Category: 60827-45-4

Formula: C3H7ClO2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Reaction kinetics of hydrolytic resolution of epichlorohydrin catalyzed by chiral salen metal complex. Author is Liu, Tao; Ruan, Wenjuan; Zhang, Yuling; Zhu, Zhi’ang; Chen, Rongti.

The reaction kinetics of hydrolytic resolution of racemic epichlorohydrin to chiral 3-chloro-1,2-propanediol and optically active epichlorohydrin, catalyzed by chiral salen metal complexes, was studied by using gas chromatog. The effects of temperature, catalyst type and catalyst concentration on the reaction rate were explored.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.Synthetic Route of C3H7ClO2.Bredikhina, Z. A.; Novikova, V. G.; Efremov, Yu. Ya.; Sharafutdinova, D. R.; Bredikhin, A. A. published the article 《4(2)-Methoxyphenyl glycerol ethers in the synthesis of non-racemic di-O,O-acylglycerols》 about this compound( cas:60827-45-4 ) in Russian Chemical Bulletin. Keywords: enantioselective hydrolysis epichlorohydrin catalyst glyceride synthesis resolution; methoxyphenyl glyceride ether synthesis glycerol chloropropanediol resolution aryloxypalmitoyl. Let’s learn more about this compound (cas:60827-45-4).

Effective methods for the synthesis of non-racemic 4- and 2-methoxyphenyl glycerol ethers from non-racemic 3-chloropropanediols and by direct resolution of the racemate, resp., were developed. Some existing discrepancies related to the to chiroptical properties of their derivatives were eliminated. Both ethers were used to synthesize non-racemic 3-O-aryloxy-1,2-di-O’,O”-palmitoyl glycerols.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.SDS of cas: 60827-45-4.Jones, Haydn F. published the article 《Stereospecific synthesis of R- and S-3-chloropropan-1,2-diol》 about this compound( cas:60827-45-4 ) in Chemistry & Industry (London, United Kingdom). Keywords: chloropropandiol stereospecific preparation; propanediol chloro stereospecific preparation; glycoside synthon chloropropanediol. Let’s learn more about this compound (cas:60827-45-4).

S-ClCH2CH(OH)CH2OH (S-I) was prepared from Me 6-chloro-6-deoxy-α-D-glucopyranoside by sequential oxidative ring cleavage, reduction and hydrolysis. R-I was similarly prepared from Me 5-chloro-5-deoxy-α-L-arabinofuranoside, which was obtained from Me 2,3-di-O-benzoyl-5-O-(p-tolylsulfonyl)-α-L-arabinofuranoside by chlorination and then deesterification.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Solid state properties and effective resolution procedure for guaifenesin, 3-(2-methoxyphenoxy)-1,2-propanediol, the main research direction is guaifenesin enantiomer resolution.HPLC of Formula: 60827-45-4.

Racemic expectorant guaifenesin, 3-(2-methoxyphenoxy)-1,2-propanediol (2) undergoes spontaneous resolution upon crystallization This fact is confirmed by thermal anal. (single eutectic V-shape binary melting phase diagram, adequate entropy and free energy characteristics). Racemic 2 could be effectively resolved into (S)- and (R)-2 by a preferential crystallization procedure. Single enantiomer drugs levomoprolol and levotensin were obtained by starting from enantiomeric 2 through the sulfite route.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (2S)-(+)-3-Chloropropane-1,2-diol(SMILESS: OC[C@H](O)CCl,cas:60827-45-4) is researched.Related Products of 591-54-8. The article 《Inhibition of fructolytic enzymes in boar spermatozoa by (S)-α-chlorohydrin and 1-chloro-3-hydroxypropanone》 in relation to this compound, is published in Australian Journal of Biological Sciences. Let’s take a look at the latest research on this compound (cas:60827-45-4).

When boar spermatozoa were incubated with (S)-α-chlorohydrin  [60827-45-4], glyceraldehyde-3-phosphate dehydrogenase (GPD) [9001-50-7] activity was inhibited. The (R)-isomer had no effect whereas (R,S)-3-chlorolactaldehyde  [84709-24-0] also inhibited GDP and lactate dehydrogenase  [9001-60-9]. The in vitro production of (S)-3-chlorolactaldehyde  [86747-03-7], the active metabolite of (S)-α-chlorohydrin, was attempted by incubating boar spermatozoa with 1-chloro-3-hydroxypropanone  [24423-98-1]. Preliminary results indicated that this compound is converted into (S)-3-chlorolactaldehyde as well as to another metabolite which is an inhibitor of other enzymes within the fructolytic pathway.

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Iodide – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.Name: (2S)-(+)-3-Chloropropane-1,2-diol.Ford, W. C. L.; Harrison, Anne; Waites, G. M. H. published the article 《Effects of the optical isomers of α-chlorohydrin on glycolysis by ram testicular spermatozoa and the fertility of male rats》 about this compound( cas:60827-45-4 ) in Journal of Reproduction and Fertility. Keywords: chlorohydrin sperm glycolysis fertility. Let’s learn more about this compound (cas:60827-45-4).

