Tag: 200-300

In 2019,Chemistry – A European Journal included an article by Virelli, Matteo; Wang, Wei; Kuniyil, Rositha; Wu, Jun; Zanoni, Giuseppe; Fernandez, Antonio; Scott, Jamie; Vendrell, Marc; Ackermann, Lutz. Category: iodides-buliding-blocks. The article was titled 《BODIPY-Labeled Cyclobutanes by Secondary C(sp3)-H Arylations for Live-Cell Imaging》. The information in the text is summarized as follows:

Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3)-H activation, exploiting chelation assistance by modular triazoles. The C-H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the easy access to novel fluorogenic boron-dipyrrin (BODIPY)-labeled probes for live-cell imaging.1-Chloro-3-iodobenzene(cas: 625-99-0Category: iodides-buliding-blocks) was used in this study.

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Category: iodides-buliding-blocks Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Macromolecular Chemistry and Physics included an article by Cao, Yakun; Kumar, Rajesh; Tsarevsky, Nicolay V.. Product Details of 88-67-5. The article was titled 《Employing Heterocyclic Hypervalent Iodine Compounds with I-Cl Bonds as Initiators and Chain Transfer Agents in the Synthesis of Branched Polymers》. The information in the text is summarized as follows:

Heterocyclic hypervalent (HV) I(III) compounds with I-Cl bonds and various substituents at the N atom are synthesized and are very efficient chain transfer agents in the polymerization of styrene with transfer coefficients exceeding that of CCl4 by 2-3 orders of magnitude, depending on the structure. The chain transfer rate coefficients are also determined Due to the presence of thermally labile HV bonds, the compounds degrade homolytically upon heating and can initiate radical polymerization For instance, 1-chloro-2-hexyl-1,2-benziodazol-3(2H)-one, is used in the polymerization of styrene, which yields low mol. weight polymers with alkyl chloride groups at the α- (initiation) and the ω-chain ends (transfer). Chain-end functionalization reactions with azide and chain extension under low-catalyst-concentration atom transfer radical polymerization (ATRP) conditions of the prepared telechelic polymers are carried out. The same initiator/chain transfer agent is successfully employed in the synthesis of highly branched polymers with multiple alkyl chloride-type chain ends when added to mixtures of styrene and 1,4-divinylbenzene containing 10-80 mol% of the divinyl crosslinker, or even pure crosslinker. In all cases, soluble hyperbranched polymers are obtained up to moderate monomer conversions. The effects of crosslinker and HV I(III) compound concentrations on the polymerization outcome are studied systematically. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5Product Details of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Product Details of 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Advanced Synthesis & Catalysis included an article by Dey, Raghunath; Banerjee, Prabal. Product Details of 1774-47-6. The article was titled 《Metal-Free Ring Opening Cyclization of Cyclopropane Carbaldehydes and N-Benzyl Anilines: An Eco-Friendly Access to Functionalized Benzo[b]azepine Derivatives》. The information in the text is summarized as follows:

In the presence of 0.2 equivalent or 1.2 equivalent of p-TsOH, arylcyclopropanecarboxaldehydes such as I and a bicycloheptanecarboxaldehyde underwent ring opening or tandem ring opening and cyclocondensation reactions with N-benzylic anilines such as II at ambient temperature in CH2Cl2 to yield either γ-aryl-γ-(arylamino)butanals such as III and arylbenzazepines such as IV, resp. IV was reduced to the corresponding tetrahydrobenzazepine. In the experimental materials used by the author, we found Trimethylsulfoxonium iodide(cas: 1774-47-6Product Details of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Product Details of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,European Journal of Organic Chemistry included an article by Luo, Yi; Guo, Lingmei; Yu, Xinling; Ding, Haosheng; Wang, Huijing; Wu, Yong. Application of 1774-47-6. The article was titled 《Cp*IrIII-Catalyzed [3+2] Annulations of N-Aryl-2-aminopyrimidines with Sulfoxonium Ylides to Access 2-Alkyl Indoles Through C-H Bond Activation》. The information in the text is summarized as follows:

The iridium-catalyzed aromatic C-H alkylation followed by intramol. annulation reactions between N-aryl-2-aminopyridines and sulfoxonium ylides for the synthesis of 2-alkyl indoles is described. This highly efficient and step-economical cyclization reaction displays excellent functional group compatibility and regioselectivity. Afterwards, the directing group in C-H alkylation can be readily removed to obtain the free N-H indoles. Thus, the sulfoxonium ylide, a carbene precursor, is proved as a useful surrogate of diazo compounds in C-H activation chem. In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Application of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Application of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis of new heterocyclic basic derivatives of expected amebicidal activity》 were Abu-Zeid, Y. M.; Abu-Elela, Z.; Ghoneim, K. M.. And the article was published in J. Pharm. Sci. U. Arab. Rep. in 1965. SDS of cas: 3993-79-1 The author mentioned the following in the article:

Halogenated derivatives of the heterocyclic nuclei pyridine, quinoline (I), and pyrimidine (II) were prepared Sulfonation of 8-Cl-I with 6 parts 20% fuming H2SO4 gave the 5-sulfonic acid (III). All trials to brominate or iodinate III and its Na salt or Me ester failed: non-aqueous media, different temperatures with variable duration, and 48% HBr with Br in CH3COOH. Also sulfonation of 5-Br-8-Cl-I was not successful. The II derivatives prepared were: 2-NH2-4-OH-II, 2-NH2-4-Cl-II, 2-NH2-4-OH-II-5-sulfonic acid, and the 2 new compounds 2-NH2-5-iodo-4-OH-II (IV), and 2-NH2-4-Cl-5-iodo II (V). IV was prepared by refluxing mercuric acetate, isocytosine (modified method of Roblin, et al., CA 36, 25329), and iodine in dioxane at 70° for 2 hrs. The precipitate resulting on addition to 15% KI solution was washed and crystallized from CH3COOH; yield 89.6%. V was prepared by refluxing gently POCl3, dimethylaniline, and 5-iodoisocytosine for 3 hrs. On alkalinization with NH4OH, boiling, filtration, and concentration V separated on cooling; yield 48%. In addition to this study using 2-Amino-5-iodopyrimidin-4(1H)-one, there are many other studies that have used 2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1SDS of cas: 3993-79-1) was used in this study.

