60827-45-4 Archives - Page 8 of 22 - Iodides-buliding-blocks

Analyzing the synthesis route of 60827-45-4

There are many compounds similar to this compound(60827-45-4)Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol.Suzuki, Toshio; Kasai, Naoya; Minamiura, Noshi published the article 《Microbial production of optically active 1,2-diols using resting cells of Alcaligenes sp. DS-S-7G》 about this compound( cas:60827-45-4 ) in Journal of Fermentation and Bioengineering. Keywords: diol production Alcaligenes enantioselective oxidation. Let’s learn more about this compound (cas:60827-45-4).

A novel generation method of optically active 1,2-diols with excellent optical purity (>98% enantiomeric excess) from their racemates was developed using the resting cells of Alcaligenes sp. DS-S-7G. This method was based on microbial enantioselective oxidation of the racemic 1,2-diols. When 1% 1,2-butanediol was used as a substrate, the degradation reaction in the presence of NAD+ could be carried out 8 times in 200 h.

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Flexible application of in synthetic route 60827-45-4

There are many compounds similar to this compound(60827-45-4)Formula: C3H7ClO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 60827-45-4, is researched, Molecular C3H7ClO2, about Production of chiral C3 units based on microbial resolution and their synthetic applications, the main research direction is chiral chloropropanol manufacture microorganism review; chloropropanediol resolution biochem review; epichlorohydrin glycidol asym synthesis review.Formula: C3H7ClO2.

A review with 52 references on production of optically pure glycerol derivatives, i.e., (R)- and (S)-2,3-dichloro-1-propanols and (R)- and (S)-3-chloro-1,2-propanediols, based on microbial resolution, and their conversion to optically active epichlorohydrin and glycidol, resp. Several synthetic applications are also described.

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The Absolute Best Science Experiment for 60827-45-4

In addition to the literature in the link below, there is a lot of literature about this compound((2S)-(+)-3-Chloropropane-1,2-diol)HPLC of Formula: 60827-45-4, illustrating the importance and wide applicability of this compound(60827-45-4).

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, Huaxue Yanjiu Yu Yingyong called Study on synthesis and properties of chloride-[1-ethyl-3-(1,2-dihydroxypropyl)]imidazole ionic liquid, Author is Li, Yongmin; Yang, Jianguo; Lin, Caiping, the main research direction is ionic liquid elec conductivity synthesize property.HPLC of Formula: 60827-45-4.

A method for the synthesis of the title compound is reported here. A chiral imidazole ionic liquid was prepared from 1-ethylimidazole and (2S)-3-chloro-1,2-propanediol. The resulting chiral ionic liquid was characterized by NMR. Its elec. conductivity in different solvents was determined The result shows that the ionic liquid can be dissolved in acetonitrile, acetone, ethanol, water, N, N-dimethylformamide (DMF) but not in Et acetate. The elec. conductivity of the ionic liquid is also measured at different temperatures and concentrations, and the result shows that the elec. conductivity value increases along with concentration and temperature, and the value of elec. conductivity K is different in different solvents. Its order is as follow: K(acetonitrile)=K(water)>K(DMF)>K(acetone)>K.

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An update on the compound challenge: 60827-45-4

There are many compounds similar to this compound(60827-45-4)Reference of (2S)-(+)-3-Chloropropane-1,2-diol. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference of (2S)-(+)-3-Chloropropane-1,2-diol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation. Author is Skamarauskas, J.; Carter, W.; Fowler, M.; Madjd, A.; Lister, T.; Mavroudis, G.; Ray, D. E..

The biochem. mechanism of toxicity of the exptl. astrocyte neurotoxicant and food contaminant S-3-chloro-1,2-propanediol (3-CPD) has been proposed to be via inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). We have confirmed this action in liver, which shows inhibition to 6.0±0.7% control at the neuropathic dose of 140 mg/kg. However, GAPDH activity in brain only fell to a min. of 54±24% control, and the concentrations of lactate and pyruvate (the downstream products of GAPDH), showed no pre-neuropathic decreases in 3-CPD susceptible brain tissue. There was no inhibition of GAPDH activity in primary astrocyte cultures at sub-cytotoxic exposures. We therefore sought alternative mechanisms to explain its toxicity to astrocytes. We were able to show that 3-CPD is a substrate for glutathione-S-transferase and also that, after bioactivation by alc. dehydrogenase, it generates an irreversible inhibitor of glutathione reductase. In addition, incubation of brain slices from the 3-CPD-vulnerable inferior colliculus produces a depletion of glutathione and an inhibition of glutathione-S-transferase that is not seen in equivalent slices taken from the 3-CPD-resistant occipital neocortex. A smaller but significant and similarly regionally selective decrease in glutathione content is also seen in vivo. We conclude that 3-CPD does not produce its astrocytic toxicity via energy deprivation, and suggest that selective bioactivation and consequent disruption of redox state is a more likely mechanism.

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Little discovery in the laboratory: a new route for 60827-45-4

Formula: C3H7ClO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Formation of the active antifertility metabolite of (S)-α-chlorohydrin in boar sperm. Author is Jones, A. R.; Stevenson, D..

