Tag: 200-300

《Novel preparation of poly(arylene ether sulfone amide)s via supported palladium-catalyzed carbonylative polymerization》 was published in Polymer Bulletin (Heidelberg, Germany) in 2020. These research results belong to Liu, Limin; Li, Jianying; Yan, Tao; Cai, Mingzhong. SDS of cas: 626-02-8 The article mentions the following:

Two new aromatic diiodides with ether-sulfone linkages were synthesized via a 1-step procedure. Poly(arylene ether sulfone amide)s were synthesized by a supported Pd-catalyzed polycondensation of aromatic diiodides having ether-sulfone linkages, aromatic diamines, and CO. Polycondensation reactions were conducted in N,N-dimethylacetamide using a magnetic nanoparticles-bound Pd(II) complex [Fe3O4@SiO2-2P-PdCl2] as the catalyst and 1,8-diazabicycle[5,4,0]-7-undecene as the base at 120°, yielding poly(arylene ether sulfone amide)s having inherent viscosities of 0.43-0.77 dL/g. The resulting polymers were soluble in polar aprotic solvents and showed glass transition temperatures in the 204-265° range, with 10% weight losses occurring at temperatures >456° in N. Most of the polymers afforded transparent and tough films by solution-casting with tensile strengths of 71.8-82.2 MPa, Young’s moduli of 1.77-2.35 GPa, and elongations at break of 9.3-13.4%. More importantly, this supported Pd catalyst can facilely be separated from the product by simply using an external magnetic field and reused at least 7 times with almost consistent activity. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8SDS of cas: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. SDS of cas: 626-02-8 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Ni-Catalyzed Reductive Dicarbofunctionalization of Nonactivated Alkenes: Scope and Mechanistic Insights》 were Shu, Wei; Garcia-Dominguez, Andres; Quiros, M. Teresa; Mondal, Rahul; Cardenas, Diego J.; Nevado, Cristina. And the article was published in Journal of the American Chemical Society in 2019. Safety of 1-Iodo-4-methylbenzene The author mentioned the following in the article:

Olefins devoid of directing or activating groups have been dicarbofunctionalized here with two electrophilic carbon sources under reductive conditions. Simultaneous formation of one C(sp3)-C(sp3) and one C(sp3)-C(sp2) bond across a variety of unbiased π-systems proceeds with exquisite selectivity by the combination of a Ni catalyst with TDAE as sacrificial reductant. Control experiments and computational studies revealed the feasibility of a radical-based mechanism involving, formally, two interconnected Ni(I)/Ni(III) processes and demonstrated the different ability of Ni(I) species (Ni(I)I vs PhNi(I)) to reduce the C(sp3)-I bond. The role of the reductant was also investigated in depth, suggesting that a one-electron reduction of Ni(II) species to Ni(I) is thermodynamically favored. Further, the preferential activation of alkyl vs aryl halides by ArNi(I) complexes as well as the high affinity of ArNi(II) for secondary over tertiary C-centered radicals explains the lack of undesired homo- and direct coupling products (Ar-Ar, Ar-Alk) in these transformations. In addition to this study using 1-Iodo-4-methylbenzene, there are many other studies that have used 1-Iodo-4-methylbenzene(cas: 624-31-7Safety of 1-Iodo-4-methylbenzene) was used in this study.

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Safety of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Metal-Free Electrophilic Alkynylation of Sulfenate Anions with Ethynylbenziodoxolone Reagents》 were Amos, Stephanie G. E.; Nicolai, Stefano; Gagnebin, Alec; Le Vaillant, Franck; Waser, Jerome. And the article was published in Journal of Organic Chemistry in 2019. Product Details of 88-67-5 The author mentioned the following in the article:

Alkynyl sulfoxides are important building blocks with a unique reactivity in organic chem., but only a few reliable methods have been reported to synthesize them. A novel route to access alkynyl sulfoxides is reported herein by using ethynyl benziodoxolone (EBX) reagents to trap sulfenate anions generated in situ, via a retro-Michael reaction. The reaction takes place under metal-free and mild conditions. It is compatible with aryl, heteroaryl, and alkyl sulfoxides with up to 90% yield. This practical access to alkynyl sulfoxides is expected to facilitate the application of these useful building blocks in organic synthesis. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Product Details of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Product Details of 88-67-5Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Reaction-based fluorometric analysis of N-bromosuccinimide by oxidative deprotection of dithiane》 were Lee, Yu Jeong; Choi, Myung Gil; Park, Tae Jung; Chang, Suk-Kyu. And the article was published in Analyst (Cambridge, United Kingdom) in 2019. Electric Literature of C4H4INO2 The author mentioned the following in the article:

In this study, a fluorescent probe is developed for the first time for N-bromosuccinimide (NBS), a synthetically and anal. important compound Pyrene-dithiane-based probe 1 showed prominently selective and sensitive signaling behavior toward NBS owing to the oxidative cleavage of the dithiane protecting group of 1-pyrenecarboxaldehyde. The NBS-selective signaling of the probe was possible under competitive conditions in the presence of common metal ions and anions as a background. The detection limit of the probe for NBS was found to be 5.6 × 10-8 M (10.0 ppb). The signaling product was sufficiently stable under the oxidative stress of NBS in contrast to another tested compound, 6-methoxy-2-naphthaldehyde-based dithiane derivative 2, which showed a gradually decaying response because of the reaction of the signaling product with the residual NBS. In the practical application of the probe, a smartphone was used as a stand-alone device, and the fluorometric assays of the com. NBS reagents could be conducted rapidly and in a convenient manner. After reading the article, we found that the author used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Electric Literature of C4H4INO2)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Electric Literature of C4H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Chinese Journal of Structural Chemistry included an article by Hui, Jia; Zhong, Han-Yu; Zhang, Jing-Yi. COA of Formula: C3H9IOS. The article was titled 《Synthesis, crystal structure and bioactivity of ethyl 1 1-((2 2-Bromophenyl)carbamoyl) carbamoyl)-2-(3,4,5 3,4,5- trimethoxyphenyl)cyclopropanecarboxylate》. The information in the text is summarized as follows:

Many small-mol. compounds were reported as microtubule-inhibitor with potential anticancer activities, such as combretastatin-A4 (CA-4) analog. The title compound which is one novel cyclopropylamide analog of CA-4, namely as Et 1-((2-bromophenyl)car- bamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n with a = 8.8002 ( 6), b = 11.4525(8), c = 21.7870(16) Å, beta = 93.810(3)°, V = 2190.9(3) Å3, Z = 4, C22H23BrNO6, Mr = 477.32477.32, Dc = 1. 447 Mg /cm3, F(000) = 980, (CuKa) = 1.54178 Å, mu = 2.883 mm-1, R = 0.0691 and wR = 0.1958 for 6420 observed reflections (I > 2s(I)). Importantly, the compound revealed potential anticancer activities in six cancer cells and could stimulate tubulin polymerization in vitro, indicating that the small-mol. could be selected as a lead compound for the development of microtubule stimulator. In the experiment, the researchers used many compounds, for example, Trimethylsulfoxonium iodide(cas: 1774-47-6COA of Formula: C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.COA of Formula: C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Chowdhury, Sushobhan; Vaishnav, Roopal; Panwar, Namita; Haq, Wahajul. Related Products of 625-99-0. The article was titled 《Regioselective β-Csp3-arylation of β-alanine: An approach for the exclusive synthesis of diverse β-aryl-β-amino acids》. The information in the text is summarized as follows:

An approach for the synthesis of a variety of new β-aryl-β-amino acids has been developed via a palladium-catalyzed auxiliary-directed regioselective Csp3-H arylation of the unactivated β-methylene bond of β-alanine. The use of 8-aminoquinoline amide as an auxiliary efficiently directs the desired regioselective β-Csp3-H functionalization. The developed protocol enables the easy and straightforward access to several high-value β-aryl-β-amino acids useful for peptide engineering, starting from inexpensive and readily available β-alanine precursors in moderate to excellent yields. The experimental part of the paper was very detailed, including the reaction process of 1-Chloro-3-iodobenzene(cas: 625-99-0Related Products of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Related Products of 625-99-0 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Pramanick, Pranab K.; Zhou, Zhibing; Hou, Zhen-Lin; Yao, Bo. Application In Synthesis of 1-Bromo-4-iodobenzene. The article was titled 《Free Amino Group-Directed γ-C(sp3)-H Arylation of α-Amino Esters with Diaryliodonium Triflates by Palladium Catalysis》. The information in the text is summarized as follows:

Free amino group-directed C(sp3)-H functionalization of aliphatic amines is a fundamental challenge in synthetic organic chem. Also, the NH2-directed C(sp3)-H functionalization of α-amino acids and their derivatives remains barely explored. With palladium as the catalyst and Ag2O as the additive, the authors developed the first NH2-directed γ-C(sp3)-H arylation of α-amino esters with diaryliodonium triflates for the construction of synthetically useful γ-aryl-α-amino esters, and the result of the KIE study suggested that the catalytic reaction involved an irreversible C-H cleavage as the rate-determining step. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-iodobenzene(cas: 589-87-7Application In Synthesis of 1-Bromo-4-iodobenzene)