2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.SDS of cas: 3993-79-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis of 6-benzylimidazo[2,1-b][1,3]thiazole during Sonogashira coupling》 were Bakherad, Mohammad; Keivanloo, Ali; Tajbakhsh, Mahmood; Kamali, Taghi A.. And the article was published in Synthetic Communications in 2010. SDS of cas: 41252-95-3 The author mentioned the following in the article:

The reaction of 2-amino-3-(2-propynyl)-1,3-thiazolium bromide with various iodobenzenes in the presence of palladium catalyst led to the formation of 6-benzylimidazo[2,1-b][1,3]thiazoles.1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3SDS of cas: 41252-95-3) was used in this study.

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.SDS of cas: 41252-95-3Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Product Details of 161489-05-0On March 10, 1995, Boucher, Eric; Simard, Michel; Wuest, James D. published an article in Journal of Organic Chemistry. The article was 《Use of Hydrogen Bonds to Control Molecular Aggregation. Behavior of Dipyridones and Pyridone-Pyrimidones Designed To Form Cyclic Triplexes》. The article mentions the following:

The tendency of 2-pyridones and related heterocycles to form cyclic hydrogen-bonded dimers allows them to be used as sticky sites that induce mols. in which they are incorporated to associate in particular ways. I, which is constructed from pyridone and pyrimidone subunits linked to a rigid linear acetylenic spacer, incorporates an array of hydrogen-bonding sites designed to favor the formation of a cyclic triplex. I was prepared and the structure of its DMSO solvate was determined by X-ray crystallog. Aggregation does not produce a cyclic triplex but rather gives chains in which adjacent mols. of I are linked by single hydrogen bonds. After reading the article, we found that the author used 4-Iodo-6-methoxypyrimidine(cas: 161489-05-0Product Details of 161489-05-0)

4-Iodo-6-methoxypyrimidine(cas: 161489-05-0) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Product Details of 161489-05-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Pd-Cu-mediated synthesis of 2-substituted imidazo[1,2-α]pyridines in water》 was published in Synthetic Communications in 2009. These research results belong to Bakherad, Mohammad; Keivanloo, Ali; Hashemi, Mahdieh. Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene The article mentions the following:

The reaction of 2-amino-1-(2-propynyl)pyridinium bromide with various iodobenzenes, catalyzed by Pd-Cu, in the presence of sodium lauryl sulfate as the surfactant and cesium carbonate as the base, in water, led to the formation of 2-substituted imidazo[1,2-α]pyridines. After reading the article, we found that the author used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Formula: C7H5IO2In 2022 ,《Synthesis, characterization and anti-microbial screening of novel substituted thiadiazole-5-aminotetrazoles》 was published in Chemistry & Biology Interface. The article was written by Gaikwad, Mahadev; Gorepatil, Amarsinha; Gorepatil, Pratapsinha; Kadam, Vishal; Gaikwad, Shivshankar; Shinde, Vishnu; Ingle, Vilas. The article contains the following contents:

An efficient and green synthesis of substituted thiadiazole-5-aminotetrazoles I [R = Ph, benzyl, cinnamyl, etc.] were prepared in-situ by reaction of cyanogen bromide and sodium azide to generate a cyanogen azide as an intermediate in acetonitrile. The cyclization reaction of cyanogen azide and substituted thiadiazoles containing primary amines in acetonitrile-water solvent media, gave the intermediate 1-substituted 5-aminotetrazoles in good yield. In addition, to further evaluate the role of synthesized mols. for antimicrobial activities, and it’s found that compound I [R = 4-O2NC6H4, 2-IC6H4] showed a good antimicrobial for broad range of bacterial and fungal pathogens. After reading the article, we found that the author used 2-Iodobenzoic acid(cas: 88-67-5Formula: C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C7H5IO2 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2021 ,《Selective Modification for Red-Shifted Excitability: A Small Change in Structure, a Huge Change in Photochemistry》 was published in Chemistry – A European Journal. The article was written by Becker, Yvonne; Roth, Sina; Scheurer, Maximilian; Jakob, Andreas; Gacek, Daniel A.; Walla, Peter J.; Dreuw, Andreas; Wachtveitl, Josef; Heckel, Alexander. The article contains the following contents:

We developed three bathochromic, green-light activatable, photolabile protecting groups based on a nitrodibenzofuran (NDBF) core with D-π-A push-pull structures. Variation of donor substituents (D) at the favored ring position enabled us to observe their impact on the photolysis quantum yields. Comparing our new azetidinyl-NDBF (Az-NDBF) photolabile protecting group with our earlier published DMA-NDBF, we obtained insight into its excitation-specific photochem. While the “”two-photon-only”” cage DMA-NDBF was inert against one-photon excitation (1PE) in the visible spectral range, we were able to efficiently release glutamic acid from azetidinyl-NDBF with irradiation at 420 and 530 nm. Thus, a minimal change (a cyclization adding only one carbon atom) resulted in a drastically changed photochem. behavior, which enables photolysis in the green part of the spectrum. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocksIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com