Incubation of boar sperm with (S)-α-chlorohydrin (I) [60827-45-4] resulted in formation of (S)-3-chlorolactaldehyde (II) [86747-03-7]. I inhibited the production of 14CO2 when 14C-labeled fructose [57-48-7] was the substrate but had no effect when 14C-labeled glycerol [56-81-5] was used. (R,S)-3-Chlorolactaldehyde [84709-24-0], however, inhibited CO2 formation from glycerol. The oxidation of 14C-labeled glycerol-3-phosphate [57-03-4] was similarly inhibited by I confirming that the presence of glycerol but not its metabolites prevented the oxidation of I to II. Glycerol reversed the inhibition of fructose metab by I. Addnl., preincubation of sperm with I inhibited glycerol metabolism Apparently, I is metabolized to II in sperm by an enzyme involved in the oxidation of glycerol to glyceraldehyde. The presence of glycerol decreases the activity of this enzyme towards I thereby preventing formation of II, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase [9001-50-7].

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Extended knowledge of 60827-45-4

Reference of (2S)-(+)-3-Chloropropane-1,2-diol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Biodegradation of 3-Chloro-1,2-propanediol with Saccharomyces cerevisiae. Author is Bel-Rhlid, Rachid; Talmon, Jean P.; Fay, Laurent B.; Juillerat, Marcel A..

A novel enzymic dehalogenating activity of 3-chloro-1,2-propanediol (3-MCPD) with Saccharomyces cerevisiae (baker’s yeast) is reported. All bioconversion assays were carried out under aerobic conditions at 28°, and the kinetics were monitored. The biodegradation was performed at different pH values (6.2, 7.0, and 8.2), in the presence and absence of glucose, using racemic 3-MCPD at two different concentrations (7.3 μmol/L and 27 mmol/L). Optimal conversion (68%) of racemic (R,S)-3-MCPD at a concentration of 27 mmol/L was achieved after 48 h of reaction time, at pH 8.2, and in the presence of glucose. At a concentration of 7.3 μmol/L, 73% degradation was observed after 72 h, at pH 8.2 and in the absence of glucose. Under the same exptl. conditions, the conversion of pure (S)-3-MCPD (85%) was higher than that of the (R)-enantiomer (60%).

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New learning discoveries about 60827-45-4

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nakamura, Tetsuji; Yu, Fujio; Mizunashi, Wataru; Watanabe, Ichiro researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《Microbial transformation of prochiral 1,3-dichloro-2-propanol into optically active 3-chloro-1,2-propanediol》 about this compound( cas:60827-45-4 ) in Agricultural and Biological Chemistry. Keywords: prochiral dichloropropanol transformation chloropropanediol bacteria. We’ll tell you more about this compound (cas:60827-45-4).

Nine strains of bacteria isolated from soil were able convert 1,3-dichloro-2-propanol (DCP) to optically active 3-chloro-1,2-propanediol (MCP). The reaction was almost stoichiometric and the optical purity was ∼67-75% e.e. for (R)-isomer of MCP. Only one strain produced (S)-isomer of MCP with 38.8% e.e.

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Research on new synthetic routes about 60827-45-4

There are many compounds similar to this compound(60827-45-4)Category: iodides-buliding-blocks. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, Green Chemistry called Potential impacts of deep-sea injection of CO2 on marine organic chemistry, Author is Hu, Ji; Malic, Nino; Scott, Janet L.; Strauss, Christopher R., the main research direction is deep sea injection carbon dioxide effect marine organic chem; carbon dioxide epoxide effect marine organic chem seawater injection.Category: iodides-buliding-blocks.

The extent of reaction of epoxides in salt water changed markedly following introduction of gaseous or liquid CO2. Higher concentrations of β-chlorohydrins in carbonated salt water vs. concentrations in salt water alone were attributed to greater acidity of the aqueous phase. This suggested regimes for sequestering CO2 by deep sea injection should account for potential effects on marine organic chem. No evidence was obtained for enhanced nucleophilicity of Cl- through potential desolvation at the CO2-water interface.

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Simple exploration of 60827-45-4

There are many compounds similar to this compound(60827-45-4)Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Thermal Analysis and Calorimetry called Ab initio and DFT calculations of three-body interactions in chiral mixtures, Author is Fujisawa, M.; Kimura, T., which mentions a compound: 60827-45-4, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2, Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol.

In order to elucidate the enthalpic stabilization of a 2-methyl-1,4-butanediol system (2M14BD) and a 3-chloro-1,2-propanediol (3C12PDO) system by mixing of each (R)- and (S)-enantiomers, three-body interaction energies are obtained by PW91/6-311G** and MP2/6-311G** level calculations The differences between homochiral interactions and heterochiral interactions in a 3C12PDO system are found. On the other hand, in 2M14BD systems, very slight differences can be observed between the three-body interaction energies of the three ternary systems. Further, the relationship between excess enthalpies and chiral interactions is discussed.

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The Best Chemistry compound: 60827-45-4

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Asymmetric synthesis of (S)-Metoprolol, published in 2010-11-10, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Category: iodides-buliding-blocks.

Enantioenriched (S)-3-chloro-1,2-propanediol and (R)-epichlorohydrin were obtained by a kinetic hydrolysis resolution of racemic epichlorohydrin using (S,S)-salen-cobalt acetate and the synthesis of the target compound [i.e., 99% optically pure (S)-Metoprolol] was achieved by a reaction of 4-(2-methoxyethyl)phenol with (2S)-3-chloro-1,2-propanediol and a subsequent amination with 2-propanamine. When (R)-epichlorohydrin was used as a chiral precursor, (S)-Metoprolol was also formed but less optically pure (>92%). The overall product yield 53.9% and the product thus [(-)-Metoprolol, (2S)-1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol] was confirmed by IR, 1H-NMR, 13C-NMR, MS. This method may be suitable for industrial process adaptation.

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