Category: 60827-45-4

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The antiglycolytic action of (S)-α-chlorohydrin on epididymal bovine spermatozoa in vitro》. Authors are Jones, A. R.; Du Toit, J. I..The article about the compound:(2S)-(+)-3-Chloropropane-1,2-diolcas:60827-45-4,SMILESS:OC[C@H](O)CCl).Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol. Through the article, more information about this compound (cas:60827-45-4) is conveyed.

(S)-α-Chlorohydrin  [60827-45-4] interferes with glycolysis in bovine spermatozoa, whereas the (R)-isomer is ineffective. The action of the (S)-isomer, which involves inhibition of the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase  [9001-50-7], is not immediate but is evident only after a brief period of incubation with the spermatozoa. This inhibitory action is prevented when glycerol  [56-81-5] is present, suggesting that the mechanism of action of (S)-α-chlorohydrin requires its oxidation to (S)-3-chlorolactaldehyde  [86747-03-7], which is the active metabolite. Addition of (R,S)-3-chlorolactaldehyde  [84709-24-0] to bovine spermatozoa caused immediate inhibition of glycolysis. The action of (S)-α-chlorohydrin in bovine spermatozoa may be similar to that observed in the spermatozoa of other species in being a 2-stage process: 1st, its oxidation to (S)-3-chlorolactaldehyde, and then inhibition of the glycolytic enzyme by this metabolite.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Stevenson, D.; Jones, A. R. researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Synthetic Route of C3H7ClO2.They published the article 《Production of (S)-3-chlorolactaldehyde from (S)-α-chlorohydrin by boar spermatozoa and the inhibition of glyceraldehyde 3-phosphate dehydrogenase in vitro》 about this compound( cas:60827-45-4 ) in Journal of Reproduction and Fertility. Keywords: chlorolactaldehyde formation chlorohydrin sperm. We’ll tell you more about this compound (cas:60827-45-4).

The male antifertility agent (S)-α-chlorohydrin  [60827-45-4] was metabolized by mature boar spermatozoa in vitro to (S)-3-chlorolactaldehyde  [86747-03-7]. This oxidative process, which did not occur when (R)-α-chlorohydrin was offered as a substrate, was catalyzed by an NADP-dependent dehydrogenase that converts glycerol  [56-81-5] to glyceraldehyde. (S)-3-Chlorolactaldehyde, produced by this metabolic reaction or when added to suspensions of boar spermatozoa, was a specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase  [9028-92-6] as assessed by the accumulation of fructose 1,6-diphosphate and the triose phosphates. When glycerol and (S)-α-chlorohydrin were added concomitantly to boar spermatozoa in vitro, the presence of glycerol decreased the degree of inhibition of glyceraldehyde 3-phosphate dehydrogenase. Extracts of glyceraldehyde 3-phosphate dehydrogenase that were obtained from boar spermatozoa incubated with (S)-α-chlorohydrin or (R,S)-3-chlorolactaldehyde  [84709-24-0] showed significant reductions in their enzymic activity.

Compound(60827-45-4)Synthetic Route of C3H7ClO2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2S)-(+)-3-Chloropropane-1,2-diol), if you are interested, you can check out my other related articles.

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Iodide – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Catalytic behavior of wool-osmium tetroxide complex for asymmetric dihydroxylation of olefins, published in 2004-04-30, which mentions a compound: 60827-45-4, mainly applied to asym dihydroxylation allylamine allyl chloride wool supported osmium tetroxide, Safety of (2S)-(+)-3-Chloropropane-1,2-diol.

A new chiral polymer-metal complex, wool-osmium tetroxide (wool-OsO4) complex was prepared by a very simple method. This complex was able to catalyze the asym. dihydroxylation of allylamine to (R)-(+)-3-amino-1,2-propanediol and allyl chloride to (S)-(+)-3-chloro-1,2-propanediol. The optical yields amounted to 83.7 and 57.2%, and the product yields were 80.2 and 68.5% resp. The exptl. results showed that OsO4 content in the complex, reaction time, allylamine/OsO4 molar ratio and solvent all have an effect on the product and optical yields. Addnl., wool-OsO4 complex catalyst could be reused without any remarkable change in optical catalytic activity.

Compound(60827-45-4)Safety of (2S)-(+)-3-Chloropropane-1,2-diol received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2S)-(+)-3-Chloropropane-1,2-diol), if you are interested, you can check out my other related articles.

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Iodide – Wikipedia,
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HPLC of Formula: 60827-45-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Study on synthesis and properties of chloride-[1-ethyl-3-(1,2-dihydroxypropyl)]imidazole ionic liquid. Author is Li, Yongmin; Yang, Jianguo; Lin, Caiping.

