Iodides-buliding-blocks

Palladium-catalyzed Methylsulfonylation of Alkyl Halides Using Dimethyl Sulfite as SO₂ Surrogate and Methyl Source was written by Xin, Yan-Hua;Guo, Ying-Qiong;Zhang, Xing-Guo;Deng, Chen-Liang. And the article was included in Journal of Organic Chemistry in 2021.Safety of 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

A novel and efficient method for the synthesis of Me sulfone derivatives RSO₂Me [R = Ph, 4-MeC₆H₄, 2-thienyl, etc.] via palladium-catalyzed methylsulfonylation of aryl and alkyl iodides with di-Me sulfite was described. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Safety of 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mixed-Ligand Chiral Rhodium(II) Catalyst Enables the Enantioselective Total Synthesis of Piperarborenine B was written by Panish, Robert A.;Chintala, Srinivasa R.;Fox, Joseph M.. And the article was included in Angewandte Chemie, International Edition in 2016.Application of 5460-32-2 This article mentions the following:

A novel, mixed-ligand chiral rhodium(II) catalyst, Rh₂(S-NTTL)₃(dCPA) (I), has enabled the first enantioselective total synthesis of the natural product piperarborenine B (II). A crystal structure of Rh₂(S-NTTL)₃(dCPA) reveals a “chiral crown” conformation with a bulky dicyclohexylphenyl acetate ligand and three N-naphthalimido groups oriented on the same face of the catalyst. The natural product was prepared on large scale using rhodium-catalyzed bicyclobutanation/copper-catalyzed homoconjugate addition chem. in the key step. The route proceeds in ten steps with an 8 % overall yield and 92 % ee. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Application of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electrophile-Mediated Reactions of Functionalized Propargylic Substrates was written by Urbanaite, Aurelija;Jonusis, Mantas;Buksnaitiene, Rita;Balkaitis, Simonas;Cikotiene, Inga. And the article was included in European Journal of Organic Chemistry in 2015.Formula: C8H9IO2 This article mentions the following:

Metal-free halogen, chalcogen, or (oxo)carbenium ion mediated yne-carbonyl or yne-thioxo transformations of a range of N- and O-propargylic compounds have been studied. This investigation has led to the development of a mild, economic, and effective method for the synthesis of functionalized 4H-1,3-oxazines, 4H-1,3-thiazines, 4,5-dihydrothiazoles, and α-substituted enones. The structure of the propargylic substrate and the nature of electrophile influence both the outcome and regioselectivity of processes. The synthesis of the target compounds was achieved using propargyl compounds as starting materials, such as N-[3-(4-methoxyphenyl)-2-propynyl]benzamide (alkyne-amide), N-[3-(4-methoxyphenyl)-2-propynyl]carbamic acid dimethylethyl ester (alkyne-carbamate), N-[3-(4-methoxyphenyl)-2-propynyl]-N‘-(phenylmethyl)urea (alkyne-urea). In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and properties of rhomboidal macrocyclic subunits of graphdiyne-like nanoribbons was written by Desroches, Maude;Courtemanche, Marc-Andre;Rioux, Genevieve;Morin, Jean-Francois. And the article was included in Journal of Organic Chemistry in 2015.Application In Synthesis of 4-Bromo-2-iodophenol This article mentions the following:

Rhomboidal macrocyclic subunits of graphdiyne-like nanoribbon (GDNR) bearing both alkyne and diyne units, allowing for multichannel π-conjugation, were synthesized using an oxidative Glaser-type ring closing reaction. These subunits, called the “meshes” of the nanoribbon, possess Ph groups with decyloxy solubilizing chains on each corner. The yields of the ring closing reaction highly depend on the metal (Cu or Pd) catalyst used for the macrocyclization step. Increasing the width of the meshes from one macrocycle to two fused macrocycles resulted in a decrease of the bandgap by 0.23 eV as shown by optical spectroscopy. The optimized geometries of the meshes alongside their HOMO and LUMO orbitals were calculated using DFT calculations at the B3LYP/6-31+G** level of theory. The results showed a nearly planar conformation for both meshes with HOMO and LUMO orbitals entirely delocalized over the mols. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application In Synthesis of 4-Bromo-2-iodophenol).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application In Synthesis of 4-Bromo-2-iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Approaches to the synthesis of 5-benzylidene-2-imidazolin-4-ones was written by Prager, Rolf H.;Tsopelas, Chris. And the article was included in Australian Journal of Chemistry in 1990.Product Details of 15813-09-9 This article mentions the following:

Aromatic aldehydes, but not ketones, condensed with glycocyamidine to give the benzylideneamines. α-Alkylbenzylideneglycocyamidines were made from glycidic esters by reaction with guanidine, followed by cyclization with Ac₂O. A number of mono- and diacetylated derivatives of 6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione have been prepared, but failed to undergo the Darzens reaction. Bromo- and iodo-2-arylazoimidazoles, protected on N by the methoxyethoxymethyl group, failed to undergo clean lithiation. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Product Details of 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Product Details of 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Solid-phase synthesis of amine/carboxyl substituted prolines and proline homologs: scope and limitations was written by Zhou, Ziniu;Scott, William L.;O’Donnell, Martin J.. And the article was included in Molecules in 2016.Synthetic Route of C4H8ClI This article mentions the following:

