Tag: 200-300

Regioselective iodination of arenes using iodine/NaBO₃.4H₂O system in ionic liquid was written by Bhilare, Sachin V.;Deorukhkar, Amol R.;Darvatkar, Nitin B.;Salunkhe, Manikrao M.. And the article was included in Synthetic Communications in 2008.Application of 207115-22-8 This article mentions the following:

A mild, efficient, and simple protocol was developed for iodination of arenes and heterocyclic compounds with mol. iodine catalyzed by sodium perborate in ionic liquid The methodol. offered iodoarenes in good to excellent yields at room temperature The protocol proved to be highly selective, as a single isomer was formed exclusively in most of the substrates. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application of 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ambient-Temperature Ortho C-H Arylation of Benzoic Acids with Aryl Iodides with Ligand-Supported Palladium Catalyst was written by Zhu, Changlei;Zhang, Yuanfei;Kan, Jian;Zhao, Huaiqing;Su, Weiping. And the article was included in Organic Letters in 2015.Synthetic Route of C8H9IO2 This article mentions the following:

The ambient-temperature ortho C-H arylation of electron-deficient benzoic acids with aryl iodides has been achieved by using an Ac-Ile-OH-supported Pd catalyst. A wide range of unactivated benzoic acids could cross-couple an array of aryl iodides in moderate to excellent yields. The choice of HFIP as a solvent is crucial to realizing the mild C-H arylation, and the beneficial effect of the ligand on the reaction likely stems from the accelerated C-H activation process and the improved catalyst lifetime. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Synthetic Route of C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Trifunctionalization of Aryl Iodides with Two Distinct Nitrogen and Carbon Electrophiles by Palladium/Norbornene Catalysis was written by Wang, Jing;Wang, Hui;Wang, Zihan;Li, Linqiang;Qin, Cheng;Luan, Xinjun. And the article was included in Chinese Journal of Chemistry in 2021.Formula: C6H4ClIO This article mentions the following:

Herein, a highly chemo- and regioselective vicinal trifunctionalization of aryl iodides by palladium/norbornene (Pd/NBE) catalysis is reported. The key feature of this new method is the introduction of two distinct nitrogen and carbon electrophiles, with a large gap in reactivity, for ortho-unsubstituted aryl iodides via an intermol. and intramol. C-H functionalization, resp. Eight types of ipso terminations can be coupled with both ortho-amination and ortho-alkylation, affording a variety of polysubstituted benzoheterocyclic scaffolds. Silicon-tethered substrates can lead to polyfucntional arenes via a single-step operation. Noteworthy, these products exhibit full-color-tunable strong fluorescence emissions with large Stokes shifts, and product I can serve as a fluorescent probe to specifically target lysosome in living cells. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-iodophenol (cas: 289039-26-5Formula: C6H4ClIO).

2-Chloro-5-iodophenol (cas: 289039-26-5) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C6H4ClIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Photocatalytic C-H silylation of heteroarenes by using trialkylhydrosilanes was written by Liu, Shihui;Pan, Peng;Fan, Huaqiang;Li, Hao;Wang, Wei;Zhang, Yongqiang. And the article was included in Chemical Science in 2019.Application of 5460-32-2 This article mentions the following:

The efficient and selective C-H silylation of heteroarenes, especially the pharmaceutically relevant electron-deficient heteroarenes, represents a great challenge in organic synthesis. Herein we wish to report a distinctive visible light-promoted photocatalytic C-H silylation approach that enables the direct coupling of trialkylhydrosilanes with both electron-deficient and -rich heteroarenes as well as with cyano-substituted arenes in moderate to high yields and with good regioselectivity. The protocol features operational simplicity, mild reaction conditions, and the use of safe and readily available Na₂S₂O₈, bis(trimethylsilyl) peroxide (BTMSPO) or ⁱPr₃SiSH as the radical initiators. Notably, the challenging bulky and inert trialkylhydrosilanes, such as (t-butyldimethyl)silane (^tBuMe₂SiH) and (triisopropyl)silane (ⁱPr₃SiH), work smoothly with the protocol. Moreover, despite the higher stability of ^tBuMe₂Si silylation products, our studies revealed their great reactivity and versatility in diverse C-Si-based chem. transformations, providing an operationally simple, low-cost, and environmentally benign synthetic technol. for mol. construction and elaboration. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Facile Benzo-Ring Construction via Palladium-Catalyzed Functionalization of Unactivated sp³ C-H Bonds under Mild Reaction Conditions was written by Feng, Yiqing;Wang, Yuji;Landgraf, Bradley;Liu, Shi;Chen, Gong. And the article was included in Organic Letters in 2010.Recommanded Product: 207115-22-8 This article mentions the following:

A practical synthetic method for the annulation of benzo-rings by the intramol. coupling of an aryl iodide and a methylene C-H bond is described. The palladium-catalyzed C-H functionalization is directed by an aminoquinoline carboxamide group, which can be easily installed (to form, e.g, I) and removed. High yields and broad substrate scope were achieved. An additive of ortho-Ph benzoic acid, identified from a systematic screening, functions as a critical ligand for the catalytic process under mild condition, even at near room temperature In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Recommanded Product: 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Recommanded Product: 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Elucidation of the Structure of a Highly Active Catalytic System for CO₂/Epoxide Copolymerization: A salen-Cobaltate Complex of an Unusual Binding Mode was written by Na, Sung Jae;S, Sujith;Cyriac, Anish;Kim, Bo Eun;Yoo, Jina;Kang, Youn K.;Han, Su Jung;Lee, Chongmok;Lee, Bun Yeoul. And the article was included in Inorganic Chemistry in 2009.Name: 1-Chloro-4-iodobutane This article mentions the following:

