Tag: 200-300

In 2022,Gagne-Boulet, Mathieu; Bouzriba, Chahrazed; Chavez Alvarez, Atziri Corin; Fortin, Sebastien published an article in Chemical Biology & Drug Design. The title of the article was 《Preparation and biological evaluation of new antimicrotubule agents: Modification of the imidazolidin-2-one moiety of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates》.Synthetic Route of C6H5IO The author mentioned the following in the article:

We prepared and biol. evaluated 32 novel mols. named Ph 4-(dioxoimidazolidin-1-yl)benzenesulfonates (PID-SOs) and Et 2-(3-(4-(phenoxysulfonyl)phenyl)ureido)acetates (EPA-SOs). The antiproliferative activity of PID-SOs and EPA-SOs was assessed on four cancer cell lines (HT-1080, HT-29, M21, and MCF7). The most potent PID-SOs bearing an imidazolidin-2,4-dione group show antiproliferative activity in the nanomolar to low micromolar range (0.066 – 6 μM) while EPA-SOs and PID-SOs bearing an imidazolidin-2,5-dione moiety are mostly not active, exhibiting antiproliferative activity over 100 μM. The most potent PID-SOs (16-18) arrest the cell cycle progression in G2/M phase and interact with the colchicine-binding site leading to the microtubule and cytoskeleton disruption. Moreover, their antiproliferative activity is not impaired in vinblastine-, paclitaxel-, and multidrug-resistant cell lines. Finally, our study confirms that PID-SOs bearing the imidazolidin-2,4-dione moiety are a new family of promising antimitotics. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Synthetic Route of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Synthetic Route of C6H5IO Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Shao, Wenke; Wang, Qiufan; Zhang, Daohong published an article in Journal of Colloid and Interface Science. The title of the article was 《Defect engineering of P doped Fe7S8 porous nanoparticles for high-performance asymmetric supercapacitor and oxygen evolution electrocatalyst》.Safety of 1-Iodopyrrolidine-2,5-dione The author mentioned the following in the article:

Transition metal sulfides are promising battery-type materials for electrochem. energy storage and a great electrocatalyst for oxygen evolution reaction (OER). However, the poor conductivity and sluggish reaction kinetic as well as the deficiency of electrochem. active sites hinder the practical application of FexSy. Herein, we design Fe7S8 porous nanoparticles with surface phosphate ions and enriched sulfur-vacancies (P-Fe7S8), which is reported as a new high-specific-capacity material for asym. supercapacitor. Benefiting from the merits of substantially improved elec. conductivity and increased active sites, the optimized P-Fe7S8 neg. electrode delivers ultra-high specific capacitance of 804.7F/g at 0.4 mA. Moreover, the assembled NiS//P-Fe7S8 ASC presents an impressive specific capacitance of 335.9F/g at 1.2 A/g, a high energy d. of 134.8 Wh/kg at a power d. of 1042.1 W/kg, and great flexibility under different bending angles. Furthermore, the one-step vulcanization process is provided with universal applicability for the synthesis of NixFe1-xS bimetallic sulfide. With the synergy effect produced by the bimetal, the Ni0.5Fe0.5S hollow porous nanoparticles exhibit the remarkable activity of oxygen evolution reaction with a low overpotential of 174 mV at 10 mA cm-2 and Tafel slope of 41 mV dec-1. This simple method provides new insight into the synthesis of novel multifunctional metal sulfide nanomaterials. In the experiment, the researchers used many compounds, for example, 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Safety of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Safety of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Matheau-Raven, Daniel; Dixon, Darren J. published an article in Journal of Organic Chemistry. The title of the article was 《A One-Pot Synthesis-Functionalization Strategy for Streamlined Access to 2,5-Disubstituted 1,3,4-Oxadiazoles from Carboxylic Acids》.Product Details of 15854-87-2 The author mentioned the following in the article:

A one-pot 1,3,4-oxadiazole synthesis-arylation strategy for accessing 2,5-disubstituted 1,3,4-oxadiazoles I [R1 = 3-pyridyl, 4-MeC6H4, 1-phenylcyclopropyl, etc.; R2 = Ph, 4-pyridyl, morpholino, etc.], from carboxylic acids, N-isocyaniminotriphenylphosphorane (NIITP) and aryl iodides, was reported. The reaction sequence, featuring a second stage copper-catalyzed 1,3,4-oxadiazole arylation, was found to tolerate (hetero)aryl, alkyl, and alkenyl carboxylic acids, and (hetero)aryl iodide coupling partners. The effectiveness of the two-stage strategy was exemplified by the late-stage functionalization of five carboxylic acid-containing APIs, and, an extension to the synthesis of aminated 1,3,4-oxadiazoles using N-benzoyloxy amine coupling partners, was also demonstrated. In the experimental materials used by the author, we found 4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wang, Xiu; Pan, Shitao; Luo, Qinyu; Wang, Qian; Ni, Chuanfa; Hu, Jinbo published an article in Journal of the American Chemical Society. The title of the article was 《Controllable Single and Double Difluoromethylene Insertions into C-Cu Bonds: Copper-Mediated Tetrafluoroethylation and Hexafluoropropylation of Aryl Iodides with TMSCF2H and TMSCF2Br》.Electric Literature of C7H5IO The author mentioned the following in the article:

The selective difluoromethylene insertion into a C-Cu bond is a challenging task and is currently limited to either a single CF2 insertion into CuCF3 or double CF2 insertions into CuC6F5 (or (Z)-CF3CF = CFCu). Achieving both selective single and double CF2 insertions into the same C-Cu bond is even more difficult. Herein, highly controllable single and double CF2 insertions into CuCF2H species with a TMSCF2Br reagent have been described, affording two previously unknown fluoroalkylcopper species “”Cu(CF2)nCF2H”” (n = 1 and 2) independently under different reaction conditions. This work represents the first example of both single and double CF2 insertions into the same C-Cu bond in a highly selective manner. The synthetic value of the obtained “”Cu(CF2)nCF2H”” (n = 1 and 2) species is demonstrated by their reactions with aryl iodides, halogenation agents, and cinnamyl chloride, which enables the direct transfer of HCF2CF2 and HCF2CF2CF2 moieties into organic mols. The key to controllable fluorocarbon chain elongation from C1 to C2 and from C1 to C3 is presumably attributed to the different reactivities of “”Cu(CF2)nCF2H”” species (n = 0, 1, 2 and 3) and the loading of the TMSCF2Br reagent. In the experiment, the researchers used many compounds, for example, 4-Iodobenzaldehyde(cas: 15164-44-0Electric Literature of C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Electric Literature of C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Oda, Susumu; Kawakami, Bungo; Yamasaki, Yuki; Matsumoto, Ryuji; Yoshioka, Mayu; Fukushima, Daisuke; Nakatsuka, Soichiro; Hatakeyama, Takuji published an article in 2022. The article was titled 《One-Shot Synthesis of Expanded Heterohelicene Exhibiting Narrowband Thermally Activated Delayed Fluorescence》, and you may find the article in Journal of the American Chemical Society.Formula: C6H4ClI The information in the text is summarized as follows:

An expanded heterohelicene consisting of three BN2-embedded [4]helicene subunits (V-DABNA-Mes) was synthesized by 1-shot triple borylation. The key to success is the excessive use of B tribromide in an autoclave. Based on the multiple resonance effect of three B and six N atoms, V-DABNA-Mes exhibited a narrowband sky-blue thermally activated delayed fluorescence with a full width at half-maximum of 16 nm. The resonating π-extension minimized the singlet-triplet energy gap and enabled rapid reverse intersystem crossing with a rate constant of 4.4 × 105 s-1. The solution-processed organic light-emitting diode device, employed as an emitter, exhibited a narrowband emission at 480 nm with a high external quantum efficiency of 22.9%. The experimental process involved the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Formula: C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Formula: C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tang, Ying-Jie; Fang, Wen-Le; Ren, Kui; Guo, Xiao-Feng; Wang, Hong published an article in 2021. The article was titled 《A turn-on homodimer fluorescent probe based on homo-FRET for the sensing of biothiols in lysosome: a trial of a new turn-on strategy》, and you may find the article in Analyst (Cambridge, United Kingdom).HPLC of Formula: 15164-44-0 The information in the text is summarized as follows:

Fluorescence resonance energy transfer (FRET) is often applied to construct fluorescent probes for acquiring high selectivity and sensitivity. According to the FRET theory, a homodimer composed of two identical fluorophores with a small Stokes shift has only weak fluorescence due to homo-FRET between fluorophores, and the fluorescence could be recovered after the destruction of the homodimer. In this study, we designed and synthesized a homodimer fluorescent probe, namely 1,3,5,7-tetramethyl-8-(4′-phenylthiophenol)-boron difluoride-dipyrrole methane dimer (D-TMSPB), based on this turn-on strategy. In D-TMSPB, the disulfide moiety was selected as the response moiety of biothiols, and BODIPY fluorophore was chosen as both donor and acceptor in FRET due to the ultra-small Stokes shifts and obvious overlap of its excitation/emission peak. D-TMSPB exhibited only weak fluorescence. After selective reaction with biothiols, FRET was destroyed and the derivative exhibited strong fluorescence at 514 nm with the limit of detection of about 0.15 μM for GSH. Notably, the derivative of biothiols shows remarkable fluorescence only in acidic conditions, which accords with the internal environment of lysosome. Thus, D-TMSPB was applied to image the biothiols of lysosome in living cells. The turn-on fluorescence of D-TMSPB indicated that homo-FRET is a practical strategy to design turn-on fluorescent probes, particularly for the sensing mechanism based on leaving groups.4-Iodobenzaldehyde(cas: 15164-44-0HPLC of Formula: 15164-44-0) was used in this study.

