Tag: 200-300

Domino Suzuki coupling and condensation reaction: an efficient strategy towards synthesis of phenanthridines was written by Ghosh, Munmun;Ahmed, Atiur;Singha, Raju;Ray, Jayanta K.. And the article was included in Tetrahedron Letters in 2015.Application of 220185-63-7 This article mentions the following:

A short and convenient hetero-annulation protocol was developed for the synthesis of substituted phenanthridines via domino Suzuki coupling and condensation between N-(2-iodo-aryl)-formamide derivatives and 2-formylphenylboronic acid in the presence of Pd(OAc)₂, Cs₂CO₃ and PPh₃ as catalytic system in dry DMF at 85-90° for 6-7 h. The intermediate after Suzuki coupling and deprotection of nitrogen under the same catalytic system, furnishes the corresponding phenanthridines in good yields after immediate condensation and dehydration. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Application of 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application of 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of ¹²⁵I-imaging agents was written by Sloan, Nikki L.;Luthra, Sajinder K.;McRobbie, Graeme;Pimlott, Sally L.;Sutherland, Andrew. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Electric Literature of C6H3ClINO2 This article mentions the following:

An operationally simple, one-pot, two-step tandem procedure was described which allowed the incorporation of radioactive iodine [¹²⁵I] into aryl amines to yield radioiodine labeled arenes, e.g., I via stable diazonium salts formation. The mild conditions were tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of ¹²⁵I-labeled aryl compounds and SPECT radiotracers. In particular, this process allowed the preparation of a range of important SPECT imaging agents, including [¹²⁵I]iomazenil, [¹²⁵I]CNS1261 and [¹²⁵I]IBOX. Also, the first radiosynthesis of a high affinity agent of TSPO which could be used to study neuroinflammation was reported. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Electric Literature of C6H3ClINO2).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Electric Literature of C6H3ClINO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

γ-Carboline synthesis enabled by Rh(III)-catalyzed regioselective C-H annulation was written by Jiang, Bo;Jia, Jingwen;Sun, Yufei;Wang, Yichun;Zeng, Jing;Bu, Xiubin;Shi, Liangliang;Sun, Xiaoying;Yang, Xiaobo. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

A redox-neutral Rh(III)-catalyzed C-H annulation of indolyl oximes were developed. The reaction exhibited a reverse regioselectivity, thus gave an exclusive and easy way for the synthesis of a wide range of substituent free γ-carbolines at C3 position with high efficiency. Deuterium-labeling experiments and kinetic anal. were preliminarily shed light on the working mode of this catalytic system. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The Asymmetric Synthesis of Amines via Nickel-Catalyzed Enantioconvergent Substitution Reactions was written by Yang, Ze-Peng;Freas, Dylan J.;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2021.Recommanded Product: 1-Chloro-4-iodobutane This article mentions the following:

Herein, two mild methods was reported for the catalytic enantioconvergent synthesis of protected dialkyl carbinamines such as RCHXR¹ [R = i-Bu, n-hexyl, (CH₂)₅F, etc.; R¹ = Et, i-Bu, (CH₂)₂Ph, etc.; X = NHBoc, Phth, NHFmoc, etc.], both of which use a chiral nickel catalyst to couple an alkylzinc reagent with α-phthalimido alkyl chloride or an N-hydroxyphthalimide (NHP) ester of a protected α-amino acid. The methods were versatile, providing dialkyl carbinamine derivatives that bear an array of functional groups. Further, for couplings of NHP esters a one-pot variant wherein the NHP ester was generated in situ, allowing the generation of enantioenriched protected dialkyl carbinamines in one step from com. available amino acid derivatives was also described. The utility of this method by applying it to the efficient catalytic enantioselective synthesis of a range of interesting target mols. was demonstrated. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Potential hypolipidemic agents. III. Heterocyclic compounds affecting free fatty acid mobilization in vivo was written by Carlson, Lars A.;Hedbom, Christina;Helgstrand, Erik;Sjoberg, Berndt;Stjernstrom, Nils E.. And the article was included in Acta Pharmaceutica Suecica in 1972.Recommanded Product: 15366-65-1 This article mentions the following:

Compounds such as 3-methyl-5-isoxazolecarboxylic acid [4857-42-5], 5-fluoronicotinic acid [402-66-4], 5-fluoro-3-pyridylacetic acid [38129-24-7], and 3-methylpyrazole [1453-58-3] exhibited the highest inhibition of free fatty acid mobilization in blood among 188 heterocyclic compounds tested in dogs, while compounds such as 5-methyl-3-isoxazolecarboxylic acid [3405-77-4], 2-fluoronicotinic acid [393-55-5], and 3-aminobenzoic acid [99-05-8] had no effect on free fatty acid mobilization. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Recommanded Product: 15366-65-1).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 15366-65-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed annulation reactions of methyl o-halobenzoates with azabicyclic alkenes: a general protocol for the construction of benzo[c]phenanthridine derivatives was written by Guo, Cui;Huang, Kanglun;Wang, Bo;Xie, Longguang;Xu, Xiaohua. And the article was included in RSC Advances in 2013.SDS of cas: 123278-03-5 This article mentions the following:

The annulation reaction of Me o-halobenzoates with azabicyclic alkenes proceeds efficiently to give the corresponding benzo[c]phenanthridine derivatives in good to excellent yields using a developed base-free methodol. based on our preliminary studies. Thirty-seven application examples validate the compatibility of the present strategy with different groups, particularly with the electron-deficient ones, that are difficult to access using other traditional methods. In addition, annulation reactions with non-sym. azabicyclic alkenes are achieved in high regioselectivity. In the experiment, the researchers used many compounds, for example, 3-Chloro-2-iodobenzoic acid (cas: 123278-03-5SDS of cas: 123278-03-5).

