Iodides-buliding-blocks

Reductive Hydroxymethylation of 4-Heteroarylpyridines was written by Hepburn, Hamish B.;Donohoe, Timothy J.. And the article was included in Chemistry – A European Journal in 2020.COA of Formula: C4H8ClI This article mentions the following:

The activation of pyridinium salts with electron-withdrawing heterocycles enabled an iridium-catalyzed reductive hydroxymethylation reaction to proceed smoothly, facilitating the preparation of useful 3D heteroaryl-substituted functionalized piperidines. The methodol. was used to prepare 3-hydroxymethylated analogs of pharmaceutical agents. Mechanistically, formaldehyde acts as both a hydride donor and the electrophile, leading to the formation of two new carbon-hydrogen bonds and one new carbon-carbon bond under relatively mild conditions. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9COA of Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.COA of Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Distannane mediated reaction of N-acyliminium ion pools with alkyl halides. A chain mechanism involving radical addition followed by electron transfer was written by Maruyama, Tomokazu;Suga, Seiji;Yoshida, Jun-ichi. And the article was included in Tetrahedron in 2006.Recommanded Product: 10297-05-9 This article mentions the following:

Hexabutyldistannane is an effective mediator allowing the reaction of N-acyliminium ion pools with alkyl halides. A chain mechanism involving the addition of an alkyl radical generated from an alkyl halide to an N-acyliminium ion followed by the 1-electron reduction of the resulting radical-cation by distannane was proposed. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cu-catalyzed decarboxylative iodination of aryl carboxylic acids with NaI: A practical entry to aryl iodides under aerobic conditions was written by Fu, Zhengjiang;Jiang, Yongqing;Jiang, Ligao;Li, Zhaojie;Guo, Shengmei;Cai, Hu. And the article was included in Tetrahedron Letters in 2018.Recommanded Product: 4-Chloro-2-iodo-1-nitrobenzene This article mentions the following:

A simple and practical Cu-catalyzed decarboxylative iodination has been well established under aerobic condition, which provides a useful method to synthesize aryl iodides in moderate to good yields with the use of (hetero)aryl carboxylic acids and NaI as starting materials [e.g., 4-chloro-2-nitrobenzoic acid â†?4-chloro-1-iodo-2-nitrobenzene (80%) using NaI in presence of Cu(OAc)₂, 1,10-Phen and O₂ in DMSO]. Thiabendazole has been prepared via a three-step procedure to show synthetic practicability of the protocol. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Recommanded Product: 4-Chloro-2-iodo-1-nitrobenzene).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 4-Chloro-2-iodo-1-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-Catalyzed protecting-group-free cross-couplings of iodophenols with atom-economic triarylbismuth reagents was written by Rao, Maddali L. N.;Meka, Suresh. And the article was included in Tetrahedron Letters in 2020.SDS of cas: 207115-22-8 This article mentions the following:

An efficient protocol for the protecting-group-free synthesis of unsym. hydroxybiaryls ArAr¹ [Ar = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; Ar¹ = 2-HOC₆H₄, 4-HOC₆H₄, 2-HO-5-BrC₆H₃, etc.] via the Pd-catalyzed cross-couplings of unprotected iodophenols with triarylbismuth reagents was described. The presented protocols exhibited good to high yields of hydroxybiaryls. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8SDS of cas: 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.SDS of cas: 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic Asymmetric Homologation of α-Ketoesters with α-Diazoesters: Synthesis of Succinate Derivatives with Chiral Quaternary Centers was written by Li, Wei;Liu, Xiaohua;Tan, Fei;Hao, Xiaoyu;Zheng, Jianfeng;Lin, Lili;Feng, Xiaoming. And the article was included in Angewandte Chemie, International Edition in 2013.Product Details of 10297-05-9 This article mentions the following:

In the presence of Y(OTf)₃ and proline- or pipecolic acid-derived N,N’-dioxide ligand, the first catalytic asym. homologation of α-ketoesters R¹C(O)CO₂Me (R¹ = Me, Ph, 3-MeC₆H₄, 4-H₂C:CHC₆H₄, piperonyl, 2-naphthyl, etc.) with α-diazo esters R²C(N₂)CO₂Ad [Ad = 1-adamantyl; R² = Me, Et, n-decyl, H₂C:CHCH₂, HCCHCH₂, N₃(CH₂)₃, etc.] through either a 1,2-aryl or 1,2-alkyl shift was accomplished. Highly functionalized succinate derivatives MeO₂CC(O)CR¹R²CO₂Ad containing a quaternary stereocenter were obtained in excellent yields and with good enantioselectivities under mild conditions. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Product Details of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Product Details of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Construction of Halogen-Bonded Organic Frameworks (XOFs) as Novel Efficient Iodinating Agents was written by Xia, Ning;Han, Jixin;Xie, Fei;Gong, Guanfei;Wang, Lu;Wang, Jike;Chen, Shigui. And the article was included in ACS Applied Materials & Interfaces in 2022.Name: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

