Category: 60827-45-4

Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Biosynthesis of (R)-epichlorohydrin at high substrate concentration by kinetic resolution of racemic epichlorohydrin with a recombinant epoxide hydrolase. Author is Jin, Huo-Xi; Liu, Zhi-Qiang; Hu, Zhong-Ce; Zheng, Yu-Guo.

The substrate concentration and yield were shown to be very low in the production of (R)-epichlorohydrin by hydrolysis of racemic epichlorohydrin using epoxide hydrolases in previous studies. In this work, we synthesized an epoxide hydrolase gene from Agrobacterium radiobacter and expressed it in Escherichia coli by the PCR assembly method. The recombinant A. radiobacter epoxide hydrolase (ArEH) was applied in the preparation of (R)-epichlorohydrin and, a yield of 42.7% with ≥99% enantiomeric excess (ee) from 25.6 mM racemic epichlorohydrin was obtained. However, the ee of (R)-epichlorohydrin was not able to reach 99% due to substrate and product inhibition when the substrate concentration was over 320 mM. Inhibition studies revealed that (S)-3-chloro-1,2-propanediol displayed non-competitive inhibition in the conversion of (S)-epichlorohydrin but non-significant inhibition for (R)-epichlorohydrin. Moreover, ArEH was successfully applied in the preparation of (R)-epichlorohydrin at high substrate concentration by eliminating the substrate inhibition. The substrate concentration increased to 448 mM by intermittent feeding of the substrate and to 512 mM by using a two-phase reaction system, with a high yield (>27%) and ee (>98%) of (R)-epichlorohydrin. This is the first report of high-yield production of (R)-epichlorohydrin at high substrate concentration, laying the foundations for its application on the industrial scale.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Optical isomers of chloropropanols: Mechanisms of their formation and decomposition in foods, published in 2002, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Recommanded Product: 60827-45-4.

Protein hydrolyzates produced by hydrochloric acid hydrolysis were analyzed for 3-chloropropane-1,2-diol and its enantiomers. It was found that (R)-3-chloropropane-1,2-diol and (S)-3-chloropropane-1,2-diol were present in the hydrolyzates in equimolar concentrations Model system experiments with glycerol, triolein and soy lecithin heated with hydrochloric acid in solution showed that these materials were precursors of 3-chloropropane-1,2-diol and yielded racemic mixtures of its enantiomers. Yields of 3-chloropropane-1,2-diols decreased in the order triolein > lecithin > glycerol. Mechanisms of 3-chloropropane-1,2-diol enantiomer formation during the production of protein hydrolyzates are presented and discussed as well as reaction pathways of their decomposition in alk. media via the corresponding (R)- and (S)-hydroxymethyloxiranes. In alk. media both 3-chloropropane-1,2-diol enantiomers decomposed at the same rate.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jones, A. R.; Porter, L. M. researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《Inhibition of glycolysis in boar spermatozoa by α-chlorohydrin phosphate appears to be mediated by phosphatase activity》 about this compound( cas:60827-45-4 ) in Reproduction, Fertility and Development. Keywords: pig sperm glycolysis chlorohydrin phosphate phosphatase. We’ll tell you more about this compound (cas:60827-45-4).

(R,S)-α-chlorohydrin-1-phosphate, previously shown to have no anti-glycolytic activity on mature boar sperm in vitro, is a substrate for acid and/or neutral phosphatase(s) that are associated with washed sperm. The high phosphatase activity hydrolyses the ester to α-chlorohydrin which undergoes oxidation to (S)-3-chlorolactaldehyde, a specific inhibitor of sperm glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase, thereby exhibiting an anti-glycolytic action.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.Formula: C3H7ClO2.Becker, Heinrich; Sharpless, K. Barry published the article 《A new ligand class for the asymmetric dihydroxylation of olefins》 about this compound( cas:60827-45-4 ) in Angewandte Chemie, International Edition in English. Keywords: asym dihydroxylation olefin anthraquinone ligand; dihydroquinidinylanthraquinone preparation ligand asym dihydroxlation. Let’s learn more about this compound (cas:60827-45-4).

1,4-Bis(dihydroquinidinyl)- and 1,4-bis(dihydroquininyl)anthraquinone are new ligands which show superior enantioselectivity in the asym. dihydroxylation of almost all olefins having only aliphatic substituents.

There is still a lot of research devoted to this compound(SMILES：OC[C@H](O)CCl)Formula: C3H7ClO2, and with the development of science, more effects of this compound(60827-45-4) can be discovered.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 60827-45-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Synthesis of polymeric salen complexes and application in the enantioselective hydrolytic kinetic resolution of epoxides as catalysts. Author is Kwon, Mi-Ae; Kim, Geon-Joong.

The polymeric (salen) Co(III) catalysts containing various counter anions have been synthesized, and the asym. catalytic activities of these newly synthesized polymer-type salen complexes were investigated in the HKR of terminal epoxides. The polymeric chiral salen Co(III) complexes catalyze the hydrolysis of epichlorohydrin, 1,2-epoxybutane, 1,2-epoxyhexane and epoxystyrene with very high enantioselectivities under mild conditions. The catalysts could be recovered and reused several times without further treatment after reaction, showing no loss of activity and enantioselectivity.