Salen-type ligands comprised of ethylenediamine or 1,2-cyclohexenediamine, along with an salicylaldehyde bearing a Me substituent on its 3-position and a -[CR(CH₂CH₂CH₂N⁺Bu₃)₂] (R=H or Me) on its 5-position, unexpectedly afford cobalt(III) complexes with uncoordinated imines. In these complexes, two salen-phenoxys and two 2,4-dinitrophenolates (DNPs), which counter the quaternary ammonium cations, coordinate persistently with cobalt, while two other DNPs are fluxional between a coordinated and an uncoordinated state in THF at room temperature The complexes of this binding mode show excellent activities in carbon dioxide/propylene oxide copolymerization (TOF, 8 300-13 000 h^-1) but with some fluctuation in induction times (1-10 h), depending on how dry the system is. The induction time is shortened (<1.0 h) and activity is increased ∼1.5 times upon the replacement of the two fluxional DNPs with 2,4-dinitrophenol-2,4-dinitrophenolate homoconjugation ([DNP···H···DNP]^–). Imposing steric congestion either by replacing the Me substituent on the salicylaldehyde with tert-Bu or by employing H₂NCMe₂CMe₂NH₂ instead of ethylenediamine or 1,2-cyclohexenediamine results in conventional imine-coordinating complexes, which show lower activities than uncoordinated imine complexes. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ligand-Enabled Gold-Catalyzed C(sp²)-S Cross-Coupling Reactions was written by Tathe, Akash G.;Patil, Nitin T.. And the article was included in Organic Letters in 2022.COA of Formula: C8H9IO2 This article mentions the following:

C(sp²)-S cross-coupling reactions of aryl iodides and arylsulfonyl hydrazides under ligand-enabled, Au(I)/Au(III) redox catalysis was reported. This strategy operates under mild reaction conditions, requires no prefunctionalized aryl coupling partner and works across several aryl iodides. The reaction mechanism was supported with control experiments, mass spectrometry, and NMR studies. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.COA of Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ligand-Controlled Regiodivergent Hydroalkylation of Pyrrolines was written by Qian, Deyun;Hu, Xile. And the article was included in Angewandte Chemie, International Edition in 2019.Quality Control of 1-Chloro-4-iodobutane This article mentions the following:

Two series of C-alkylated pyrrolidines I [R = Boc, Cbz; R¹ = i-Pr, cyclopentyl, indol-1-yl, etc.] and II [R² = CO₂Ph, Boc, Cbz; R³ = cyclohexyl, (CH₂)₃Ph, 2-thienyl, etc.] were synthesized via ligand controlled nickel-catalyzed regiodivergent hydroalkylation of 3-pyrrolines with alkyl/aryl halides. This method demonstrated broad scope and high functional-group tolerance and could be applied in late-stage functionalizations. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Quality Control of 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Quality Control of 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schmidt Reaction of ω-Azido Valeryl Chlorides Followed by Intermolecular Trapping of the Rearrangement Ions: Synthesis of Assoanine and Related Pyrrolophenanthridine Alkaloids was written by Ding, Shao-Lei;Ji, Yang;Su, Yan;Li, Rui;Gu, Peiming. And the article was included in Journal of Organic Chemistry in 2019.Formula: C8H9IO2 This article mentions the following:

The Schmidt reaction of ω-azido valeryl chlorides in the presence of an addnl. nucleophile was explored. The arenes, alcs., and amines were demonstrated as the intermol. trapping reagents for isocyanate ion and N-acyliminium ion from the Schmidt rearrangement, affording the corresponding products with moderate to excellent yields. Two 2-oxoindoles from the reaction were successfully converted into four natural alkaloids, namely, assoanine, anhydrolycorine, oxoassoanine, and anhydrolycorinone. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The Synthesis of 1H-Pyrazolo[3,4-b]quinoxaline Derivatives Oriented towards Modification of Carbocyclic Ring in the Parent Skeleton was written by Wojtasik, Katarzyna;Danel, Andrzej. And the article was included in ChemistrySelect in 2020.Safety of 4-Chloro-2-iodo-1-nitrobenzene This article mentions the following:

It was proved that the method of synthesis of 1H-pyrazolo[3,4-b]quinoxaline derivatives I [R¹ = 5-Cl, 6-N(Et)₂, 7-N(Et)₂, etc.] (PQX), consisting of the reductive cyclization of the corresponding pyrazole derivative II [R² = 5-Cl, 6-Cl, 7-Cl, 8-Cl] was the most universal method of PQX synthesis among the known and was regiospecific. The obtained x-chloro-1-methyl-3-phenyl-1H-pyrazolo[3,4-b]quinoxaline I [R¹ = 5-Cl, 6-Cl, 7-Cl, 8-Cl, etc.] isomers were starting materials for the synthesis of N,N-diethylamine derivatives I [R¹ = 5-N(Et)₂, 6-N(Et)₂, 7-N(Et)₂, 8-N(Et)₂, etc.]. The position differentiation of these substituents strongly impacted the emissive properties of the final compounds In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Safety of 4-Chloro-2-iodo-1-nitrobenzene).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Safety of 4-Chloro-2-iodo-1-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com