A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites. The procedure expands the diversity of substituted peptidomimetic mols. available to the Distributed Drug Discovery (D3) project. Using a BAL-based solid-phase synthetic sequence the proline or proline homolog subunit is both constructed and incorporated into the peptidomimetic by an α-alkylation, hydrolysis and intramol. cyclization sequence. Further transformations on solid-phase provide access to a variety of piperazine derivatives representing a class of mols. known to exhibit central nervous system activity. The procedure works well with proline cores, but with larger six- and seven-membered ring homologues the nature of the carboxylic acid acylating the cyclic amine can lead to side reactions and result in poor overall yields. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Synthetic Route of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Synthetic Route of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synergistic and Selective Copper/ppm Pd-Catalyzed Suzuki-Miyaura Couplings: In Water, Mild Conditions, with Recycling was written by Handa, Sachin;Smith, Justin D.;Hageman, Matthew S.;Gonzalez, Monica;Lipshutz, Bruce H.. And the article was included in ACS Catalysis in 2016.Category: iodides-buliding-blocks This article mentions the following:

Copper-catalyzed Suzuki-Miyaura couplings can be carried out exclusively on aryl iodides under very mild conditions, which is made possible by synergistic effects due to the presence of ppm levels of palladium as cocatalyst. The coupling requires a hemilabile P(O)-N ligand, together with the benefits of micellar catalysis using water as the recyclable reaction medium. In the experiment, the researchers used many compounds, for example, 2,2-Difluoro-4-iodobenzo[d][1,3]dioxole (cas: 531508-54-0Category: iodides-buliding-blocks).

2,2-Difluoro-4-iodobenzo[d][1,3]dioxole (cas: 531508-54-0) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-ones from 2-(o-haloaryloxy)acyl chlorides and primary amines was written by Hu, Qunxian;Xia, Ziming;Fan, Ling;Zheng, Jiening;Wang, Xiaoxia;Lv, Xin. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2012.Synthetic Route of C6H4BrIO This article mentions the following:

A facile and efficient Cu(I)-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3(4H)-one derivatives has been developed. The condensation between 2-(o-haloaryloxy)acyl chlorides and primary amines followed by Cu(I)-catalyzed intramol. C-N bond coupling afforded a variety of 2H-1,4-benzoxazin-3-(4H)-ones in good to excellent yields. Diversified substituents on the 4-position could be conveniently introduced. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Synthetic Route of C6H4BrIO).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Synthetic Route of C6H4BrIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach was written by Lin, Tsu-Kung;Hughes, Gillian;Muratovska, Aleksandra;Blaikie, Frances H.;Brookes, Paul S.;Darley-Usmar, Victor;Smith, Robin A. J.;Murphy, Michael P.. And the article was included in Journal of Biological Chemistry in 2002.Category: iodides-buliding-blocks This article mentions the following:

Mitochondria play a central role in redox-linked processes in the cell through mechanisms that are thought to involve modification of specific protein thiols, but this has proved difficult to assess. In particular, specific labeling and quantitation of mitochondrial protein cysteine residues have not been achieved due to the lack of reagents available that can be applied to the intact organelle or cell. To overcome these problems we have used a combination of mitochondrial proteomics and targeted labeling of mitochondrial thiols using a novel compound, (4-iodobutyl)triphenylphosphonium (IBTP). This lipophilic cation is accumulated by mitochondria and yields stable thioether adducts in a thiol-specific reaction. The selective uptake into mitochondria, due to the large membrane potential across the inner membrane, and the high pH of the matrix results in specific labeling of mitochondrial protein thiols by IBTP. Individual mitochondrial proteins that changed thiol redox state following oxidative stress could then be identified by their decreased reaction with IBTP and isolated by two-dimensional electrophoresis. We demonstrate the selectivity of IBTP labeling and use it to show that glutathione oxidation and exposure to an S-nitrosothiol or to peroxynitrite cause extensive redox changes to mitochondrial thiol proteins. In conjunction with blue native gel electrophoresis, we used IBTP labeling to demonstrate that thiols are exposed on the matrix faces of respiratory Complexes I, II, and IV. This novel approach enables measurement of the thiol redox state of individual mitochondrial proteins during oxidative stress and cell death. In addition the methodol. has the potential to identify novel redox-dependent modulation of mitochondrial proteins. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Category: iodides-buliding-blocks).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simultaneous reduction of aldehyde group to hydroxymethyl group in palladium-catalyzed Suzuki cross-coupling reaction was written by Wang, Yingchun;Li, Xiuying;Li, Yajun;Pan, Yingming;Cheng, Keguang;Wang, Hengshan. And the article was included in Chemical Research in Chinese Universities in 2014.Formula: C8H7IO2 This article mentions the following:

An efficient method for the palladium-catalyzed Suzuki cross-coupling reaction with the simultaneous reduction of the aldehyde to a hydroxymethyl group is described. In this method, halide substituted aryl aldehydes react with arylboronic acids to give polycyclic aromatic alcs. in moderate to good yields. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com