A method for the synthesis of the title compound is reported here. A chiral imidazole ionic liquid was prepared from 1-ethylimidazole and (2S)-3-chloro-1,2-propanediol. The resulting chiral ionic liquid was characterized by NMR. Its elec. conductivity in different solvents was determined The result shows that the ionic liquid can be dissolved in acetonitrile, acetone, ethanol, water, N, N-dimethylformamide (DMF) but not in Et acetate. The elec. conductivity of the ionic liquid is also measured at different temperatures and concentrations, and the result shows that the elec. conductivity value increases along with concentration and temperature, and the value of elec. conductivity K is different in different solvents. Its order is as follow: K(acetonitrile)=K(water)>K(DMF)>K(acetone)>K.

Compound(60827-45-4)HPLC of Formula: 60827-45-4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2S)-(+)-3-Chloropropane-1,2-diol), if you are interested, you can check out my other related articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 60827-45-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Production of (S)-3-chlorolactaldehyde from (S)-α-chlorohydrin by boar spermatozoa and the inhibition of glyceraldehyde 3-phosphate dehydrogenase in vitro. Author is Stevenson, D.; Jones, A. R..

The male antifertility agent (S)-α-chlorohydrin  [60827-45-4] was metabolized by mature boar spermatozoa in vitro to (S)-3-chlorolactaldehyde  [86747-03-7]. This oxidative process, which did not occur when (R)-α-chlorohydrin was offered as a substrate, was catalyzed by an NADP-dependent dehydrogenase that converts glycerol  [56-81-5] to glyceraldehyde. (S)-3-Chlorolactaldehyde, produced by this metabolic reaction or when added to suspensions of boar spermatozoa, was a specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase  [9028-92-6] as assessed by the accumulation of fructose 1,6-diphosphate and the triose phosphates. When glycerol and (S)-α-chlorohydrin were added concomitantly to boar spermatozoa in vitro, the presence of glycerol decreased the degree of inhibition of glyceraldehyde 3-phosphate dehydrogenase. Extracts of glyceraldehyde 3-phosphate dehydrogenase that were obtained from boar spermatozoa incubated with (S)-α-chlorohydrin or (R,S)-3-chlorolactaldehyde  [84709-24-0] showed significant reductions in their enzymic activity.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Hao; Zheng, Weiwei; Wang, Xia; Liu, Li; Qu, Weidong researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Safety of (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《Inhibitory effect of (s)-chlorohydrin on rat sperm motility and hyperactivation》 about this compound( cas:60827-45-4 ) in Weisheng Yanjiu. Keywords: chlorohydrin sperm motility hyperactivation. We’ll tell you more about this compound (cas:60827-45-4).

The effects of (S)-α-chlorohydrin (SACH) on rat epididymal sperm motility and hyperactivation and the mechanisms of the effects were studied. 20 Adult male Sprague-Dawley rats were divided randomly into 4 groups and dosed orally with 0, 2.5, 5.0, and 10mg/kg BW SACH for 52 days. After the cauda epididymal sperm were incubated under a capacitating condition for 5h, sperm motility and hyperactivation parameters were obtained by computer-assisted sperm anal. (CASA), and sperm-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) activity, ATP (ATP), and cyclic adenosine monophosphate (cAMP) were assayed. The protecting effect of pentoxifylline (PTF) against SACH was also tested. The sperm from the SACH-treated rats showed significant decreases in curvilinear velocity (VCL), average path velocity (VAP), straight line velocity (VSL), and amplitude of lateral head movement (ALH) (P<0.01 of all), and an increase in linearity (LIN) (P<0.01). The SACH-treated rats had much less sperm population with VCL≥400μm/s or LIN≤20% than that of the control (P<0.05 and P<0.01, resp.), indicating that SACH diminishes hyperactivation of rat sperm. GAPDS activities were inhibited by SACH, and decreasing trends of ATP and cAMP levels were observed PTF rescued the cAMP level which was depressed by SACH, and alleviated partly the inhibition of sperm motility and hyperactivation. SACH impairs the motility and hyperactivation of rat sperm, which might be related to inhibition of GAPDS by SACH and subsequent defects of ATP and cAMP. Compound(60827-45-4)Safety of (2S)-(+)-3-Chloropropane-1,2-diol received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2S)-(+)-3-Chloropropane-1,2-diol), if you are interested, you can check out my other related articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bel-Rhlid, Rachid; Talmon, Jean P.; Fay, Laurent B.; Juillerat, Marcel A. published the article 《Biodegradation of 3-Chloro-1,2-propanediol with Saccharomyces cerevisiae》. Keywords: chloropropanediol biodegradation Saccharomyces cerevisiae.They researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Formula: C3H7ClO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:60827-45-4) here.

