Tag: 200-300

Reference of 4-Iodobenzoic acidIn 2020 ,《Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Yamasaki, Toshihide; Azuma, Risa; Sano, Kohei; Munekane, Masayuki; Matsuoka, Yuta; Yamada, Ken-ichi; Mukai, Takahiro. The article conveys some information:

Thus far, no accurate measurement technol. has been developed to detect lipid alkyl radicals (lipid radicals), which cause lipid peroxidation Therefore, we aimed to develop a nuclear medical imaging probe that can be taken up in the lipophilic site in cells such as biol. membranes, by reacting specifically with the lipid radicals generated there. We designed and synthesized 4-(4-[125I]iodobenzamido)-2,2,6,6-tetramethylpiperidine-1-oxyl (I), which shows high reactivity to lipid radicals with a high radiochem. yield and purity. Intracellular retention was found to increase significantly when lipid radicals were produced. In the experiment, the researchers used 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Reference of 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Le Vaillant, Franck; Mateos Calbet, Ana; Gonzalez-Pelayo, Silvia; Reijerse, Edward J.; Ni, Shengyang; Busch, Julia; Cornella, Josep published an article in Nature (London, United Kingdom). The title of the article was 《Catalytic synthesis of phenols with nitrous oxide》.Reference of 1-Bromo-3-iodobenzene The author mentioned the following in the article:

Here, an insertion of N2O into a Ni-C bond under mild conditions (room temperature, 1.5-2 bar N2O) for delivering valuable phenols ROH (R = Ph, 4-cyanophenyl, 1-oxo-2,3-dihydro-1H-inden-4-yl, quinolin-6-yl, etc.) and releasing benign N2 was reported. This fundamentally distinct organometallic C-O bond-forming step differs from the current strategies based on reductive elimination and enables an alternative catalytic approach for the conversion of aryl halides RX (X = I, Br) to phenols. The process was rendered catalytic by means of a bipyridine-based ligands for the Ni center. The method is robust, mild and highly selective, and able to accommodate base-sensitive functionalities as well as permitting phenol synthesis from densely functionalized aryl halides. Although this protocol does not provide a solution to the mitigation of N2O emissions, it represents a reactivity blueprint for the mild revalorization of abundant N2O as an O source. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-iodobenzene(cas: 591-18-4Reference of 1-Bromo-3-iodobenzene)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Reference of 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Pal, Debasish; Chaudhury, Aritra; Mukhopadhyay, Balaram published an article in European Journal of Organic Chemistry. The title of the article was 《Chemical Synthesis of the Linker-Armed Trisaccharide Repeating Unit of the O-Antigen from Pseudomonas putida BIM B-1100》.Computed Properties of C4H4INO2 The author mentioned the following in the article:

The manuscript reports the concise chem. synthesis of the trisaccharide repeating unit of the O-antigen from Pseudomonas putida BIM B-1100 in the form of its aminoethyl glycoside through a linear strategy with rational protecting group manipulations. The challenging aspects of this synthesis include the incorporation of the β-D-ManpNAcA and the α-D-GlcpNAc residues. The introduction of the desired carboxylic acid moiety has been achieved through late-stage TEMPO-mediated oxidation of the primary OH group on the protected trisaccharide. 1,2-cis aminoethyl glycoside with central glucosamine is used at the reducing end to the leave the scope for further glycoconjugate formation with suitable aglycon without hampering the anomeric stereochem. After reading the article, we found that the author used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Computed Properties of C4H4INO2)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Computed Properties of C4H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Manenti, Marco; Gusmini, Simone; Lo Presti, Leonardo; Silvani, Alessandra published an article in European Journal of Organic Chemistry. The title of the article was 《Exploiting Enantiopure β-Amino Boronic Acids in Isocyanide-Based Multicomponent Reactions》.Formula: C7H5IO2 The author mentioned the following in the article:

Various isocyanide-based multicomponent reactions prove to be highly reliable when β-substituted β-amino boronic esters are employed as the amine component, allowing the efficient synthesis of unprecedented peptidomimetics and heteroatom-rich boron-containing small mols. In particular, the scope of the Ugi reaction is widely exploited, to give a family of enantiopure β-substituted β-amido boronates. The Ugi-azide and the van Leusen reactions allow to joint together prominent pharmacophoric moieties, such as β-amino boronic acids on one side, and tetrazole or imidazole rings on the other side, realizing a successful application of the mol. hybridization concept. In the part of experimental materials, we found many familiar compounds, such as 2-Iodobenzoic acid(cas: 88-67-5Formula: C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C7H5IO2 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Cai, Chen; Lu, Yi; Yuan, Chengcheng; Fang, Zheng; Yang, Xiaobing; Liu, Chengkou; Guo, Kai published an article in ACS Sustainable Chemistry & Engineering. The title of the article was 《Metal-Free C-C Cross Coupling: Electrosynthesis of Azaheterocycles through Anodic Oxidation Cyclization of 1,6-Enynes》.Application In Synthesis of 4-Chloro-2-iodoaniline The author mentioned the following in the article:

A straightforward synthesis of azaheterocycles has been developed through electrochem. aerobic oxidation cyclization using a user-friendly undivided electrolytic cell at room temperature under catalyst-free conditions. This green and practical electrosynthesis strategy features good functional group, diverse electronic and steric properties tolerance. Based on a series of mechanistic investigation, including isotope labeling, singlet oxygen inhibiting, superoxide radical anion inhibiting, radical-trapping, cyclic voltammetry and controlled potential electrolysis experiments, a possible N-centered radical-initiated mechanism was proposed. The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Application In Synthesis of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application In Synthesis of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Guadalupe, Albarran; Rosalba, Ramos-Morales; Edith, Mendoza published an article in 2021. The article was titled 《Oxidation of halobenzenes by OH radical produced radiolytically in aqueous solution》, and you may find the article in Radiation Physics and Chemistry.Recommanded Product: 626-02-8 The information in the text is summarized as follows:

The radiolytic oxidation of aromatic compounds in dilute aqueous solution is due to the electrophilic strength of the •OH that results from the radiolysis of water. This radical is preferentially added to the electron-rich centers in aromatic rings. Therefore, studies of the charge distribution of the hydroxycyclohexadienyl radicals produced by the addition of the •OH to the aromatics can provide information about their charge distribution. In the present work, the radiolytic oxidation reaction of fluorobenzene, chlorobenzene, bromobenzene, and iodobenzene with the •OH in diluted aqueous solutions was studied. The identification and quantification of the radiolytic products thus formed were carried out utilizing HPLC. The yields found for fluorobenzene, chlorobenzene, bromobenzene, and iodobenzene were 0.609, 0.527, 0.508, and 0.501μmol/J, resp. The electron d. distribution in fluorobenzene, chlorobenzene, and bromobenzene was in the following order: for para > ortho > meta >> ipso; however, in iodobenzene, there is a higher electron d. in the “”ortho”” position than in the “”para”” position. From the total reaction rates for the halobenzenes with the •OH, the partial rate constants were obtained for the reaction of the •OH with each of the positions in the halobenzenes. In the part of experimental materials, we found many familiar compounds, such as 3-Iodophenol(cas: 626-02-8Recommanded Product: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Singh, Prabhakar; Arulananda Babu, Srinivasarao; Aggarwal, Yashika; Patel, Pooja published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Pd(II)-catalyzed, Picolinamide-aided sp2 γ-C-H Functionalization of Phenylglycinol: Access to γ-C-H Arylated, Alkylated and Halogenated Phenylglycinol Scaffolds》.HPLC of Formula: 625-99-0 The article contains the following contents:

The Pd(II)-catalyzed picolinamide-aided ortho-C-H arylation-, alkylation-, and halogenation (sp2 γ-C-H functionalization) of phenylglycinol substrates was reported. Phenylglycinols I [R = Ph, 4-BrC6H4, 4-MeC6H4, etc.; R1 = 2-pyridinecarboxamidyl; stereo = R, S, no stereo] were remarkable building blocks and have found different applications in synthetic organic and medicinal chem. This work was a contribution toward the expansion of the library of phenylglycinol scaffolds and also substrate scope development by using the Pd(II)-catalyzed bidentate directing group picolinamide-aided C-H activation tactic. The experimental part of the paper was very detailed, including the reaction process of 1-Chloro-3-iodobenzene(cas: 625-99-0HPLC of Formula: 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.HPLC of Formula: 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Four-Component Borocarbonylation of Vinylarenes Enabled by Cooperative Cu/Pd Catalysis: Access to β-Boryl Ketones and β-Boryl Vinyl Esters》 was written by Yuan, Yang; Wu, Fu-Peng; Xu, Jian-Xing; Wu, Xiao-Feng. Product Details of 625-99-0 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