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.HPLC of Formula: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Capilato, Joseph N.; Pellegrinelli, Peter J.; Bernard, Josephine; Schnorbus, Logan; Philippi, Shane; Mattiucci, Joseph; Hoy, Erik P.; Perez, Lark J. published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Acetyl nitrate mediated conversion of methyl ketones to diverse carboxylic acid derivatives》.Reference of 4-Iodobenzoic acid The article contains the following contents:

The development of a novel acetyl nitrate mediated oxidative conversion of Me ketones to carboxylic acid derivatives is described. By analogy to the haloform reaction and supported by exptl. and computational investigation authors propose a mechanism for this transformation. In the experiment, the researchers used 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Reference of 4-Iodobenzoic acidHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gao, Qianwen; Wu, Chenggui; Deng, Shuang; Li, Lisha; Liu, Ze-Shui; Hua, Yu; Ye, Jinxiang; Liu, Chang; Cheng, Hong-Gang; Cong, Hengjiang; Jiao, Yinchun; Zhou, Qianghui published their research in Journal of the American Chemical Society in 2021. The article was titled 《Catalytic Synthesis of Atropisomeric o-Terphenyls with 1,2-Diaxes via Axial-to-Axial Diastereoinduction》.Recommanded Product: 1-Iodonaphthalene The article contains the following contents:

A modular and convergent strategy for the assembly of atropisomeric o-terphenyls with 1,2-diaxes via palladium/chiral norbornene cooperative catalysis and axial-to-axial diastereoinduction was reported. Readily available aryl iodides, 2,6-substituted aryl bromides and potassium aryl trifluoroborates were used as the building blocks, laying the foundation for diversity-oriented synthesis of these scaffolds (46 examples). Other features included the unique axial-to-axial diastereoinduction mode, construction of two axes in a single operation and step economy. DFT calculations were performed to rationalize the axial-to-axial diastereoinduction process. Synthetic utilities of this method in preparation of atropisomeric oligophenyls, chiral catalysts and ligands were demonstrated. In the experiment, the researchers used 1-Iodonaphthalene(cas: 90-14-2Recommanded Product: 1-Iodonaphthalene)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Recommanded Product: 1-Iodonaphthalene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Martin, M. Trinidad; Marin, Mario; Maya, Celia; Prieto, Auxiliadora; Nicasio, M. Carmen published their research in Chemistry – A European Journal in 2021. The article was titled 《Ni(II) Precatalysts Enable Thioetherification of (Hetero)Aryl Halides and Tosylates and Tandem C-S/C-N Couplings》.Category: iodides-buliding-blocks The article contains the following contents:

Ni-catalyzed C-S cross-coupling reactions have received less attention compared with other C-heteroatom couplings. Most reported examples comprise the thioetherification of most reactive aryl iodides with aromatic thiols. The use of C-O electrophiles in this context is almost uncharted. Here, the authors describe that preformed Ni(II) precatalysts of the type NiCl(allyl)(PMe2Ar’) (Ar’=terphenyl group) efficiently couple a wide range of (hetero)aryl halides, including challenging aryl chlorides, with a variety of aromatic and aliphatic thiols. Aryl and alkenyl tosylates are also well tolerated, demonstrating, for the first time, to be competent electrophilic partners in Ni-catalyzed C-S bond formation. The chemoselective functionalization of the C-I bond in the presence of a C-Cl bond allows for designing site-selective tandem C-S/C-N couplings. The formation of the two C-heteroatom bonds takes place in a single operation and represents a rare example of dual electrophile/nucleophile chemoselective process.4-Iodopyridine(cas: 15854-87-2Category: iodides-buliding-blocks) was used in this study.

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Experimental and computational evidence on gold-catalyzed regioselective hydration of phthalimido-protected propargylamines: an entry to β-amino ketones》 was written by Marsicano, Vincenzo; Arcadi, Antonio; Aschi, Massimiliano; Michelet, Veronique. Safety of 1-Bromo-3-iodobenzene And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

The results of investigations on the Au-catalyzed regioselective hydration reaction of both alkyl- and aryl-substituted N-propargyl phthalimides I (R = CH3, C6H5, 2-thienyl, etc.) directed to the selective formation of the corresponding β-phthalimido ketones II are described. Exptl. data, in particular the observed regioselectivity, have been qual. supported by quantum-chem. calculations carried out on model systems in the framework of D. Functional Theory (DFT) followed by quantum theory of atoms in mols. (QTAIMS). The results suggest that the electronic features of the initial adduct between the propargyl triple bond and the Au(I) catalyst, in particular the character of the gold-triple bond interaction, are essential for the observed regioselectivity. Other effects, such as the presence of the solvent and the formation of a H-bond between the water mol. and the phthalimido moiety, although apparently irrelevant for the regioselectivity, have proven to be kinetically and catalytically rather important.1-Bromo-3-iodobenzene(cas: 591-18-4Safety of 1-Bromo-3-iodobenzene) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Safety of 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com