A novel enzymic dehalogenating activity of 3-chloro-1,2-propanediol (3-MCPD) with Saccharomyces cerevisiae (baker’s yeast) is reported. All bioconversion assays were carried out under aerobic conditions at 28°, and the kinetics were monitored. The biodegradation was performed at different pH values (6.2, 7.0, and 8.2), in the presence and absence of glucose, using racemic 3-MCPD at two different concentrations (7.3 μmol/L and 27 mmol/L). Optimal conversion (68%) of racemic (R,S)-3-MCPD at a concentration of 27 mmol/L was achieved after 48 h of reaction time, at pH 8.2, and in the presence of glucose. At a concentration of 7.3 μmol/L, 73% degradation was observed after 72 h, at pH 8.2 and in the absence of glucose. Under the same exptl. conditions, the conversion of pure (S)-3-MCPD (85%) was higher than that of the (R)-enantiomer (60%).

Compound(60827-45-4)Formula: C3H7ClO2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2S)-(+)-3-Chloropropane-1,2-diol), if you are interested, you can check out my other related articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 60827-45-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Biosynthesis of (R)-epichlorohydrin at high substrate concentration by kinetic resolution of racemic epichlorohydrin with a recombinant epoxide hydrolase. Author is Jin, Huo-Xi; Liu, Zhi-Qiang; Hu, Zhong-Ce; Zheng, Yu-Guo.

The substrate concentration and yield were shown to be very low in the production of (R)-epichlorohydrin by hydrolysis of racemic epichlorohydrin using epoxide hydrolases in previous studies. In this work, we synthesized an epoxide hydrolase gene from Agrobacterium radiobacter and expressed it in Escherichia coli by the PCR assembly method. The recombinant A. radiobacter epoxide hydrolase (ArEH) was applied in the preparation of (R)-epichlorohydrin and, a yield of 42.7% with ≥99% enantiomeric excess (ee) from 25.6 mM racemic epichlorohydrin was obtained. However, the ee of (R)-epichlorohydrin was not able to reach 99% due to substrate and product inhibition when the substrate concentration was over 320 mM. Inhibition studies revealed that (S)-3-chloro-1,2-propanediol displayed non-competitive inhibition in the conversion of (S)-epichlorohydrin but non-significant inhibition for (R)-epichlorohydrin. Moreover, ArEH was successfully applied in the preparation of (R)-epichlorohydrin at high substrate concentration by eliminating the substrate inhibition. The substrate concentration increased to 448 mM by intermittent feeding of the substrate and to 512 mM by using a two-phase reaction system, with a high yield (>27%) and ee (>98%) of (R)-epichlorohydrin. This is the first report of high-yield production of (R)-epichlorohydrin at high substrate concentration, laying the foundations for its application on the industrial scale.

Compound(60827-45-4)SDS of cas: 60827-45-4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2S)-(+)-3-Chloropropane-1,2-diol), if you are interested, you can check out my other related articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 60827-45-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about p-Tolyl glycerol ether: is it possible to find more simple molecular organogelator with pronounced chirality driven properties?. Author is Bredikhin, Alexander A.; Bredikhina, Zemfira A.; Akhatova, Flyura S.; Gubaidullin, Aidar T..

P-Tolyl glycerol ether not belonging to any of the known gelator families forms stable transparent gels in hydrocarbon media showing very good quant. characteristics of gelling abilities, which are, in turn, strongly dependent on the chiral characteristics of the gelator. The crystal packing differences between the rac- and scal-substances could be the reason for such behavior.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Three different types of chirality-driven crystallization within the series of uniformly substituted phenyl glycerol ethers, published in 2008-11-30, which mentions a compound: 60827-45-4, mainly applied to chirality driven crystallization uniformly phenyl glycerol ether crystallog, HPLC of Formula: 60827-45-4.

Seven chiral aryl glycerol ethers 2-R-C6H4-O-CH2CH(OH)CH2OH (R = H, Me, Et, Allyl, n-Pr, i-Pr, tert-Bu) were synthesized in racemic and scalemic form. The IR spectra, m.ps., and enthalpies of fusion for racemic and scalemic samples of every species were measured, the entropies of enantiomers mixing in the liquid state and Gibbs free energies of a racemic compound formation were derived and binary phase diagrams were reconstructed for the whole family. Solid racemic compounds stabilities were ranked for the four substances. Spontaneous resolution was established for the registered chiral drug mephenesin and its Et analog. Metastable anomalous conglomerate, forming crystals having three independent R* and one independent S* mols. in the unit cell, is formed during solution crystallization of tert-Bu derivative; metastable phase transforms slowly into traditional racemic conglomerate.

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Iodide – Wikipedia,
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