Tag: 200-300

Recommanded Product: 624-73-7In 2018 ,《Mechanism of SmI2 Reduction of 5-Bromo-6-oxo-6-phenylhexyl Methanesulfonate Studied by Spin Trapping with 2-Methyl-2-nitrosopropane》 was published in Journal of Organic Chemistry. The article was written by Aretz, Christopher D.; McPeak, Joseph E.; Eaton, Gareth R.; Eaton, Sandra S.; Cowen, Bryan J.. The article contains the following contents:

The radical formed by reduction of 5-bromo-6-oxo-6-phenylhexyl methanesulfonate, an α-bromoketone, with SmI2 was spin trapped with 2-methyl-2-nitrosopropane. ESR spectra of the spin adduct and the adduct formed in the analogous reaction with selectively deuterated substrate identify the radical intermediate in this SmI2 reduction as a carbon-centered radical. This result supports the proposal that the formation of reactive Sm-enolates arises from reduction of the carbon-bromine bond rather than a ketyl radical anion. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Safety of 3-IodophenolIn 2021 ,《Magnetic covalently immobilized nickel complex: A new and efficient method for the Suzuki cross-coupling reaction》 appeared in Applied Organometallic Chemistry. The author of the article were Keyhaniyan, Mahdi; Khojastehnezhad, Amir; Eshghi, Hossein; Shiri, Ali. The article conveys some information:

An efficient procedure is reported to prepare Fe3O4@SiO2 magnetic nanoparticles (MNPs) with immobilized nickel NPs. In order to increase the activity of this catalyst, creatine as a ligand with high content of nitrogen atoms was linked onto the magnetic core-shell structure. Then, Ni(II) ions were coordinated on the surface of the silica-coated MNPs and reduced to Ni(0) NPs to obtain the final catalyst. The catalytic activity of the prepared catalyst was studied for the synthesis of biaryl derivatives via the Suzuki-Miyaura cross-coupling reaction in high yields. The catalyst could also be recovered and reused with no loss of activity over five successful runs. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Safety of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Safety of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Sen, Anirban; Kumar, Rohit; Pandey, Swechchha; Vipin Raj, K.; Kumar, Pawan; Vanka, Kumar; Chikkali, Samir H. published an article in European Journal of Organic Chemistry. The title of the article was 《Mechanistically Guided One Pot Synthesis of Phosphine-Phosphite and Its Implication in Asymmetric Hydrogenation》.Recommanded Product: 626-02-8 The author mentioned the following in the article:

Although hybrid bidentate ligands are known to yield highly enantioselective products in asym. hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an O-nucleophile vs. C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72%). When L1 was treated with [Rh], 31P NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92%). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1-2 bar H2 pressure, at room temperature The practical relevance of L1 is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson’s disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer. In the part of experimental materials, we found many familiar compounds, such as 3-Iodophenol(cas: 626-02-8Recommanded Product: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Siyabalapitiya Arachchige, Sameera; Crich, David published an article in Organic Letters. The title of the article was 《Syntheses of Legionaminic Acid, Pseudaminic Acid, Acetaminic Acid, 8-epi-Acetaminic Acid, and 8-epi-Legionaminic Acid Glycosyl Donors from N-Acetylneuraminic Acid by Side Chain Exchange》.Category: iodides-buliding-blocks The author mentioned the following in the article:

Metaperiodate cleavage of the glycerol side chain from an N-acetyl neuraminic acid-derived thioglycoside and condensation with the two enantiomers of the Ellman sulfinamide afford two diastereomeric N-sulfinylimines from which bacterial sialic acid donors with the legionaminic and acetaminic acid configurations and their 8-epi-isomers are obtained by samarium iodide-mediated coupling with acetaldehyde and subsequent manipulations. A variation on the theme, with inversion of the configuration at C5, similarly provides two differentially protected pseudaminic acid donors. In the experiment, the researchers used 1,2-Diiodoethane(cas: 624-73-7Category: iodides-buliding-blocks)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Oda, Susumu; Sugitani, Takumi; Tanaka, Hiroyuki; Tabata, Keita; Kawasumi, Ryosuke; Hatakeyama, Takuji published an article in Advanced Materials (Weinheim, Germany). The title of the article was 《Development of Pure Green Thermally Activated Delayed Fluorescence Material by Cyano Substitution》.Category: iodides-buliding-blocks The author mentioned the following in the article:

Multiple resonance (MR)-effect-induced thermally activated delayed fluorescence (TADF) materials have garnered significant attention because they can achieve both high color purity and high external quantum efficiency (EQE). However, the reported green-emitting MR-TADF materials exhibit broader emission compared to those of blue-emitting ones and suffer from severe efficiency roll-off due to insufficient rate constants of reverse intersystem crossing process (kRISC). Herein, a pure green MR-TADF material (ν-DABNA-CN-Me) with high kRISC of 105 s-1 is reported. The key to success is introduction of cyano groups into a blue-emitting MR-TADF material (ν-DABNA), which causes remarkable bathochromic shift without a loss of color purity. The organic light-emitting diode employing it as an emitter exhibits green emission at 504 nm with a small full-width at half-maximum of 23 nm, corresponding to Commission Internationale d’Eclairage coordinates of (0.13, 0.65). The device achieves a high maximum EQE of 31.9% and successfully suppresses the efficiency roll-off at a high luminance. In the experiment, the researchers used 1-Chloro-3-iodobenzene(cas: 625-99-0Category: iodides-buliding-blocks)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides.Category: iodides-buliding-blocks The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wang, Yang; Zhang, Feng; Wang, Yi; Pan, Yi published an article in European Journal of Organic Chemistry. The title of the article was 《Electrochemistry Enabled Nickel-Catalyzed Selective C-S Bond Coupling Reaction》.Synthetic Route of C5H4IN The author mentioned the following in the article:

This work describes an electrochem. enabled nickel-catalyzed chemoselective C-S bond coupling protocol for the production of aryl sulfides and sulfones. By simply switching the nickel catalysts and electrodes, this electrochem. C-S bond coupling has demonstrated excellent redox activity, scalability and sustainability. Furthermore, the mechanism for this electrochem. cross-coupling reaction has been investigated.4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN) was used in this study.

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Das, Krishna Mohan; Pal, Adwitiya; Adarsh, Nayarassery N.; Thakur, Arunabha published an article in 2022. The article was titled 《A novel quinoline-based NNN-pincer Cu(II) complex as a superior catalyst for oxidative esterification of allylic C(sp3)-H bonds》, and you may find the article in Organic & Biomolecular Chemistry.HPLC of Formula: 88-67-5 The information in the text is summarized as follows:

A quinoline-based NNN-pincer Cu(II) complex acts as an air stable superior catalyst for the oxidative cross-coupling of the allyl sp3 C-H bond with an acid for the synthesis of allyl esters in a homogeneous system at ambient temperature The synthesized catalyst, Cu(II) complex has been well characterized by various anal. techniques (HRMS, single crystal X-ray diffraction, CV, EPR, UV-vis spectroscopy) and showed excellent catalytic activity for the oxidative esterification of allylic C(sp3)-H bonds at 40°C within a very short period of time (1 h) using only 1 mol% of the catalyst. A wide variety of aromatic allylic esters were synthesized in moderate to good yields, which could be extended to aliphatic allyl esters as well. The results came from multiple reactions, including the reaction of 2-Iodobenzoic acid(cas: 88-67-5HPLC of Formula: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.HPLC of Formula: 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Parashar, Mritunjaya; Singh, Ranbir; Yoo, Kicheon; Lee, Jae-Joon published an article in 2021. The article was titled 《Formation of 1-D/3-D Fused Perovskite for Efficient and Moisture Stable Solar Cells》, and you may find the article in ACS Applied Energy Materials.Category: iodides-buliding-blocks The information in the text is summarized as follows:

Various organic cations (e.g., methylammonium (MA+), butylammonium (BA+), formamidinium (FA+), etc.) have been studied and used in organometallic halide perovskite solar cells (PSCs). Most of the currently used organic cations are protic in nature, which can induce acid-base reactions and, thus, lead to degradation of the perovskites. So far, the role of aprotic cations in PSCs has not been studied much. In the present study, two aprotic cations, namely, trimethylsulfonium (TMS+) and trimethylsulfoxonium (TMSO+), are introduced into lead-based PSCs to form one-dimensional/three-dimensional (TMSPbI3)x(MAPbI3)100-x and (TMSOPbI3)x(MAPbI3)100-x perovskite structures, resp. This is shown to provide enhanced performance and moisture resistance, thus, increasing the stability and lifespan of the PSCs. The power conversion efficiencies of the (TMSPbI3)x(MAPbI3)100-x and (TMSOPbI3)x(MAPbI3)100-x devices are found to be 19.34 and 19.94%, resp., compared to 17.11% for the pristine MAPbI3 PSC, along with enhanced open-circuit voltages (VOC) of 1.14 and 1.12 V, resp., compared to 1.07 V for the pristine MAPbI3 PSC. Furthermore, the effects of TMS+ and TMSO+ upon the perovskite structure, absorption, recombination, and film morphol. are discussed in detail. The results of this study will be helpful in the exploration of sulfur-based cations for the development of more stable PSCs. In the experiment, the researchers used Trimethylsulfoxonium iodide(cas: 1774-47-6Category: iodides-buliding-blocks)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chaisan, Nattawadee; Ruengsangtongkul, Sureeporn; Tummatorn, Jumreang; Ruchirawat, Somsak; Chainok, Kittipong; Thongsornkleeb, Charnsak published an article in 2021. The article was titled 《Dibrominative Spirocyclization of 2-Butynolyl Anilides: Synthesis of gem-Dibromospirocyclic Benzo[d][1,3]oxazines and Their Application in the Synthesis of 4H-Furo[3,2-b]indoles》, and you may find the article in Journal of Organic Chemistry.Quality Control of 4-Chloro-2-iodoaniline The information in the text is summarized as follows:

The combination of catalytic aqueous hydrochloric acid (HCl) and N-bromosuccinimide (NBS) generated electrophilic bromine monochloride (BrCl), which readily induced spiroannulation of 2-alkynolyl anilides I (n = 1,2, X = Cl, Br; n = 3, X = Br; R1 = H, 6-Me, 7-Cl, 6-CN, etc.; R2 = Ph, tert-Bu, cyclohexyl, etc.; R3 = H, Ph) to form gem-dibromospirocyclic benzo[d][1,3]oxazines II in up to 92% yield. The reaction occurred under mild and metal-free conditions using EtOAc as a green solvent. The resulted spirocyclic products contained benzo[d][1,3]oxazine II, which was useful both as a pharmacophore and synthetic precursor. In addition, the current protocol allowed to effortlessly introduce the sp3-gem-dibromide carbon adjacent to the sterically demanding spiroketal center. These spiroheterocycles (n = 1) were shown to be synthetically versatile and conveniently maneuvered. Base-promoted debrominative aromatization of these spirocycles II (n = 1; X = Br) unmasked rare and synthetically useful 2-aryl-3-bromofurans III in mostly excellent yields. These 3-bromofurans III were well-suited substrates for intramol. Ullmann C-N bond coupling to construct difficult-to-prepare 4H-furo[3,2-b]indoles IV. Addnl., the current protocol was flexible and adaptable to prepare the gem-dichloride variants. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Quality Control of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Quality Control of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pipitone, Candida; Giannici, Francesco; Martorana, Antonino; Garcia-Espejo, Gonzalo; Carlotto, Silvia; Casarin, Maurizio; Guagliardi, Antonietta; Masciocchi, Norberto published their research in Journal of Physical Chemistry C in 2021. The article was titled 《Heterovalent BiIII/PbII Ionic Substitution in One-Dimensional Trimethylsulfoxonium Halide Pseudo-Perovskites (X = I, Br)》.Application of 1774-47-6 The article contains the following contents:

The authors report on the synthesis and characterization of novel lead and Bi hybrid (organic-inorganic) iodide and bromide pseudo-perovskites (ABX3) containing the trimethylsulfoxonium cation Me3SO+ (TMSO) in the A site, Pb/Bi in the B site, and Br or I as X anions. All of these compounds are isomorphic and crystallize in the orthorhombic Pnma space group. Pb-based pseudo-perovskites consist of 1-dimensional (1D) chains of face-sharing [PbX6] octahedra, while in the Bi-based ones, the chains of [BiX6] are interrupted, with one vacancy every 3rd site, leading to a zero-dimensional (0-D) local structure based on separated [Bi2I9]3- dimers. Five solid solutions for the iodide with different Pb2+/Bi3+ ratios between (TMSO)PbI3 and (TMSO)3Bi2I9, and two for the bromide counterparts, were synthesized. Due to the charge compensation mechanism, these systems are best described by the (TMSO)3Pb3xBi2(1-x)I9 (x = 0.98, 0.92, 0.89, 0.56, and 0.33) and (TMSO)3Pb3xBi2(1-x)Br9 (x = 0.83 and 0.37) formulas. X-ray powder diffraction (XRPD) measurements were employed to determine the crystal structure of all studied species and further used to test the metal cation miscibility within monophasic samples not showing cation segregation. These systems can be described through an ionic defectivity on the pseudo-perovskite B site, where the Pb2+/Bi3+ replacement is compensated by one Pb2+ vacancy for every Bi3+ pair. This leads to a wide range of possible different (numerical and geometrical) chain configurations, leading to the unique features observed in XRPD patterns. The optical band gap of the iodide samples falls in the 2.11-2.74 eV range and decreases upon increasing the Bi3+ content. Even a very low loading of Bi3+ (1%) is sufficient to reduce the band gap substantially from 2.74 to 2.25 eV. Periodic d. functional theory (DFT) calculations were used to simulate the at. and electronic structures of the authors’ samples, with predicted band gap trends in good agreement with the exptl. ones. This work highlights the structural flexibility of such systems and accurately interprets the ionic defectivity of the different pseudo-perovskite structures. In the experimental materials used by the author, we found Trimethylsulfoxonium iodide(cas: 1774-47-6Application of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Application of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com