The structural diversity and the various applications of organic frameworks have attracted much attention in recent years. Recently, halogen-bonded organic frameworks (XOFs) became a novel member of these materials, thereby facilitating the exploration of the interesting structures as well as functions. Here the authors present two types of [N···I⁺···N] connected XOFs (XOF-TPy and XOF-TPEB) with two tridentate ligands , 1,3,5-tri(pyridin-4-yl)benzene (TPy) and 1,3,5-tri-4-pyridyl-1,2-ethenylbenzene (TPEB), as building blocks. XOF-TPy and XOF-TPEB were characterized by ¹H NMR, UV-vis, XPS, IR, SEM, and HR-TEM. Two-dimensional (2D) structural models were established based on powder X-ray diffraction (PXRD) data and theor. simulations. Further experiment showed that these XOFs were excellent iodinating agents for the substituted arylboronic acids with either the electron-donating or electron-withdrawing groups upon heating without any catalyst. This research not only brings further understanding to the XOFs but also extends the applications of XOFs. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Name: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Name: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Two-point halogen bonding between 3,6-dihalopyromellitic diimides was written by Cao, Dennis;Hong, Michael;Blackburn, Anthea K.;Liu, Zhichang;Holcroft, James M.;Stoddart, J. Fraser. And the article was included in Chemical Science in 2014.HPLC of Formula: 3268-21-1 This article mentions the following:

The syntheses of 3,6-dichloro-, -dibromo-, and -diiodopyromellitic diimides-ACl, ABr, and AI, resp.-have been achieved. X-Ray crystallog. of single crystals of ACl and ABr unveils the formation of extensive halogen-bonding networks in the solid state as a consequence of interactions between the lone pairs on the carbonyl oxygen atoms with the σ-holes of the halogen atoms. Further, the solid-state superstructure of diiodopyromellitic diimide is characterized by the formation of associated halogen-π dimers. The co-crystallization of ACl or ABr with a 1,5-diaminonaphthalene derivative DN yields co-crystals of a mixed-stack charge-transfer (CT) complex which are supported by an expansive hydrogen-bonded network in addition to halogen-bonded belts that bring adjacent mixed-stacks into association with each other. 2,6-Dimethoxynaphthalene (DO) proved to be an effective CT complement to AI, yielding solvent-free co-crystals with superstructures which are comprised of a 1 : 2 ratio of AI to DO. This dimeric halogen-bonding motif is reminiscent of the formation of hydrogen-bonded dimers between carboxylic acids. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1HPLC of Formula: 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.HPLC of Formula: 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

5-Chloro- and 5,6-dichloronicotinic acids was written by Graf, Roderich;Lederer-Ponzer, Ernst;Kopetz, Viktor;Purkert, Renato;Laszlo, Paul. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1933.HPLC of Formula: 15366-65-1 This article mentions the following:

Nicotinic acid HCl salt (100 g.) and 180 g. SOCl₂, gently boiled 5 days and then heated in tubes 12 hrs. at 180°, give 50-60% of a mixture of the 5-Cl and 5,6-di-Cl derivatives (I), in about equal amounts; more SOCl₂ increases the proportion of the di-Cl acid. 5-Aminopyridine-3-carboxylic acid (II), m. 288-90° (decomposition). II through the diazo reaction gives the 5-Br derivative, m. 182-3°; chloride, m. 74-5°; Me ester, m. 98-9°; Ph ester, m. 86-7°. The chloride and N₂H₄.H₂O in C₆H₆ give sym-bis(5-bromo-3-pyridoyl)hydrazine, m. 308° (decomposition). The Me ester gives 5-bromopyridine-3-carbonyl hydrazide, m. 193-4° (benzal derivative, m. 191-3°); the azide m. 88-9° (decomposition) and with absolute EtOH gives 5-bromo-3-carbethoxyaminopyridine, m. 150-1°; Me ester, m. 169-70°; heating the Et ester with 30% NaOH gives 5-bromo-3-aminopyridine (III), b₁₂ 149-50°, m. 66-7°; the intermediate Na 5-bromo-3-pyridylcarbamate was also analyzed; Ac derivative of III, m. 127-8° (dihydrate, m. 76-8°); picrate of III, deep yellow, m. 212-3°; chloroaurate, red-orange, m. 185-7°. 5-Iodopyridine-3-carboxylic acid, m. 220°; Ph ester, m. 100-1° Me ester, m. 121°; Et ester, m. 86-7°; amide, m. 221-2°. 5-Hydroxypyridine-3-carboxylic acid, m. 299° (decomposition). The Et ester of I and N₂H₄.H₂O give Et 5-chloro-6-hydrazinopyridine-3-carboxylate (IV), m. 137-8°; the hydrazide, gray, m. 238-40°; the free acid m. 248-9° and was also obtained directly from I. IV on diazotizing yields Et 5-chlorobenzotetrazole-3-carboxylate, m. 95-6°; the free acid m. 195-6°; heating with HCO₂H gives 5-chlorobenzotriazole-3-carboxylic acid, m. above 300°. I and concentrated NH₄OH at 180-90° give 6-amino-5-chloropyridine-3-carboxylic acid, m. 323° (decomposition); Me ester, m. 163-5°; the Me ester of the 6-HO derivative m. 218°. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1HPLC of Formula: 15366-65-1).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.HPLC of Formula: 15366-65-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A unified synthetic strategy for the indolopyridine alkaloid group was written by Lavilla, Rodolfo;Gullon, Francisco;Bosch, Joan. And the article was included in European Journal of Organic Chemistry in 1999.Synthetic Route of C6H4INO2 This article mentions the following:

Thermal or AcCl-induced cyclization of bromo enamide I (R, R¹ = H; R² = Br) 10 affords the pentacyclic derivative I (RR¹ = bond, R² = Br) 12 with high yield and regioselectivity. From this common synthetic intermediate, Pd-catalyzed reactions allow the total synthesis of indolopyridine alkaloids I (RR¹ = bond; R² = CH:CH₂, Et, Ac, CHMeOMe). In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Synthetic Route of C6H4INO2).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Synthetic Route of C6H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com