Category: 60827-45-4

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Catalytic behavior of wool-osmium tetroxide complex for asymmetric dihydroxylation of olefins, published in 2004-04-30, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Reference of (2S)-(+)-3-Chloropropane-1,2-diol.

A new chiral polymer-metal complex, wool-osmium tetroxide (wool-OsO4) complex was prepared by a very simple method. This complex was able to catalyze the asym. dihydroxylation of allylamine to (R)-(+)-3-amino-1,2-propanediol and allyl chloride to (S)-(+)-3-chloro-1,2-propanediol. The optical yields amounted to 83.7 and 57.2%, and the product yields were 80.2 and 68.5% resp. The exptl. results showed that OsO4 content in the complex, reaction time, allylamine/OsO4 molar ratio and solvent all have an effect on the product and optical yields. Addnl., wool-OsO4 complex catalyst could be reused without any remarkable change in optical catalytic activity.

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Velisek, Jan; Ledahudcova, Katerina; Hajslova, Jana; Pech, Pavel; Kubelka, Vladislav; Viden, Ivan published the article 《New 3-chloro-1,2-propanediol derived dihydroxypropylamines in hydrolyzed vegetable proteins》. Keywords: hydroxypropylamine vegetable protein hydrolyzate; ammonia chloropropanediol reaction; soybean hydrolyzate hydroxypropylamine.They researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Formula: C3H7ClO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:60827-45-4) here.

Reaction products of 3-chloro-1,2-propanediol (the main contaminant of protein hydrolyzates produced by HCl hydrolysis and used as food seasonings) with ammonia in model aqueous solutions were analyzed, and in addition to the known compounds (glycerol, 3-amino-1,2-propanediol, 2-amino-1,3-propanediol), bis(2,3-dihydroxypropyl)amine and tris(2,3-dihydroxypropyl)amine were newly identified. A soybean meal hydrolyzate containing >400 mg/kg 3-chloro-1,2-propanediol, and an alkali-treated hydrolyzate containing <1 mg/kg 3-chloro-1,2-propanediol were analyzed, and bis(2,3-dihydroxypropyl)amine (in concentrations of 6 and 3 mg/kg, resp.) and tris(2,3-dihydroxypropyl)amine (2 and 4 mg/kg, resp.) were identified as components of these com. seasonings. Mass spectra of the silyl derivatives and 1H and 13C NMR spectra of these newly found compounds in foods are presented. There are many compounds similar to this compound(60827-45-4)Formula: C3H7ClO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

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Iodide – Wikipedia,
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SDS of cas: 60827-45-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about 4(2)-Methoxyphenyl glycerol ethers in the synthesis of non-racemic di-O,O-acylglycerols.

Effective methods for the synthesis of non-racemic 4- and 2-methoxyphenyl glycerol ethers from non-racemic 3-chloropropanediols and by direct resolution of the racemate, resp., were developed. Some existing discrepancies related to the to chiroptical properties of their derivatives were eliminated. Both ethers were used to synthesize non-racemic 3-O-aryloxy-1,2-di-O’,O”-palmitoyl glycerols.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Chemistry & Industry (London, United Kingdom) called Stereospecific synthesis of R- and S-3-chloropropan-1,2-diol, Author is Jones, Haydn F., which mentions a compound: 60827-45-4, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2, Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol.

S-ClCH2CH(OH)CH2OH (S-I) was prepared from Me 6-chloro-6-deoxy-α-D-glucopyranoside by sequential oxidative ring cleavage, reduction and hydrolysis. R-I was similarly prepared from Me 5-chloro-5-deoxy-α-L-arabinofuranoside, which was obtained from Me 2,3-di-O-benzoyl-5-O-(p-tolylsulfonyl)-α-L-arabinofuranoside by chlorination and then deesterification.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jiang, Chengjun; Hong, Huabin researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《A new practical synthesis of ethyl (R)-(-)-4-cyano-3-hydroxybutyrate from (S)-3-chloro-1,2-propanediol》 about this compound( cas:60827-45-4 ) in Letters in Organic Chemistry. Keywords: cyanohydroxybutyrate atorvastatin precursor asym synthesis. We’ll tell you more about this compound (cas:60827-45-4).

A practical chem. synthesis of (R)-4-cyano-3-hydroxybutyrate was accomplished starting from (S)-3-chloro-1,2-propanediol, which is the main byproduct originating from (S,S)-salen Co(III)-catalyzed hydrolytic kinetic resolution of epichlorohydrin. The new synthetic approach demonstrated an efficient utilization of organic byproduct for the asym. synthesis of the intermediate of atorvastatin.

