Iodides-buliding-blocks

Regioirregular and catalytic Mizoroki-Heck reactions was written by Garnes-Portoles, Francisco;Greco, Rossella;Oliver-Meseguer, Judit;Castellanos-Soriano, Jorge;Consuelo Jimenez, M.;Lopez-Haro, Miguel;Hernandez-Garrido, Juan Carlos;Boronat, Mercedes;Perez-Ruiz, Raul;Leyva-Perez, Antonio. And the article was included in Nature Catalysis in 2021.Computed Properties of C7H6FIO This article mentions the following:

Here, the ligand-free, few-atom palladium clusters in solution catalyze the α-selective intramol. Mizoroki-Heck coupling of iodoaryl cinnamates, and mechanistic studies support the formation of a sterically encumbered cinnamate-palladium cluster intermediate was showed. Following this rationale, the α-selective intermol. coupling of aryl iodides with styrenes was also achieved with palladium clusters encapsulated within fine-tuned and sterically restricted zeolite cavities to produce 1,1-bisarylethylenes, which are further engaged with aryl halides by a metal-free photoredox-catalyzed coupling. These ligand-free methodologies significantly expand the chem. space of the Mizoroki-Heck coupling. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Computed Properties of C7H6FIO).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Computed Properties of C7H6FIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The use of biochemical and biophysical tools for triage of high-throughput screening hits – a case study with Escherichia coli phosphopantetheine adenylyltransferase was written by Miller, J. Richard;Thanabal, Venkataraman;Melnick, Michael M.;Lall, Manjinder;Donovan, Charles;Sarver, Ronald W.;Lee, Doh-Yeel;Ohren, Jeff;Emerson, Don. And the article was included in Chemical Biology & Drug Design in 2010.Recommanded Product: 20776-54-9 This article mentions the following:

High-throughput screening is utilized by pharmaceutical researchers and, increasingly, academic investigators to identify agents that act upon enzymes, receptors, and cellular processes. Screening hits include mols. that specifically bind the target and a greater number of non-specific compounds It is necessary to ‘triage’ these hits to identify the subset worthy of further exploration. As part of our antibacterial drug discovery effort, we applied a suite of biochem. and biophys. tools to accelerate the triage process. We describe application of these tools to a series of 9-oxo-4,9-dihydropyrazolo[5,1-b]quinazoline-2-carboxylic acids (PQ) hits from a screen of Escherichia coli phosphopantetheine adenylyltransferase (PPAT). Initial confirmation of specific binding to phosphopantetheine adenylyltransferase was obtained using biochem. and biophys. tools, including a novel orthogonal assay, isothermal titration calorimetry, and saturation transfer difference NMR. To identify the phosphopantetheine adenylyltransferase sub-site bound by these inhibitors, two techniques were utilized: steady-state enzyme kinetics and a novel ¹⁹F NMR method in which fluorine-containing fragments that bind the ATP and/or phosphopantetheine sites serve as competitive reporter probes. These data are consistent with PQs binding the ATP sub-site. In addition to identification of a series of PPAT inhibitors, the described hit triage process is broadly applicable to other enzyme targets in which milligram quantities of purified target protein are available. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Recommanded Product: 20776-54-9).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 20776-54-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On the balance between nematic and smectic phases in 2′,3′-difluoro-4,4″-dialkyl-p-terphenyls was written by Wachala, Agata;Pytlarczyk, Marta;Kula, Przemyslaw. And the article was included in Liquid Crystals in 2019.Formula: C6H3F2I This article mentions the following:

The full homologous series of 2′,3′-difluoro-4,4”-dialkyl-p-terphenyls, where alkyl chains are from Me to nonyl length, have been synthesized and mesomorphic properties, phase transition temperatures and enthalpies were measured. The influence of the terminal chain length on thermal mesophase range, phase sequence has been analyzed and discussed. The odd-even and sym.-non-sym. effects have also been studied and its influence on smectic to nematic balance was analyzed. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Formula: C6H3F2I).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C6H3F2I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective C(sp³)-H and C(sp²)-H Fluorination of Alcohols Using Practical Auxiliaries was written by Mao, Yang-Jie;Lou, Shao-Jie;Hao, Hong-Yan;Xu, Dan-Qian. And the article was included in Angewandte Chemie, International Edition in 2018.Application In Synthesis of 1-Bromo-4-(2-iodoethyl)benzene This article mentions the following:

Selective introduction of fluorine into mols. by the cleavage of inert C-H bonds is of central academic and synthetic interest, yet remains challenging. Given the central role of alcs. in organic chem. as the most ubiquitous building blocks, a versatile and selective C(sp³)-H and C(sp²)-H fluorination of simple alcs., enabled by novel designed exo-directing groups, is described. C(sp²)-H bond fluorination was achieved by using a simple acetone oxime as auxiliary, whereas a new, modular and easily accessible bidentate auxiliary was developed for the efficient and site-selective fluorination of various primary Me, methylene, and benzylic C(sp³)-H bonds. Fluorinated alcs. can readily be accessed by the removal of auxiliaries, and significantly expands the synthetic prospect of the present procedure. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Application In Synthesis of 1-Bromo-4-(2-iodoethyl)benzene).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application In Synthesis of 1-Bromo-4-(2-iodoethyl)benzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electrophilic aromatic substitution. 26. Regioselective halo- and carbodesilylation of (trimethylsilyl)-1-methylpyrazoles was written by Effenberger, Franz;Krebs, Andreas. And the article was included in Journal of Organic Chemistry in 1984.SDS of cas: 34091-51-5 This article mentions the following:

The isomeric 3-, 4-, and 5-(trimethylsilyl)- (I) as well as the 3,4- (II), 3,5- (III), and 4,5-bis(trimethylsilyl)-1-methylpyrazoles (IV) are obtained by methylation of the corresponding (trimethylsilyl)-1H-pyrazoles or by silylation of Grignard or lithio derivatives of appropriate 1-methylpyrazoles with ClSiMe₃. II and IV are halodesilylated regioselectively in the 4-position by Br or ICl, yielding V (R = SiMe₃, R¹ = H; R = H, R¹ = SiMe₃). With addnl. Br, these monobromo compounds suffer exclusively bromodesilylation to give 3,4- and 4,5-dibromo-1-methylpyrazole. These findings are in accord with the electrophilic substitution reactivity indexes for 1-methylpyrazole and with the ipso-directing influence of the Me₃Si group. The reaction of II with I₂, unexpectedly, occurs preferentially at the 3-position. Regioselective carbodesilylation in the 5-position is observed in the fluoride-catalyzed reactions of I, III, and IV with electrophiles. The high regiospecificity of this reaction is rationalized in terms of carbanion stabilization at the individual pyrazole positions. In the experiment, the researchers used many compounds, for example, 5-Iodo-1-methyl-1H-pyrazole (cas: 34091-51-5SDS of cas: 34091-51-5).

5-Iodo-1-methyl-1H-pyrazole (cas: 34091-51-5) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.SDS of cas: 34091-51-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Modular C-H Functionalization Cascade of Aryl Iodides was written by Shi, Hang;Babinski, David J.;Ritter, Tobias. And the article was included in Journal of the American Chemical Society in 2015.HPLC of Formula: 133232-56-1 This article mentions the following:

We report the first example of ipso-borylation for the modular 1,2-bisfunctionalization of aryl iodides via C-H functionalization. The carbon-boron bond is used as a lynch pin to access ipso carbon-carbon, carbon-nitrogen, carbon-oxygen, and carbon-halogen (Cl, Br, I) bonds. The utility of our methodol. is illustrated through quick, modular syntheses of the pharmaceuticals Abilify and Flunixin. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1HPLC of Formula: 133232-56-1).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.HPLC of Formula: 133232-56-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Phenylpropiolic acids. VIII. Self-condensation of 3-halo-4-methoxyphenylpropiolic acids was written by Baddar, Fawzi G.;Moussa, G. E. M.;Omar, M. T.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1968.COA of Formula: C8H7IO2 This article mentions the following:

3-Halo-4-methoxyphenylpropiolic acids are converted by Ac2O into a mixture of 6- and 8-halo-7-methoxy-1-(3-halo-4-methoxyphenyl)naphthalene-2,3-dicarboxylic anhydrides. The structure of 6-bromo-7-methoxy-1-(3-bromo-4 – methoxyphenyl)naphthalene-2,3-dicarboxylic anhydride was established by its conversion into the corresponding 6,7-dimethoxy derivative The structure of the remaining anhydrides were established by ir and uv spectroscopy. The anhydrides are isomerized by AlCl3 to the corresponding 7H-benzo[c]fluoren-7-one. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6COA of Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.COA of Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Migratory Hydrogenation of Terminal Alkynes by Base/Cobalt Relay Catalysis was written by Liu, Xufang;Liu, Bingxue;Liu, Qiang. And the article was included in Angewandte Chemie, International Edition in 2020.HPLC of Formula: 85356-68-9 This article mentions the following:

Migratory functionalization of alkenes has emerged as a powerful strategy to achieve functionalization at a distal position to the original reactive site on a hydrocarbon chain. However, an analogous protocol for alkyne substrates is yet to be developed. Herein, a base and cobalt relay catalytic process for the selective synthesis of (Z)-2-alkenes and conjugated E alkenes by migratory hydrogenation of terminal alkynes is disclosed. Mechanistic studies support a relay catalytic process involving a sequential base-catalyzed isomerization of terminal alkynes and cobalt-catalyzed hydrogenation of either 2-alkynes or conjugated diene intermediates. Notably, this practical non-noble metal catalytic system enables efficient control of the chemo-, regio-, and stereoselectivity of this transformation. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9HPLC of Formula: 85356-68-9).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.HPLC of Formula: 85356-68-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aliphatic C-H Bond Iodination by a N-Iodoamide and Isolation of an Elusive N-Amidyl Radical was written by Artaryan, Alexander;Mardyukov, Artur;Kulbitski, Kseniya;Avigdori, Idan;Nisnevich, Gennady A.;Schreiner, Peter R.;Gandelman, Mark. And the article was included in Journal of Organic Chemistry in 2017.Application of 10297-05-9 This article mentions the following:

Contrary to C-H chlorination and bromination, the direct iodination of alkanes represents a great challenge. We reveal a new N-iodoamide that is capable of a direct and efficient C-H bond iodination of various cyclic and acyclic alkanes providing iodoalkanes in good yields. This is the first use of N-iodoamide for C-H bond iodination. The method also works well for benzylic C-H bonds, thereby constituting the missing version of the Wohl-Ziegler iodination reaction. Mechanistic details were elucidated by DFT computations, and the N-centered radical derived from the used N-iodoamide, which is the key intermediate in this process, was matrix-isolated in a solid argon matrix and characterized by UV-vis as well as IR spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Application of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-Catalyzed Azide-Ynamide Cyclization to Generate α-Imino Copper Carbenes: Divergent and Enantioselective Access to Polycyclic N-Heterocycles was written by Liu, Xin;Wang, Ze-Shu;Zhai, Tong-Yi;Luo, Chen;Zhang, Yi-Ping;Chen, Yang-Bo;Deng, Chao;Liu, Rai-Shung;Ye, Long-Wu. And the article was included in Angewandte Chemie, International Edition in 2020.Category: iodides-buliding-blocks This article mentions the following:

Here an efficient copper-catalyzed cascade cyclization of azide-ynamides via α-imino copper carbene intermediates is reported, representing the first generation of α-imino copper carbenes from alkynes. This protocol enables the practical and divergent synthesis of an array of polycyclic N-heterocycles, e.g., I, in generally good to excellent yields with broad substrate scope and excellent diastereoselectivities. Moreover, an asym. azide-ynamide cyclization has been achieved with high enantioselectivities (up to 98:2 e.r.) by employing BOX-Cu complexes as chiral catalysts. Thus, this protocol constitutes the first example of an asym. azide-alkyne cyclization. The proposed mechanistic rationale for this cascade cyclization is further supported by theor. calculations In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Category: iodides-buliding-blocks).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com