Tag: 200-300

In 2022,Musza, Katalin; Meszaros, Rebeka; Baan, Kornelia; Konya, Zoltan; Kukovecz, Akos; Palinko, Istvan; Sipos, Pal; Szabados, Marton published an article in Journal of Molecular Structure. The title of the article was 《Mechanochemical preparation of NiCuSn nanoparticles and composites in presence of cetyltrimethylammonium bromide (CTAB) and the catalytic application of the products in homocoupling and hydration of terminal alkynes》.Related Products of 516-12-1 The author mentioned the following in the article:

The synthesis of the NiCuSn nanoparticles and nanocomposites in mechanochem. route using CTAB as milling additive was reported. The study of grinding intensity (frequency) and time interval drew up the importance of the well-chosen operation parameters. The mild milling resulted in formation of NiSn intermetallics, while the intense ones aided the evolution of bronze and copper(I) oxide phases. The utilization of CTAB proved to be the key factor to prevent or slow down the process of mech. alloying and to fritter the metal grains into the nanodimensions. The dynamic light scattering data demonstrated pos. charged particles with average solvodynamic diameters of around 70 nm applying intense or long-term millings. Without CTAB or with relatively short or weak grindings, these values remained between 230 and 550 nm, as in the case of the surface areas getting around 20 m2/g with and 1 m2/g without CTAB. The catalytic transformation of p-methoxyphenylacetylene in DMSO showed that the copper, copper(I) oxide and bronze particles managed the reaction toward the evolution of 1,3-diyne in Glaser-Hay homocoupling without base addition, while the Sn and SnO2 phases assisted to the Markovnikov-type hydration of alkyne groups. The formation of α-diketone signed that the anti-Markovnikov route was also occurred. The use of CTAB was found to exert a profound effect on the quality of catalytic end-products through the controlled generation of bronze and tin oxide phases and the solid solution of nickel atoms. In the part of experimental materials, we found many familiar compounds, such as 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Related Products of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Related Products of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Mahesh Kumar, Avula; Venkateshwarlu, Rapolu; Tadiparthi, Krishnaji; Rao, B. Venkateswara; Kota Balaji, Shiva Kumar; Raghunadh, Akula; Singh, Shambhu Nath published an article in Synthetic Communications. The title of the article was 《A new facile synthesis of (2S,5S)-5-hydroxypipecolic acid hydrochloride》.Product Details of 1774-47-6 The author mentioned the following in the article:

A simple and efficient synthesis of (2S,5S)-5-Hydroxypipecolic acid hydrochloride was reported. The key features of the synthesis involve the asym. reduction of ketone using (S)-CBS oxazaborolidine and the use of com. available Me pyroglutamate as a starting material. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Product Details of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Product Details of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Galea, Romeric; Blond, Gaelle published an article in Advanced Synthesis & Catalysis. The title of the article was 《Gold(I)-Catalyzed Domino Reaction: An Access to Furooxepines》.Computed Properties of C6H4BrI The author mentioned the following in the article:

The synthesis of [7,5]-fused bicyclic acetals, also named furooxepines I (Ar = 4-chloro-3-fluorophenyl, thiophen-2-yl, naphthalen-2-yl, etc.) through a gold(I)-catalyzed domino reaction was reported. During this transformation, two mols. of homopropargyl alc. ArCC(CH2)2OH react together, in a sequence including intramol. hydroalkoxylation, condensation, 1,6-enyne cycloisomerization, acetalization and isomerization. This gold(I)-catalyzed domino reaction allows the formation of three bonds, two heterocycles and tetrasubstituted carbon stereocenters in a one-step operation with 100% atom economy. Post-functionalizations allow the formation of tetrahydrofurans. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-iodobenzene(cas: 591-18-4Computed Properties of C6H4BrI)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Computed Properties of C6H4BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Yang, Xiaogang; Lu, Dong; Guan, Wenjian; Yin, Shuang-Feng; Kambe, Nobuaki; Qiu, Renhua published an article in Journal of Organic Chemistry. The title of the article was 《Synthesis of (Deoxy)difluoromethylated Phosphines by Reaction of R2P(O)H with TMSCF3 and Their Application in Cu(I) Clusters in Sonogashira Coupling》.Reference of 4-Iodobenzaldehyde The author mentioned the following in the article:

R2PCF2H ligands and their R2P(O)CF2H precursors were synthesized from R2P(O)H with TMSCF3 by simply modulating the H2O concentration via deoxydifluoromethylation and difluoromethylation. The air sensitive R2PCF2H phosphines can be stabilized in Cu(I) clusters as ligands. Within these Cu(I) clusters, the Sonogashira cross-coupling reaction can proceed fast and efficiently using terminal alkynes and aryl iodides within 15 min at room temperature under air to give a variety of diaryl(alkyl)acetylenes in good yields (49 examples, yields of ≤99%). Six of the internal alkynes present in drug precursors can be obtained using this protocol in good yields. The mechanism is proposed from control experiments The experimental process involved the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Reference of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Reference of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bai, Guoyun; O’Connell, Thomas N.; Brodney, Michael A.; Butler, Christopher R.; Czabaniuk, Lara C.; Gilbert, Adam M.; LaChapelle, Erik A.; Li, Chao; McAllister, Laura A.; Ogilvie, Kevin; Philippe, Laurence; Salomon-Ferrer, Romelia; Shapiro, Michael J.; Starr, Jeremy T.; Uccello, Daniel P.; Withka, Jane M.; Yan, Jiangli; Brown, Matthew F. published an article in 2021. The article was titled 《Intramolecular Ring-Opening Decomposition of Aryl Azetidines》, and you may find the article in ACS Medicinal Chemistry Letters.Safety of 4-Iodopyridine The information in the text is summarized as follows:

The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramol. ring-opening decomposition via nucleophilic attack of a pendant amide group. Studies were conducted to understand the decomposition mechanism enabling the design of stable analogs. In addition to this study using 4-Iodopyridine, there are many other studies that have used 4-Iodopyridine(cas: 15854-87-2Safety of 4-Iodopyridine) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Safety of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Thanetchaiyakup, Adisak; Borwornpinyo, Suparerk; Rattanarat, Hassayaporn; Kanjanasirirat, Phongthon; Jearawuttanakul, Kedchin; Seemakhan, Sawinee; Chuanopparat, Nutthawat; Ngernmeesri, Paiboon published an article in 2021. The article was titled 《Copper-catalyzed synthesis and anticancer activity evaluation of indolo[1,2-a]quinoline derivatives》, and you may find the article in Tetrahedron Letters.Application of 15164-44-0 The information in the text is summarized as follows:

A simple and effective one-pot synthesis of substituted indolo[1,2-a]quinolines I (R = CHO, CN; R1 = H, Me, Cl, F, etc.; R2 = H, Me, Ph) has been developed. The desired products I were obtained in up to 98% yield when substituted 2-methyindoles II were treated with 2-iodobenzaldehyde in the presence of Cs2CO3, CuI and L-proline. The mechanistic study confirmed that the reaction sequence involved an intermol. Knoevenagel reaction followed by an intramol. Ullmann-type coupling reaction. Moreover, some of the synthesized compounds I were found to be active against human breast (MCF-7) and colorectal (HCT-116) cancer cells with IC50 values of 27.96μM and in the range of 6.21-46.91μM, resp. In the experimental materials used by the author, we found 4-Iodobenzaldehyde(cas: 15164-44-0Application of 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Application of 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Manisha; Gupta, Shiv Shankar; Dhiman, Ankit Kumar; Sharma, Upendra published an article in 2021. The article was titled 《Rh(III)-Catalyzed Selective C7 Halogenation of Indolines》, and you may find the article in European Journal of Organic Chemistry.Application In Synthesis of 1-Iodopyrrolidine-2,5-dione The information in the text is summarized as follows:

An efficient Rh-catalyzed catalytic method has been developed for selective C7 halogenation of N-pyrimidyl indolines I (R = H, 5-Ph, 6-F, OCH2Ph, etc., R1 = H, 2-EtO2C, 3-Me, 2-Me, R2 = H) with N-halosuccinimides (halo = chloro, bromo, iodo) to produce the corresponding halides I (R2 = Br, Cl, I) in good to excellent yields. The advantages of this strategy include broad substrate scope and excellent regioselectivity for C7 functionalization of the indolines and feasibility at the gram scale level. Various control experiments have been performed to understand the reaction pathway. Applicability of current methodol. has been demonstrated by indole synthesis and post-transformation of the C7 halogenated indolines into different valuable mols. The reaction is also applicable to the preparation of halogenated carbazoles II (R2 = Br, Cl, I) and tetrahydroquinolines III (R2 = Br, I). In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Application In Synthesis of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Application In Synthesis of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fang, Mao-Ying; Chen, Li-Ping; Huang, Lin; Fang, Dong-Mei; Chen, Xiao-Zhen; Wang, Bi-Qin; Feng, Chun; Xiang, Shi-Kai published an article in 2021. The article was titled 《Synthesis of Tribenzo[b,d,f]azepines via Palladium-Catalyzed Annulation Reaction of 2-Iodobiphenyls with 2-Halogenoanilines》, and you may find the article in Journal of Organic Chemistry.Product Details of 63069-48-7 The information in the text is summarized as follows:

A palladium-catalyzed annulation reaction of 2-iodobiphenyls with 2-halogenoanilines has been developed. A variety of 2-iodobiphenyls and 2-halogenoanilines can undergo this transformation. Diversified tribenzo[b,d,f]azepine derivatives can be synthesized in moderate to excellent yields according to this method.4-Chloro-2-iodoaniline(cas: 63069-48-7Product Details of 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Product Details of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Escopy, Samira; Singh, Yashapal; Stine, Keith J.; Demchenko, Alexei V. published their research in Chemistry – A European Journal in 2021. The article was titled 《A Streamlined Regenerative Glycosylation Reaction: Direct, Acid-Free Activation of Thioglycosides》.Synthetic Route of C4H4INO2 The article contains the following contents:

Our group has previously reported that 3,3-difluoroxindole (HOFox) is able to mediate glycosylation via intermediacy of OFox imidates. Thioglycoside precursors were first converted into the corresponding glycosyl bromides that were then converted into the OFox imidates in the presence of Ag2O followed by the activation with catalytic Lewis acid in a regenerative fashion. Reported herein is a direct conversion of thioglycosides via the regenerative approach that bypasses the intermediacy of bromides and eliminates the need for heavy-metal-based promoters. The direct regenerative activation of thioglycosides is achieved under neutral reaction conditions using only 1 equivalent NIS and catalytic HOFox without the acidic additives. In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Synthetic Route of C4H4INO2)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Synthetic Route of C4H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Qian; Gong, Haiying; Zhang, Yifang; Peng, Yi; Chen, Hua; Li, Mingjie; Deng, Hongmei; Hao, Jian; Wan, Wen published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Visible-light mediated stereospecific C(sp2)-H difluoroalkylation of (Z)-aldoximes》.COA of Formula: C7H5IO The article contains the following contents:

A visible light mediated stereospecific C(sp2)-H difluoroalkylation of (Z)-aldoximes to (E)-difluoroalkylated ketoximes was described. In this reaction, (hetero)-aromatic and aliphatic difluoroalkylated ketoximes could be obtained with the retention of the configuration of the starting aldoximes. A preliminary mechanism study showed that a difluoromethyl radical via an SET pathway was involved. After reading the article, we found that the author used 4-Iodobenzaldehyde(cas: 15164-44-0COA of Formula: C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.COA of Formula: C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com