We report here a general four-component synthetic procedure for the preparation of β-boryl ketones and β-boryl vinyl esters. Joint catalyzed by palladium and copper catalysts, borocarbonylative reaction between vinylarenes, aryl halides/triflates, B2Pin2, and carbon monoxide proceed successfully. A variety of synthetically useful β-boryl ketones were synthesized in good to high yields by using aryl iodides as the substrates. It is noteworthy that when aryl triflates were applied as the starting materials, β-boryl vinyl esters were synthesized in a similar manner and with broad functional group tolerance. A rational mechanism for this reaction was also proposed. In the experiment, the researchers used 1-Chloro-3-iodobenzene(cas: 625-99-0Product Details of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Product Details of 625-99-0 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《[18F]ZCDD083: A PFKFB3-Targeted PET Tracer for Atherosclerotic Plaque Imaging》 was written by De Dominicis, Carlo; Perrotta, Paola; Dall′Angelo, Sergio; Wyffels, Leonie; Staelens, Steven; De Meyer, G. R. Y.; Zanda, Matteo. Name: 1-Iodopyrrolidine-2,5-dione And the article was included in ACS Medicinal Chemistry Letters in 2020. The article conveys some information:

PFKFB3, a glycolysis-related enzyme upregulated in inflammatory conditions and angiogenesis, is an emerging target for diagnosis and therapy of atherosclerosis. The fluorinated phenoxindazole [18F]ZCDD083 was synthesized, radiolabeled in 17 ± 5% radiochem. yield and >99% radiochem. purity, and formulated for preclin. PET/CT imaging in mice. In vivo stability anal. showed no significant metabolite formation. Biodistribution studies showed high blood pool activity and slow hepatobiliary clearance. Significant activity was detected in the lung 2 h postinjection (pi) (11.0 ± 1.5%ID/g), while at 6 h pi no pulmonary background was observed Ex vivo autoradiog. at 6 h pi showed significant high uptake of [18F]ZCDD083 in the arch region and brachiocephalic artery of atherosclerotic mice, and no uptake in control mice, matching plaques distribution seen by lipid staining along with PFKFB3 expression seen by immunofluorescent staining. In vivo PET scans showed higher aortic region uptake of [18F]ZCDD083 in atherosclerotic ApoE-/-Fbn1C1039G+/- than in control mice (0.78 ± 0.05 vs 0.44 ± 0.09%ID/g). [18F]ZCDD083 was detected in aortic arch and brachiocephalic artery of ApoE-/- (with moderate atherosclerosis) and ApoE-/-Fbn1C1039G+/- (with severe, advanced atherosclerosis) mice, suggesting this tracer may be useful for the noninvasive detection of atherosclerotic plaques in vivo. In addition to this study using 1-Iodopyrrolidine-2,5-dione, there are many other studies that have used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Name: 1-Iodopyrrolidine-2,5-dione) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Name: 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Enantio- and Regioselective NiH-Catalyzed Reductive Hydroarylation of Vinylarenes with Aryl Iodides》 was written by He, Yuli; Liu, Chuang; Yu, Lei; Zhu, Shaolin. Application In Synthesis of 4-Iodobenzaldehyde And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

A highly enantio- and regioselective hydroarylation process of vinylarenes with aryl halides has been developed using a NiH catalyst and a new chiral bis imidazoline ligand. A broad range of structurally diverse, enantio-enriched 1,1-diarylalkanes, a structure found in a number of biol. active mols., have been obtained with excellent yields and enantio-selectivities under extremely mild conditions. In the experiment, the researchers used 4-Iodobenzaldehyde(cas: 15164-44-0Application In Synthesis of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Application In Synthesis of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com