Tag: 200-300

In 2022,Sun, Bozheng; Oakley, Meagan S.; Yoshida, Kota; Yang, Yanwen; Tommasini, Matteo; Zanchi, Chiara; Lucotti, Andrea; Ferguson, Michael J.; Hampel, Frank; Klobukowski, Mariusz; Tykwinski, Rik R. published an article in Chemistry – A European Journal. The title of the article was 《The Effects of Ring Strain on Cyclic Tetraaryl[5]cumulenes》.Reference of 1-Bromo-3-iodobenzene The author mentioned the following in the article:

Cyclic tetraaryl[5]cumulenes I (n = 1, 2, 3, 4, 5, 6) have been synthesized and studied as a function of increasing ring strain. The magnitude of ring strain is approximated by the extent of bending of the cumulenic core as assessed by a combination of X-ray crystallog. anal. and DFT calculations In particular, the exptl. HOMO-LUMO gap is not appreciably affected by bending of the [5]cumulene framework from ca. 174°λmax = 504 nm in I (n = 1) to ca. 178° λmax = 494 nm in I (n = 6). In addition to this study using 1-Bromo-3-iodobenzene, there are many other studies that have used 1-Bromo-3-iodobenzene(cas: 591-18-4Reference of 1-Bromo-3-iodobenzene) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Reference of 1-Bromo-3-iodobenzene Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Yunting; Wang, Zihan; Guo, Na; Liu, Pengbo; Liu, Guanhua; Gao, Jing; Zhang, Lei; Jiang, Yanjun published an article in 2021. The article was titled 《Polydopamine-Encapsulated Dendritic Organosilica Nanoparticles as Amphiphilic Platforms for Highly Efficient Heterogeneous Catalysis in Water》, and you may find the article in Chinese Journal of Chemistry.Product Details of 15854-87-2 The information in the text is summarized as follows:

Herein, a type of amphiphilic core-shell catalysts with a hydrophilic polydopamine (PDA) shell and a hydrophobic dendritic organosilica nanoparticle (DON) core for heterogeneous catalysis in water was synthesized. The hydrophilic shell allowed the catalyst dispersing well in water, and the hydrophobic core facilitated the absorption of organic reactants. The hierarchical core-shell structure facilitated rational arrangement of the location of catalytic species to match the reaction sequence. The obtained metal, enzyme and metal-enzyme amphiphilic catalysts demonstrated improved stability, selectivity and activity in aqueous reactions, including Pd-catalyzed cross-couplings (Suzuki, Liebeskind-Srogl, Heck and Sonogashira), enzymic enantioselective reduction, chemoenzymic cascade synthesis of chiral compounds and chemoenzymic cascade degradation of organophosphates. The amphiphilic catalysts were easily recovered and their high catalytic performance was sustained for five cycles.4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis of antisense oligonucleotides containing acyclic alkynyl nucleoside analogs and their biophysical and biological properties》 was written by Ogata, Aya; Maeda, Yusuke; Ueno, Yoshihito. Application In Synthesis of 2-Amino-5-iodopyrimidin-4(1H)-one And the article was included in Bioorganic & Medicinal Chemistry on April 1 ,2017. The article conveys some information:

The synthesis of oligonucleotide (ON) analogs, which can be used as antisense mols., has recently gained much attention. Here, we report the synthesis and properties of an ON analog containing acyclic thymidine and cytidine analogs with a 4-pentyl-1,2-diol instead of the D-ribofuranose moiety. The incorporation of these analogs into the ON improved its nuclease resistance to 3′-exonucleases. Furthermore, it was found that the incorporation of the acyclic thymidine analog into a DNA/RNA duplex accelerates the RNA cleavage of a DNA/RNA duplex by Escherichia coli RNase H. In the part of experimental materials, we found many familiar compounds, such as 2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1Application In Synthesis of 2-Amino-5-iodopyrimidin-4(1H)-one)

2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Application In Synthesis of 2-Amino-5-iodopyrimidin-4(1H)-one

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 4-IodopyridineIn 2022 ,《Synthesis and Mechanistic Investigation of Bipyrazolo[1,5-a]pyridines via Palladium-Catalyzed Cross-Dehydrogenative Coupling of Pyrazolo[1,5-a]pyridines》 appeared in Journal of Organic Chemistry. The author of the article were Hsiao, Pu-Yen; Chang, Rong; Sue, Andrew C.-H.; Chu, Jean-Ho; Liao, Guan-Wei; Lee, Yi-Hsin; Huang, Jui-Yang. The article conveys some information:

The synthesis of a range of 3,3′-bipyrazolo[1,5-a]pyridine derivatives via direct cross-dehydrogenative coupling of pyrazolo[1,5-a]pyridine precursors was herein presented. This simple and efficient methodol. involving palladium(II)-catalyzed C-H bond activation showed good functional group tolerance and product yield (up to 94%). Through the mechanistic insights gained from both kinetic isotope effect exptl. studies and d. functional theory calculations, a plausible reaction mechanism was outlined. Furthermore, subsequent derivatizations of the resulting 7,7′-diaryl-3,3′-bipyrazolo[1,5-a]pyridines, executed by performing palladium-mediated ortho C-H bond activation followed by hypervalent iodine-induced chlorination, rendered this series of compounds more extended π-conjugation and twisted conformations. The study on these bipyrazolo[1,5-a]pyridine-based luminogens provided new opportunities for tailor-made organic luminescent materials.4-Iodopyridine(cas: 15854-87-2Recommanded Product: 4-Iodopyridine) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Recommanded Product: 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of 1,2-DiiodoethaneIn 2021 ,《Cooperative Catalysis of Ru(III)-Porphyrin in CO2-Involved Synthesis of Oxazolidinones》 appeared in Chemistry – An Asian Journal. The author of the article were Chen, Xiao-Chao; Yao, Yin-Qing; Zhao, Kai-Chun; Liu, Lei; Lu, Yong; Liu, Ye. The article conveys some information:

Herein, a Ru(III)-porphyrin catalyst (RuCl3·3H2O-H2TPP) was found highly efficient in the three-component reaction of CO2, aliphatic amines and dichloroethane (or its derivative) for synthesis of oxazolidinones in the yields of 71∼91%. It was indicated by means of the control experiments and UV-vis spectra that CO2 was stoichiometrically activated by the involved aliphatic amine substrates to form a stable carbamate salt while 1,2-dichloroethane (or its derivative) was independently activated by the involved Ru(III)-porphyrin catalyst. The combination of CO2-activation by aliphatic amines with 1,2-dichloroethane activation by Ru(III)-porphyrin catalyst cooperatively contributed to this successful transformation. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Quality Control of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Quality Control of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wang, Can; Xiong, Qiu; Zhang, Zilong; Meng, Lingyi; Li, Feng; Yang, Longkai; Wang, Xiaobing; Zhou, Qin; Fan, Weihang; Liang, Lusheng; Lien, Shui-Yang; Li, Xin; Wu, Jihuai; Gao, Peng published an article in ACS Applied Materials & Interfaces. The title of the article was 《Deciphering the reduced loss in high fill factor inverted perovskite solar cells with methoxy-substituted poly(triarylamine) as the hole selective contact》.COA of Formula: C6H4BrI The author mentioned the following in the article:

A dopant-free polymeric hole selective contact (HSC) layer is ubiquitous for stable perovskite solar cells (PSCs). However, the intrinsic nonwetting nature of the polymeric HSC impedes the uniform spreading of the perovskite precursor solution, generating a terrible buried interface. Here, we dexterously tackle this dilemma from the perspective of dispersive and polar component surface energies of the HSC layer. A novel triarylamine-based HSC material, poly[bis(4-phenyl)(2,4-dimethoxyphenyl)amine] (2MeO-PTAA), was designed by introducing the polar methoxy groups to the para and ortho positions of the dangling benzene. These nonsym. substituted electron-donating methoxy groups enhanced the polar components of surface energy, allowing more tight interfacial contact between the HSC layer and perovskite and facilitating hole extraction When utilized as the dopant-free HSC layer in inverted PSCs, the 2MeO-PTAA-based device with CH3NH3PbI3 as the absorber exhibited an encouraging power conversion efficiency of 20.23% and a high fill factor of 84.31% with negligible hysteresis. Finally, a revised detailed balance model was used to verify the drastically lessened surface defect-induced recombination loss and shunt resistance loss in 2MeO-PTAA-based devices. This work demonstrates a facile and efficient way to modulate the buried interface and shed light on the direction to further improve the photovoltaic performance of inverted PSCs with other types of perovskites. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-iodobenzene(cas: 589-87-7COA of Formula: C6H4BrI)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..COA of Formula: C6H4BrI It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koteswaraiah, M.; Praveen, Ch; reddy, Thummaluru Veera; Raveendrareddy, Gopireddy; Srinivas, Uppalanchi published an article in 2022. The article was titled 《Design, synthesis and biological evaluation of aryl and hetero-aryl linked thieno[3,2-d]pyrimidine derivatives as anticancer agents》, and you may find the article in Chemical Data Collections.COA of Formula: C5H4IN The information in the text is summarized as follows:

A new library of different aryl and heteroaryl linked thieno[3,2-d]pyrimidine derivatives I [Ar = 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, etc.] were synthesized and characterized by 1HNMR, 13CNMR and mass spectroscopic techniques. Further, these were evaluated for their anticancer potentials against the selected four human cancer cell lines including PC3 (prostate cancer), A549 (lung cancer), MCF-7 (breast cancer) and DU-145 (prostate cancer). The obtained results suggested that four compounds I [Ar = 3,4,5-tri-MeOC6H2, 3,5-di-MeOC6H3, 4-pyridyl, 4-pyrazyl] exhibited more potent anticancer properties. Predominantly, two compounds I [Ar = 3,4,5-tri-MeOC6H2, 4-pyridyl] demonstrated most capable anticancer activity of the library. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2COA of Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.COA of Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shen, Yifeng; Xu, Congjun; Chen, Jie; Guan, Zilin; Huang, Yanjuan; Zeng, Zishan; Xu, Xiaoyu; Tan, Xiaomin; Zhao, Chunshun published an article in 2021. The article was titled 《Phototriggered Self-Adaptive Functionalized MOC-Based Drug Delivery Platform Promises High Antitumor Efficacy》, and you may find the article in Advanced Healthcare Materials.HPLC of Formula: 15854-87-2 The information in the text is summarized as follows:

Due to their great stability and special cavities, metal-organic cages (MOCs) are increasingly considered as promising nanocarriers for drug delivery. However, the size and surface dilemmas restrict their further biomedical applications. The ultrasmall size of MOCs facilitates tumor penetration but suffers from quick clearance and poor accumulation at the tumor site. Hydrophobicity of MOC surfaces improves internalization into tumor cells while causing low blood circulation time as well as poor biocompatibility. Therefore, it remains challenging for the MOC-based drug delivery nanoplatform to realize high therapeutic efficacy because it requires different or even opposite dimensions and surface characteristics in different steps of circulation, penetration, accumulation, and internalization processes. In this study, an unprecedented phototriggered self-adaptive platform (ZnPc@polySCage) is developed by integrating functionalized MOCs and a photodynamic therapy based reactive oxygen species responsive strategy to realize high-efficiency tumor-specific therapy. ZnPc@polySCage remains hydrophilic and stealthy during circulation, and retains its small original size for tumor penetration, while transforming to a larger size for effective accumulation and hydrophobic for enhanced internalization under laser irradiation in tumor tissue. With these essential transitions, ZnPc@polySCage demonstrates prominent antitumor effects. Overall, the work provides an advantageous strategy for functional MOC-based platforms and biomedical applications. In addition to this study using 4-Iodopyridine, there are many other studies that have used 4-Iodopyridine(cas: 15854-87-2HPLC of Formula: 15854-87-2) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.HPLC of Formula: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Yunsheng; Yang, Jie; Fang, Manman; Gong, Yanxiang; Ren, Jia; Tu, Liangjing; Tang, Ben Zhong; Li, Zhen published an article in 2021. The article was titled 《New Phenothiazine Derivatives That Exhibit Photoinduced Room-Temperature Phosphorescence》, and you may find the article in Advanced Functional Materials.Electric Literature of C6H4BrI The information in the text is summarized as follows:

The research of purely organic room-temperature phosphorescence (RTP) materials with stimulus response characteristic has drawn increasing attention for their broad application prospects. However, these kinds of materials are really scarce now, especially for those with efficient RTP emissions, which have largely limited their practical applications. Here, an all-around-type player in the field of photoinduced phosphorescence material appears, whose RTP efficiency can increase from near 0 to 22% after continuous UV irradiation Correspondingly, the UV-written patterns based on them can be clearly observed by the naked eye in daytime or even under sunlight. Moreover, these materials are found to show excellent photostability, and the strong RTP emission can still be observed after repeated activation for more than 50 times. The high RTP efficiency and good photostability make these photoinduced RTP materials exhibit an attractive prospect for potential applications in many fields, including leak test, microcrack detection, programmable information storage, and encryption. After reading the article, we found that the author used 1-Bromo-4-iodobenzene(cas: 589-87-7Electric Literature of C6H4BrI)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..Electric Literature of C6H4BrI It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Du, Yijun; Gou, Faliang; Gao, Danning; Liu, Zhifeng; Shao, Linjun; Qi, Chenze published an article in 2021. The article was titled 《Palladium nanoparticles encapsulated in polyimide nanofibers: An efficient and recyclable catalyst for coupling reaction》, and you may find the article in Applied Organometallic Chemistry.Related Products of 15854-87-2 The information in the text is summarized as follows:

In this study, palladium-encapsulated poly(amic acid) (Pd@PAA) nanofibers were prepared by electrospinning, followed by thermal imidization to synthesize palladium-encapsulated polyimide (Pd@PI) nanofibers. SEM images confirmed the preparation of uniform and smooth Pd@PAA and Pd@PI nanofibers. Thermogravimetric anal. (TGA) results reveal that the Pd@PI nanofibers possessed excellent thermal stability. The dispersion of palladium nanoparticles in the polyimide nanofibers was characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The catalysis results show that this Pd@PI fibrous catalyst was very efficient to catalyze the cross-coupling reactions of aromatic iodides with Bu acrylate (Heck reaction) or phenylboronic acid derivatives (Suzuki reaction) to afford the desired products in good to excellent yields. Moreover, the Pd@PI catalyst could be easily separated and recovered from the reaction mixture by simple filtration due to the regular fibrous structure and reused for 10 times for both Heck and Suzuki reactions without obvious loss of its initial catalytic activity. Thus, the Pd@PI nanofiber catalyst holds great potential in chem. industry in terms of its excellent catalytic activity and stability. In the experiment, the researchers used 4-Iodopyridine(cas: 15854-87-2Related Products of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Related Products of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com