3-Chloro-2-iodobenzoic acid (cas: 123278-03-5) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.SDS of cas: 123278-03-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors was written by Li, Xiaoyan;Yin, Wenyuan;Sarma, P. V. V. Srirama;Zhou, Hao;Ma, Jun;Cook, James M.. And the article was included in Tetrahedron Letters in 2004.SDS of cas: 220185-63-7 This article mentions the following:

The first stereoselective synthesis of optically active 6-chloro-L-tryptophan, 5-nitro-D-tryptophan, 6-nitro-D-tryptophan, 5,6-dichloro-L-tryptophan, 6-aza-D-tryptophan, as well as the first synthesis of the optically active 7-methoxy-D-tryptophan with potential activity at IDO (IDO = indoleamine 2,3-dioxygenase) via the Schollkopf chiral auxiliary is described. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7SDS of cas: 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.SDS of cas: 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Effect of Water on the Functionalization of Substituted Anisoles with Iodine in the Presence of F-TEDA-BF₄ or Hydrogen Peroxide was written by Pavlinac, Jasminka;Zupan, Marko;Stavber, Stojan. And the article was included in Journal of Organic Chemistry in 2006.Computed Properties of C8H7IO2 This article mentions the following:

Water was found to be a convenient reaction medium for functionalization of substituted anisoles using iodine in the presence of Selectfluor (F-TEDA-BF₄) or hydrogen peroxide as mediators and oxidizers. Two types of functionalization were observed: iodination or oxidation In the iodination process, two reaction routes were established. In the case of the first route, a high iodine atom economy was achieved for selective and effective iodo functionalization with a stoichiometric ratio of substrate/iodine/(mediator/oxidizer) = 2:1:1.2. An electrophilic iodination reaction process was suggested for this route, with the oxidizer converting the liberated iodide anion to iodine. For the second reaction route, a stoichiometric ratio of substrate/iodine/(mediator/oxidizer) = 1:1:1 and a lower iodine atom economy were observed; in this case, ion radical formation in the first step of the reaction was suggested. Iodine was found to be an effective catalyst for the oxidation of a hydroxy benzyl functional group to benzaldehyde using F-TEDA-BF₄. Water is an effective medium for functionalization of anisole, p-methoxybenzyl alc., 1-(4-methoxyphenyl)ethanone, o-dimethoxybenzene, m-dimethoxybenzene, and p-dimethoxybenzene, whereas F-TEDA-BF₄ as a mediator/oxidizer could be replaced by hydrogen peroxide in the case of the functionalization of 1-(4-methoxyphenyl)ethanone, o-dimethoxybenzene, m-dimethoxybenzene, and p-dimethoxybenzene. Water changes the type of transformation of p-methoxybenzyl alc. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Computed Properties of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Computed Properties of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Radioiodination and astatination of octreotide by conjugation labeling was written by Vaidyanathan, G.;Affleck, D.;Welsh, P.;Srinivasan, A.;Schmidt, M.;Zalutsky, M. R.. And the article was included in Nuclear Medicine and Biology in 2000.Category: iodides-buliding-blocks This article mentions the following:

Octreotide was coupled to 3-iodobenzoyl and 3-iodonicotinoyl moieties to obtain [N-(3-iodobenzoyl)-d-Phe¹]octreotide (IBO) and [N-(3-iodonicotinoyl)-d-Phe¹]octreotide (INO), resp. The IC₅₀ values for the binding of IBO and INO to CA20948 rat pancreatic tumor membranes were 0.90 and 0.13 nM, resp., compared with 0.35 nM for octreotide itself. Starting from N-succinimidyl 3-[¹³¹I]iodobenzoate and N-succinimidyl 5-[¹³¹I]iodopyridine-3- carboxylate, [¹³¹I]IBO and [¹³¹I]INO were prepared in overall radiochem. yields of 35%-50%. Likewise, {N-(3-[²¹¹At]astatobenzoyl)-d-Phe¹}octreotide ([²¹¹At]ABO) was prepared in similar yield from N-succinimidyl 3-[²¹¹At]astatobenzoate. In vitro assays with AR42J rat pancreatic tumor cells demonstrated a higher retention of cell-internalized radioiodine activity for [¹³¹I]INO compared with [¹²⁵I]IBO. Tissue distribution studies with both conjugates revealed low levels of activity in the thyroid suggesting that dehalogenation of these peptides was minimal. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Category: iodides-buliding-blocks).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters was written by Banik, Steven M.;Medley, Jonathan William;Jacobsen, Eric N.. And the article was included in Science (Washington, DC, United States) in 2016.Synthetic Route of C8H7IO4 This article mentions the following:

Difluoromethyl groups possess specific steric and electronic properties that invite their use as chem. inert surrogates of alcs., thiols, and other polar functional groups important in a wide assortment of mol. recognition processes. We report here a method for the catalytic, asym., migratory geminal difluorination of β-substituted styrenes to access a variety of products bearing difluoromethylated tertiary or quaternary stereocenters. The reaction uses com. available reagents (m-chloroperbenzoic acid and hydrogen fluoride pyridine) and a simple chiral aryl iodide catalyst and is carried out readily on a gram scale. Substituent effects and temperature-dependent variations in enantioselectivity suggest that cation-π interactions play an important role in stereodifferentiation by the catalyst. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Synthetic Route of C8H7IO4).

Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C8H7IO4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com