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Iodide – Wikipedia,
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Safety of (2S)-(+)-3-Chloropropane-1,2-diol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Stereoselective crystallization of 3-(2,6-dimethylphenoxy)propane-1,2-diol: preparation of the single-enantiomer drug mexiletine.

Racemic 3-(2,6-dimethylphenoxy)propane-1,2-diol 8 undergoes spontaneous resolution upon crystallization This fact is confirmed by the m.p. inspection, vibration spectra and X-ray single crystal diffraction of racemic and scalemic crystalline samples of 8. Racemic 8 has been effectively resolved by a preferential crystallization procedure into (S)- and (R)-enantiomers with ee of approx. 90%. The enantiomeric purity of (S)- and (R)-8 could be increased to ee >99% through simple recrystallization Nonracemic diols 8 were converted into nonracemic 1,2-epoxy-3-(2,6-dimethylphenoxy)propanes (S)- and (R)-7 with ee 98% via Mitsunobu reaction. The reaction proceeded without loss of enantiomeric purity, and the initial configuration of the stereogenic center was conserved. Enantiopure epoxides 7 were converted into nonracemic 1-(2,6-dimethylphenoxy)propan-2-ols 2, which are valuable intermediates in single-enantiomer mexiletine synthesis.

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Iodide – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A formal synthesis of (+)-α-allokainic acid via sulfanyl radical addition-cyclization reaction, published in 1997-12-31, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol.

Sulfanyl radical addition-cyclization of diallylamine I in the presence of thiophenol and AIBN gave the 2,3,4-trisubstituted pyrrolidines II (R = PhSCH2, R1 = H; R = H, R1 = PhSCH2) which were effectively converted into the known key intermediate for the synthesis of (+)-α-allokainic acid via conversion of the phenylsulfanylmethyl group into the isopropenyl group at the 4-position.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Asymmetric hydrolysis of esters by biochemical methods. Part III. Asymmetric hydrolysis of (±)-1,2-diacetoxy-3-chloropropane and its related compounds with lipase. Synthesis of optically pure (S)-propranolol, published in 1982-05-31, which mentions a compound: 60827-45-4, mainly applied to diacetoxychloropropane asym hydrolysis lipase, Safety of (2S)-(+)-3-Chloropropane-1,2-diol.

Asym. hydrolysis of (±)-1,2-diacetoxy-3-chloropropane (I) using lipoprotein lipase gave (S)-I of 90% enantiomeric excess (e.e.). Reactions of (S)-I with phenols in an alk. condition yielded the corresponding (S)-3-aryloxy-1,2-propranediols. (S)-Propranolol was prepared from (S)-3-(1-naphthoxy)-1,2-propanediol. Hydrolysis of (±)-1,2-diacetoxy-3-bromopropane (II) and (±)-1,2-diacetoxyethylbenzene (III) with the lipase afforded (S)-II of 77% e.e. and (R)-III of 73% e.e., resp.

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SDS of cas: 60827-45-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Catalytic behavior of wool-osmium tetroxide complex for asymmetric dihydroxylation of olefins. Author is Miao, Ju-Hong; Yang, Ji-Huo; Chen, Li-Yi; Tu, Bu-Xin; Huang, Mei-Yu; Jiang, Ying-Yan.

A new chiral polymer-metal complex, wool-osmium tetroxide (wool-OsO4) complex was prepared by a very simple method. This complex was able to catalyze the asym. dihydroxylation of allylamine to (R)-(+)-3-amino-1,2-propanediol and allyl chloride to (S)-(+)-3-chloro-1,2-propanediol. The optical yields amounted to 83.7 and 57.2%, and the product yields were 80.2 and 68.5% resp. The exptl. results showed that OsO4 content in the complex, reaction time, allylamine/OsO4 molar ratio and solvent all have an effect on the product and optical yields. Addnl., wool-OsO4 complex catalyst could be reused without any remarkable change in optical catalytic activity.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Asymmetric synthesis of (S)-propranolol and (R)-propranolol.Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol.

The asym. synthesis of propranolol, a known β-blocker, was described. The target compounds thus prepared were (-)-(S)-propranolol [i.e., (2S)-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol] and its corresponding (+)-(R)-isomer [i.e., (2R)-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol]. Highly enantioenriched (S)-epichlorohydrin and (R)-3-chloro-1,2-propanediol were obtained from the kinetic hydrolysis resolution of racemic epichlorohydrin by using a chiral salen-CoIII complex. (S)-Epichlorohydrin was used as chiral reagent to synthesize (S)-propranolol and (R)-propranolol in yields of 80.9% and 74.5% with higher than 99% ee.

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