Tag: 200-300

The author of 《A novel strategy of transferring NIS protein to cells using extracellular vesicles leads to increase in iodine uptake and cytotoxicity》 were Son, Seung Hyun; Gangadaran, Prakash; Ahn, Byeong-Cheol. And the article was published in International Journal of Nanomedicine in 2019. Recommanded Product: 1-Iodopyrrolidine-2,5-dione The author mentioned the following in the article:

Background: This study was designed to explore a novel approach for transferring NIS protein to cells using extracellular vesicle (EV) and enhancing iodine avidity in hepatocellular carcinoma (HCC) cells. Methods: We transfected the HCC cells (Huh7) with NIS gene, designated as Huh7/NIS, and isolated the EVs from them. Presence of NIS protein in EVs and EV-mediated transport of NIS protein to recipient Huh7 cells were tested using Western blotting. We also examined radioiodine uptake in Huh7 cells treated with EV-Huh7/NIS. Results: Successful transfer of NIS protein into Huh7 cells was confirmed by WB and microscopy. EVs showed high levels of NIS protein in them. Treatment of Huh7 cells with EV-Huh7/NIS increased the NIS protein level and enhanced 125I uptake in recipient Huh7 cells. In addition, EV-huh7/NIS pre-treatment enhanced the cytotoxicity of 131I therapy against Huh7 cells by inducing increased DNA damage/increased γH2A.X foci formation. Conclusion: This is the first-of-its-kind demonstration of successful transportation of the NIS protein to cells via EVs, which increased radioiodine uptake. This approach can revert radioiodine-resistant cancers into radioiodine-sensitive cancers.1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Recommanded Product: 1-Iodopyrrolidine-2,5-dione) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Recommanded Product: 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of the American Chemical Society included an article by Lyu, Hairong; Zhang, Jie; Yang, Jingting; Quan, Yangjian; Xie, Zuowei. HPLC of Formula: 589-87-7. The article was titled 《Catalytic Regioselective Cage B(8)-H Arylation of o-Carboranes via “”Cage-Walking”” Strategy》. The information in the text is summarized as follows:

A proof-of-concept example of catalytic regioselective cage B(8)-H functionalization of o-carboranes was disclosed for the 1st time. Under the help of an acylamino directing group at cage B(3), B(8)-arylated, B(4,7,8)-triarylated and B(4,7,8)-trifluorinated o-carborane derivatives were conveniently prepared From isolation of a key intermediate, D labeling experiments and DFT calculations, a reaction mechanism involving a high-valent Pd induced cage-walking from B(4) to B(8) vertex is proposed to account for the regioselective B(8)-H activation. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-iodobenzene(cas: 589-87-7HPLC of Formula: 589-87-7)

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesHPLC of Formula: 589-87-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Abbasi, M. A.; Tariq, S.; Aziz-ur-Rehman; Siddiqui, S. Z.; Ahmad, I.; Malik, R.; Shah, S. A. A. published 《Synthesis of some new N-substituted-N-(2,3-dihydro-[1,4]benzodioxin-6-yl)-4-acetamidobenzenesulfonamides as valuable antibacterial agents》.Russian Journal of Bioorganic Chemistry published the findings.Name: 1,2-Diiodoethane The information in the text is summarized as follows:

The aim of the present research was to investigate the antibacterial potential of some N-substituted sulfonamides bearing a benzodioxane moiety, I (R = Et, iso-Pr, CH2Ph, 2-ClC6H4CH2, etc.). The synthesis was started by reacting N-2,3-dihydrobenzo[1,4]dioxin-6-amine with 4-acetamidobenzene-1-sulfonyl chloride in the presence of 10% aqueous Na2CO3 solution to yield N-(2,3-dihydrobenzo[1,4]-dioxin-6-yl)-4-acetamidobenzenesulfonamide (II). II was further reacted with alkyl/aralkyl halides in DMF and lithium hydride as a base to obtain products I. All the synthesized compounds were characterized by spectral data (IR, 1H NMR, EI-MS, and HR-MS). The compounds were tested for antibacterial activity and most of them exhibited potent therapeutic potential against various Gram-neg. and Gram-pos. strains. The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7Name: 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《The strength and directionality of a halogen bond are co-determined by the magnitude and size of the σ-hole [Erratum to document cited in CA160:690906]》 were Kolar, Michal; Hostas, Jiri; Hobza, Pavel. And the article was published in Physical Chemistry Chemical Physics in 2015. Application In Synthesis of 2-Fluoro-5-iodopyrimidine The author mentioned the following in the article:

Corrections are provided for the misuse of the term “”directionality””; the numerical results are unaffected. After reading the article, we found that the author used 2-Fluoro-5-iodopyrimidine(cas: 697300-79-1Application In Synthesis of 2-Fluoro-5-iodopyrimidine)

2-Fluoro-5-iodopyrimidine(cas: 697300-79-1) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application In Synthesis of 2-Fluoro-5-iodopyrimidine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis of 5-/8-Halogenated or Ethynylated Lipophilic Nucleobases as Potential Synthetic Intermediates for Supramolecular Chemistry》 were Bilbao, Nerea; Vazquez-Gonzalez, Violeta; Aranda, M. Teresa; Gonzalez-Rodriguez, David. And the article was published in European Journal of Organic Chemistry in 2015. Product Details of 3993-79-1 The author mentioned the following in the article:

A series of lipophilic nucleobases that are substituted at the 5- (pyrimidines) or 8- (purines) position with either a halogen atom or a terminal triple bond have been synthesized. The sequences and reactions studied in this work, which mainly comprise halogenation, alkylation, Sonogashira coupling, and trimethylsilylacetylene deprotection, have been carefully optimized, to reach the final compounds in the most straightforward and convenient way, with the highest possible purity and yield. These compounds include cytosine, isocytosine, and uracil derivatives as pyrimidine heterocycles, and guanine, isoguanine, and 2-aminoadenine derivatives as complementary purine bases. Variability was introduced at the N-1/N-9 positions of these pyrimidine/purine nucleobases, which were functionalized with alkyl or benzyl groups, as well as with protected amine or carboxylic acid substituents. The mols. prepared constitute a useful collection of synthetic intermediates for the field of chem. self-assembly. In the experimental materials used by the author, we found 2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1Product Details of 3993-79-1)

2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Product Details of 3993-79-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sakamoto, Takao; Kondo, Yoshinori; Watanabe, Ryo; Yamanaka, Hiroshi published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Condensed heteroaromatic ring systems. VII. Synthesis of thienopyridines, thienopyrimidines, and furopyridines from o-substituted N-heteroarylacetylenes》.COA of Formula: C6H6ClIN2 The author mentioned the following in the article:

Alkynylation of iodopyrimidines I (R = H, Me, Me2CH, MeS; R1 = H, Me, OMe; R2 = H) with Me3SiCCH gave 70-83% I (R2 = CCSiMe3), which were cyclized with NaSH to give 53-95% 8 thienopyrimidines II. In addition to this study using 4-Chloro-5-iodo-2,6-dimethylpyrimidine, there are many other studies that have used 4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6COA of Formula: C6H6ClIN2) was used in this study.

4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.COA of Formula: C6H6ClIN2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2015,Organic & Biomolecular Chemistry included an article by Camacho-Garcia, J.; Montoro-Garcia, C.; Lopez-Perez, A. M.; Bilbao, N.; Romero-Perez, S.; Gonzalez-Rodriguez, D.. Synthetic Route of C4H4IN3O. The article was titled 《Synthesis and complementary self-association of novel lipophilic π-conjugated nucleoside oligomers》. The information in the text is summarized as follows:

A series of lipophilic nucleosides comprising natural and non-natural bases that are π-conjugated to a short oligo-phenylene-ethynylene fragment has been synthesized. These bases comprise guanosine, isoguanosine, and 2-amino-adenosine as purine heterocycles, and cytidine, iso-cytosine and uridine as complementary pyrimidine bases. The hydrogen-bonding dimerization and association processes between complementary bases were also studied by 1H NMR and absorption spectroscopy in order to obtain the relevant association constants2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1Synthetic Route of C4H4IN3O) was used in this study.

2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Synthetic Route of C4H4IN3O

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 83410-16-6On October 25, 1982 ,《Studies on pyrimidine derivatives. XXX. The palladium-catalyzed cross-coupling reactions of iodopyrimidines with terminal olefinic compounds》 was published in Chemical & Pharmaceutical Bulletin. The article was written by Sakamoto, Takao; Arakida, Hiroko; Edo, Kiyoto; Yamanaka, Hiroshi. The article contains the following contents:

The influence of Ph3P, used as a ligand, on the palladium-catalyzed cross-coupling reactions of iodopyrimidines with olefins such as H2C:CHCO2Et, H2C:CHCN, H2C:CHPh was investigated. The effect of Ph3P in the monoazine series is also discussed. Thus, coupling of 2-iodo-4,6-dimethylpyrimidine with N2C:CHCO2Et in presence of Pd(OAc)2 gave 57% pyrimidine I. Using Pd(OAc)2-2Ph3P as a catalyst gave no I.4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6Recommanded Product: 83410-16-6) was used in this study.

4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 83410-16-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Computed Properties of C6H3ClINO2On September 30, 2019 ,《Sonogashira coupling reactions: Synthesis of 4-substituted-6-methyl-2-(methylthio)pyrimidines catalyzed by Pd-Cu》 was published in Journal of Chemical Research. The article was written by Rezaeimanesh, Fatemeh; Bakherad, Mohammad; Nasr-Isfahani, Hossein. The article contains the following contents:

An efficient method was developed for the synthesis of 4-(3-arylprop-2-ynyloxy)-6-methyl-2-(methylthio)pyrimidines via palladium-catalyzed Sonogashira reactions of 4-methyl-2-(methylthio)-6-(prop-2-yn-1-yloxy)pyrimidine with electron-poor aryl iodides in acetonitrile at room temperature Excellent yields of the products were obtained in reaction times of 9-11 h. In the part of experimental materials, we found many familiar compounds, such as 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Computed Properties of C6H3ClINO2)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Computed Properties of C6H3ClINO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2015,Mahamulkar, Shraddha G.; Cisarova, Ivana; Jahn, Ullrich published 《The Lithiation Reactivity and Selectivity of Differentially Branched Alkyldiphenylphosphine Oxides – A Simple and Versatile Approach to ortho-Functionalized Arylphosphine Oxides》.Advanced Synthesis & Catalysis published the findings.Synthetic Route of C2H4I2 The information in the text is summarized as follows:

Alkyldiphenylphosphine oxides typically undergo α-deprotonation with alkyllithium reagents. Here, the lithiation of differentially branched alkyldiphenylphosphine oxides was investigated and a diverse, but predictable reactivity was found. γ-Branched derivatives undergo selective directed ortho-metalation (DoM) using butyllithium and TMEDA as an additive. With decreasing degree of γ-branching α-lithiation becomes predominant. The ortho-phosphinoyllithium intermediates are subject to functionalization and C-C bond forming reactions, thus providing a convenient approach to new phosphine oxides and phosphine-borane complexes, which have a good potential for an approach to new ligands for catalysis. The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7Synthetic Route of C2H4I2)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Synthetic Route of C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com