Compound(60827-45-4)Related Products of 60827-45-4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2S)-(+)-3-Chloropropane-1,2-diol), if you are interested, you can check out my other related articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Spontaneous resolution among chiral glycerol derivatives: crystallization features of ortho-alkoxysubstituted phenyl glycerol ethers, published in 2007-08-22, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Computed Properties of C3H7ClO2.

Five chiral arylglycerol ethers 2-R-C6H4-O-CH2CH(OH)CH2OH (R = OMe, OEt, OPrn, OPri, OBut) have been prepared in racemic and enantiopure form. The m.ps. and enthalpies of fusion of every species were measured by differential scanning calorimetry. Binary phase diagrams were reconstructed for the whole family, the entropies of the mixing of the enantiomers in the liquid state, and Gibbs free energy of formation of the racemic compound, as well as Pettersson i-values were derived from the thermal data. The differences in the phase behavior of the investigated compounds were associated with the conformations of the alkoxy fragments.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about New cations for ionic liquids, including chiral adjuncts with phosphate and sulfonylimide anions. Author is Engel, Robert; Lall-Ramnarine, Sharon; Coleman, Delroy; Thomas, Marie.

Symposium proceedings. A series of new ionic liquids has been prepared and investigated incorporating a variety of ammonium and polyammonium cationic components. These include several topogs., including linear arrays (strings) with stereogenic sites along the array, and both pyrrolidinium and pyridinium species bearing ether and chiral adjuncts. The associated anions for these systems include the (environmentally friendlier) phosphate and bis(trifluoromethyl)sulfonylimide species. Phys. and chem. characteristics of the anhydrous ionic liquids have been investigated.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol.Lok, C. M.; Ward, J. P.; Van Dorp, D. A. published the article 《The synthesis of chiral glycerides starting from D- and L-serine》 about this compound( cas:60827-45-4 ) in Actes Congr. Mond. – Soc. Int. Etude Corps Gras, 13th. Keywords: glyceride chiral synthesis serine. Let’s learn more about this compound (cas:60827-45-4).

Chiral glycerides were prepared starting from D- and L-serine by a multistep stereospecific sequence. E.g., L-serine was converted by diazotization and esterification into Me L-glycerate, this by acetalization and reduction to 2,3-O-isopropylidene-sn-glycerol, which was converted by sequential chlorination, hydrolysis, and cyclocondensation to D-glycidol (I). I could be acylated, then esterified with a fatty acid to give a diglyceride mixture, which could be isomerized by heating to 100% 1,3-diglycerides, or its hydroxyl group could be protected by a trityl group and it could be converted into a 1,2-diglyceride. Both types of diglycerides could be converted conventionally into sn-triglycerides.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Comparative Study, Article, Research Support, Non-U.S. Gov’t, Contraception called The action of (S)-α-chlorohydrin and 6-chloro-6-deoxyglucose on the metabolism of guinea pig spermatozoa, Author is Jones, A. R.; Ford, S. A., which mentions a compound: 60827-45-4, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2, Product Details of 60827-45-4.

(S)-α-Chlorohydrin  [60827-45-4] inhibited the conversion of D-fructose  [57-48-7] to lactate  [50-21-5] by mature guinea pig spermatozoa in vitro. At 2 mM, there was a specific inhibition of glyceraldehyde-phosphate dehydrogenase  [9001-50-7], resulting in the accumulation of fructose 1,6-bisphosphate  [488-69-7], dihydroxyacetone 3-phosphate  [57-04-5], and glyceraldehyde 3-phosphate  [591-59-3] and a concomitant decrease in the concentration of endogenous lactate. (R,S)-[3-36Cl]-α-chlorohydrin was metabolized by the spermatozoa to 3-chlorolactaldehyde  [84709-24-0] of unknown configuration. Exogenous (R,S)-3-chlorolactaldehyde  [84709-24-0] (2 mM) was an inhibitor of glyceraldehyde-phosphate dehydrogenase in guinea pig spermatozoa, whereas (R)-α-chlorohydrin  [57090-45-6] (10 mM) had no significant effect on the metabolism of fructose. 6-Chloro-6-deoxyglucose  [40656-44-8] (10 mM) inhibited glyceraldehyde-phosphate dehydrogenase in guinea pig spermatozoa in vitro and was metabolized to 3-chlorolactaldehyde which was presumably the (S)-isomer. The antiglycolytic actions of (S)-α-chlorohydrin and 6-chloro-6-deoxyglucose in guinea pig spermatozoa are probably due to the action of a common metabolite, (S)-3-chlorolactaldehyde  [86747-03-7].

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, Article, Research Support, Non-U.S. Gov’t, Reproduction, Fertility and Development called Inhibition of glycolysis in boar spermatozoa by α-chlorohydrin phosphate appears to be mediated by phosphatase activity, Author is Jones, A. R.; Porter, L. M., the main research direction is pig sperm glycolysis chlorohydrin phosphate phosphatase.Related Products of 60827-45-4.

(R,S)-α-chlorohydrin-1-phosphate, previously shown to have no anti-glycolytic activity on mature boar sperm in vitro, is a substrate for acid and/or neutral phosphatase(s) that are associated with washed sperm. The high phosphatase activity hydrolyses the ester to α-chlorohydrin which undergoes oxidation to (S)-3-chlorolactaldehyde, a specific inhibitor of sperm glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase, thereby exhibiting an anti-glycolytic action.

If you want to learn more about this compound((2S)-(+)-3-Chloropropane-1,2-diol)Related Products of 60827-45-4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(60827-45-4).

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com