 2H-1,3-benzodioxol-5-yl, furan-2-yl, etc.) has been developed via an allenol carbopalladation and an allylic cycloaddition cascade. This process allows rapid access to substituted tetrahydrofurans I bearing diverse functional groups in good yields with high diastereoselectivities and excellent enantioselectivities. The concise total synthesis of a lignan, (-)-2-episesaminone, has been achieved by the elaboration of a functionalized THF obtained from this reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Kejie team published research on CCS Chemistry in 2022 | 5029-67-4

COA of Formula: C5H4IN, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Li, Kejie;Wang, Ming;Jiang, Xuefeng research published 《 Full-spectrum fluoromethyl sulfonation via modularized multicomponent coupling》, the research content is summarized as follows. Modular free-assembly construction of mono-, di-, and tri-fluoromethyl sulfones was comprehensively achieved by a combination of halides, a sulfur dioxide surrogate, and halofluorocarbons. The industrial raw material thiourea dioxide served as the sulfur dioxide source, combined with readily available fluorocarbon sources such as 2-bromo-2-fluoroacetate and chlorodifluoromethane employed as fluoromethyl reagents. Notably, four Me sulfone-containing pharmaceuticals were modified into three types of fluoromethyl sulfones, displaying their great potential for drug discovery via the current strategy. Mechanistic studies further demonstrated that C-F···H-N interactions between thiourea dioxide and halofluorocarbons play a key role in stabilizing monofluoromethyl electrophiles and difluorocarbene species.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Xiong team published research on Advanced Synthesis & Catalysis in 2020 | 5029-67-4

Li, Xiong;Xu, Jie;Li, Yue;Kramer, Soeren;Skrydstrup, Troels;Lian, Zhong research published 《 Silylcarboxylic Acids as Bifunctional Reagents: Application in Palladium-Catalyzed External-CO-Free Carbonylative Cross-Coupling Reactions》, the research content is summarized as follows. A palladium-catalyzed external-CO-free carbonylative Hiyama-Denmark cross-coupling reaction is presented. The introduction of silylcarboxylic acids I (R = 4-Me, 3-Me, 2-Me, 4-tert-butyl) as bifunctional reagents (CO and nucleophile source) avoids the need for external gaseous CO and a silylarene coupling partner. The transformation features high functional group tolerance and it is successful with electron-rich, -neutral, and -poor aryl iodides ArI (Ar = 4-methoxyphenyl, naphthalen-1-yl, thiophen-3-yl, etc.). Stoichiometric studies and control experiments provide insight into the reaction mechanism and support the hypothesized dual role of silylcarboxylic acids.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com