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesApplication In Synthesis of 1-Bromo-4-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,del Aguila-Sanchez, Miguel A.; Navarro, Yolanda; Garcia Lopez, Jesus; Guedes, Guilherme P.; Lopez Ortiz, Fernando published 《Synthesis of P-stereogenic diarylphosphinic amides by directed lithiation: transformation into tertiary phosphine oxides via methanolysis, aryne chemistry and complexation behaviour toward zinc(II)》.Dalton Transactions published the findings.Name: 1,2-Diiodoethane The information in the text is summarized as follows:

The highly diastereoselective synthesis of P-stereogenic phosphinic amides via directed ortho lithiation (DoLi) of (SC)-P,P-diphenylphosphinic amides with t-BuLi followed by electrophilic quench reactions is described. Functionalized derivatives containing a wide variety of ortho substituents (Cl, Br, I, OH, N3, SiMe3, SnMe3, P(O)Ph2, Me, allyl, tBuOCO) have been prepared in high yields with diastereomeric ratios up to 98:2. The X-ray diffraction structure of the ortho-stannylated and ortho-iodo compounds showed that the pro-S P-Ph ring was stereoselectively ortho-deprotonated by the organolithium base. The usefulness of the method is supported by two key transformations, the synthesis of P-stereogenic Me phosphinates through replacement of the chiral auxiliary by a methoxy group and the first example of the insertion of benzyne into the P-N bond of a P-stereogenic phosphinic amide. A DFT study of this reaction showed that the insertion proceeds through a [2+2] cycloaddition and a subsequent ring-opening with retention of the P-configuration. Explorative coordination chem. of the new P-stereogenic ligands provided access to a chiral phosphinic amide-phosphine oxide Zn(II) complex, the crystal structure of which is reported.1,2-Diiodoethane(cas: 624-73-7Name: 1,2-Diiodoethane) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Lal, Nand; Jangir, Santosh; Bala, Veenu; Mandalapu, Dhanaraju; Sarswat, Amit; Kumar, Lalit; Jain, Ashish; Kumar, Lokesh; Kushwaha, Bhavana; Pandey, Atindra K.; Krishna, Shagun; Rawat, Tara; Shukla, Praveen K.; Maikhuri, Jagdamba P.; Siddiqi, Mohammad I.; Gupta, Gopal; Sharma, Vishnu L. published 《Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology》.European Journal of Medicinal Chemistry published the findings.Recommanded Product: 624-73-7 The information in the text is summarized as follows:

Trichomoniasis and candidiasis are amongst the most common morbidity-causing reproductive tract infections, generally treated by Metronidazole and Fluconazole resp. Poor vaginal efficacy, drug-resistance and non-spermicidal nature limit their use as topical microbicidal contraceptives. Bis(dialkylaminethiocarbonyl)disulfides were designed as dually active, non-surfactant mols. capable of eliminating Trichomonas vaginalis and Candida strains as well as irreversibly immobilizing 100% human sperm instantly, at doses non-cytotoxic to human cervical epithelial cells and vaginal microflora in vitro. Compounds bis(4-butyl-1-piperazinylthiocarbonyl) disulfide (12), bis(4-allyl-1-piperazinylthiocarbonyl) disulfide (16), bis[4-(3-cyanoproyl)-1-piperazinylthiocarbonyl] disulfide (17) were fifty times more active than nonoxynol-9, OTC vaginal spermicide, and compounds 12 and 17 have shown remarkable in vivo activity in rabbit model. Most promising compound 17 has shown promise for further development as a double-edged vaginal microbicide due to their improved activity and safety along with notable in vivo trichomonicidal activity. Role of disulfide group was established by loss of spermicidal activity on chem. modifications. These disulfides might be targeting thiol groups present over cell membrane of human sperm and Trichomonas as shown by fluorescence labeling of free thiols.1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 624-73-7) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Recommanded Product: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《R-Benzylidenehydrazides of NH-Furoyl-5-Iodoanthranilic Acids: Synthesis, Properties, and Analgesic and Antibacterial Activity》 were Gazizova, A. F.; Kurbatov, E. R.; Makhmudov, R. R.; Bobyleva, A. A.; Korkodinova, L. M.; Kurbatova, A. A.. And the article was published in Pharmaceutical Chemistry Journal in 2019. Synthetic Route of C7H5IO The author mentioned the following in the article:

A series of R-benzylidenehydrazides of NH-furoyl-5-iodoanthranilic acid were synthesized by condensing NH-furoyl-5-iodoanthranilic acid hydrazide with aromatic aldehydes. Their structures were confirmed using IR and PMR spectroscopy. Their analgesic and antibacterial activities were studied. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Synthetic Route of C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Synthetic Route of C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com