When 0.1 mM S-α-chlorohydrin [60827-45-4] was present in incubations, glycolysis by ram testicular spermatozoa was almost completely inhibited whereas 10 mM R-α-chlorohydrin [57090-45-6] had no effect. Male rats dosed orally with S-α-chlorohydrin (3.25 mg/kg/day) became much less fertile than controls but those dosed with R-α-chlorohydrin (13 mg/kg/day) did not. The loss of fertility was associated with a reduced ability of spermatozoa from the cauda epididymidis of these rats to oxidize glucose [50-99-7]. Apparently, the S enantiomer is responsible for both the inhibition of sperm glycolysis and the reduction in fertility caused by the racemic mixture of α-chlorohydrin.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Suzuki, Toshio; Kasai, Naoya; Minamiura, Noshi researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《Microbial production of optically active 1,2-diols using resting cells of Alcaligenes sp. DS-S-7G》 about this compound( cas:60827-45-4 ) in Journal of Fermentation and Bioengineering. Keywords: diol production Alcaligenes enantioselective oxidation. We’ll tell you more about this compound (cas:60827-45-4).

A novel generation method of optically active 1,2-diols with excellent optical purity (>98% enantiomeric excess) from their racemates was developed using the resting cells of Alcaligenes sp. DS-S-7G. This method was based on microbial enantioselective oxidation of the racemic 1,2-diols. When 1% 1,2-butanediol was used as a substrate, the degradation reaction in the presence of NAD+ could be carried out 8 times in 200 h.

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Iodide – Wikipedia,
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Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Ab initio and DFT calculations of three-body interactions in chiral mixtures. Author is Fujisawa, M.; Kimura, T..

In order to elucidate the enthalpic stabilization of a 2-methyl-1,4-butanediol system (2M14BD) and a 3-chloro-1,2-propanediol (3C12PDO) system by mixing of each (R)- and (S)-enantiomers, three-body interaction energies are obtained by PW91/6-311G** and MP2/6-311G** level calculations The differences between homochiral interactions and heterochiral interactions in a 3C12PDO system are found. On the other hand, in 2M14BD systems, very slight differences can be observed between the three-body interaction energies of the three ternary systems. Further, the relationship between excess enthalpies and chiral interactions is discussed.

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Becker, Heinrich; Sharpless, K. Barry published the article 《A new ligand class for the asymmetric dihydroxylation of olefins》. Keywords: asym dihydroxylation olefin anthraquinone ligand; dihydroquinidinylanthraquinone preparation ligand asym dihydroxlation.They researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:60827-45-4) here.

1,4-Bis(dihydroquinidinyl)- and 1,4-bis(dihydroquininyl)anthraquinone are new ligands which show superior enantioselectivity in the asym. dihydroxylation of almost all olefins having only aliphatic substituents.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Inhibitory effect of (s)-chlorohydrin on rat sperm motility and hyperactivation, published in 2012-09-30, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Synthetic Route of C3H7ClO2.

The effects of (S)-α-chlorohydrin (SACH) on rat epididymal sperm motility and hyperactivation and the mechanisms of the effects were studied. 20 Adult male Sprague-Dawley rats were divided randomly into 4 groups and dosed orally with 0, 2.5, 5.0, and 10mg/kg BW SACH for 52 days. After the cauda epididymal sperm were incubated under a capacitating condition for 5h, sperm motility and hyperactivation parameters were obtained by computer-assisted sperm anal. (CASA), and sperm-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) activity, ATP (ATP), and cyclic adenosine monophosphate (cAMP) were assayed. The protecting effect of pentoxifylline (PTF) against SACH was also tested. The sperm from the SACH-treated rats showed significant decreases in curvilinear velocity (VCL), average path velocity (VAP), straight line velocity (VSL), and amplitude of lateral head movement (ALH) (P<0.01 of all), and an increase in linearity (LIN) (P<0.01). The SACH-treated rats had much less sperm population with VCL≥400μm/s or LIN≤20% than that of the control (P<0.05 and P<0.01, resp.), indicating that SACH diminishes hyperactivation of rat sperm. GAPDS activities were inhibited by SACH, and decreasing trends of ATP and cAMP levels were observed PTF rescued the cAMP level which was depressed by SACH, and alleviated partly the inhibition of sperm motility and hyperactivation. SACH impairs the motility and hyperactivation of rat sperm, which might be related to inhibition of GAPDS by SACH and subsequent defects of ATP and cAMP. Compound(60827-45-4)Synthetic Route of C3H7ClO2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2S)-(+)-3-Chloropropane-1,2-diol), if you are interested, you can check out my other related articles.

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