Tag: 200-300

《Regio- and Stereoselective Synthesis of Ynenamides through Gold(I)-Catalyzed Hydroalkynylation of Ynamides》 was written by Siera, Hannah; Kreuzahler, Mathis; Wolper, Christoph; Haberhauer, Gebhard. Name: 4-IodobenzaldehydeThis research focused onynenamide preparation regioselective stereoselective DFT; gold catalyst ynamide hydroalkynylation. The article conveys some information:

Herein, regio- and stereoselective preparation of ynenamides I [R = Pr, cyclopropyl, Ph, etc.] via gold(I)-catalyzed hydroalkynylation of ynamides was exptl. shown. A wide range of products could be generated with yields up to 90% and, in contrast to many other gold-catalyzed alkyne dimerization reactions, alkyl groups were tolerated. Quantum chem. calculations and NMR labeling experiments revealed a mechanism via dual gold catalysis. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzaldehyde(cas: 15164-44-0Name: 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Name: 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 1,2-DiiodoethaneIn 2019 ,《Stable Cross-Conjugated Tetrathiophene Diradical》 was published in Angewandte Chemie, International Edition. The article was written by Zhang, Cheng; Medina Rivero, Samara; Liu, Wuyue; Casanova, David; Zhu, Xiaozhang; Casado, Juan. The article contains the following contents:

A tetracyano quinoidal tetrathiophene, having a central bi(thieno[3,4-c]pyrrole-4,6-dione) acceptor, has been studied. The recovered aromaticity of the thiophenes produces a diradical species with cross-conjugation between the inter-dicyano and inter-dione acceptor paths. A diradical character of y0=0.61 and a singlet-triplet gap of -2.76 kcal mol-1 were determined Competition between the two cross-conjugated paths enhances the disjointed character of the SOMOs and results in the confinement of the diradical to the mol. center, enabling a thermodn. diradical stabilization featuring a half-life of 262 h. Cross-conjugation effects have been also addressed in the anionic species (up to a radical trianion). In the experiment, the researchers used many compounds, for example, 1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C3H9IOSIn 2019 ,《Multifunctionalization of Indoles: Synthesis of 3-Iodo-2-sulfonyl Indoles》 was published in Bulletin of the Korean Chemical Society. The article was written by Park, Hyowon; Bae, Junryeol; Son, Soobin; Jang, Hye-Young. The article contains the following contents:

The selective multifunctionalization of indoles by using thiosulfonates, tri-Me sulfoxonium iodide (Me3SOI), and H2O2 was studied. The reaction of thiosulfonates with Me3SOI and H2O2 produced sulfonyl radicals and an iodination reagent, both of which were incorporated in indoles to form 3-iodo-2-sulfonyl indoles under carefully controlled conditions. The related reaction mechanism and the substrate scope of 3-iodo-2-sulfonyl indoles are presented. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6COA of Formula: C3H9IOS) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.COA of Formula: C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 624-73-7In 2017 ,《Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Niida, Ayumu; Sasaki, Shigekazu; Yonemori, Kazuko; Sameshima, Tomoya; Yaguchi, Masahiro; Asami, Taiji; Sakamoto, Kotaro; Kamaura, Masahiro. The article contains the following contents:

A structure-activity relationship study of a K-Ras(G12D) selective inhibitory cyclic peptide, KRpep-2d was performed. Alanine scanning of KRpep-2d focusing on the cyclic moiety showed that Leu7, Ile9, and Asp12 are the key elements for K-Ras(G12D) selective inhibition of KRpep-2d. The cysteine bridging was also examined to identify the stable analog of KRpep-2d under reductive conditions. As a result, the KRpep-2d analog (12) including mono-methylene bridging showed potent K-Ras(G12D) selective inhibition in both the presence and the absence of dithiothreitol. This means that mono-methylene bridging is an effective strategy to obtain a reduction-resistance analog of parent disulfide cyclic peptides. Peptide 12 inhibited proliferation of K-Ras(G12D)-driven cancer cells significantly. These results gave valuable information for further optimization of KRpep-2d to provide novel anti-cancer drug candidates targeting the K-Ras(G12D) mutant. In addition to this study using 1,2-Diiodoethane, there are many other studies that have used 1,2-Diiodoethane(cas: 624-73-7Application of 624-73-7) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Product Details of 516-12-1In 2019 ,《Constrained sialic acid donors enable selective synthesis of α-glycosides》 was published in Science (Washington, DC, United States). The article was written by Komura, Naoko; Kato, Keiichi; Udagawa, Taro; Asano, Sachi; Tanaka, Hide-Nori; Imamura, Akihiro; Ishida, Hideharu; Kiso, Makoto; Ando, Hiromune. The article contains the following contents:

Sialic acid is a sugar residue present in many biol. significant glycans of mammals, commonly as a terminal α-glycoside. The chem. structure of sialic acid, which features an anomeric center with carboxyl and methylene substituents, poses a challenge for synthesis of the α-glycoside, thus impeding biol. and therapeutic studies on sialic acid-containing glycans. We present a robust method for the selective α-glycosylation of sialic acid using macro-bicyclized sialic acid donors as synthetic equivalent of structurally constrained oxocarbenium ions to impart stereoselectivity. We demonstrate the power of our method by showcasing broad substrate scope and applicability in the preparation of diverse sialic acid-containing architectures. In addition to this study using 1-Iodopyrrolidine-2,5-dione, there are many other studies that have used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Product Details of 516-12-1) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Product Details of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 1-Iodo-4-methylbenzeneIn 2021 ,《Sensitive and Repeatable Photoinduced Luminescent Radicals from A Simple Organic Crystal》 was published in Angewandte Chemie, International Edition. The article was written by Mu, Yingxiao; Liu, Yanyan; Tian, Haiyan; Ou, Depei; Gong, Li; Zhao, Juan; Zhang, Yi; Huo, Yanping; Yang, Zhiyong; Chi, Zhenguo. The article contains the following contents:

Photoinduced organic radicals are important for chem. and phys. processes of organic materials, which are extensively investigated and applied in organic synthesis, photoelectronic devices and biotechnol. However, there are rare reports of the luminescence for these photoinduced radicals, especially in the condensed state. Herein, an unexpected and interesting luminescent radical is described, which can be rapidly and reversibly generated from a simple organic crystal by gentle light irradiation in air. It was revealed that the twist and asym. conformation of isolated mol. in its crystal with only weak C-H···π intermol. interactions, which led to the generation of such photoinduced luminescent radicals. In addition, dual-channel photosensitive device with rapid response and well repeatability can be obtained based on the thin film of this organic crystal, showing both photoswitching on luminescence and conducting. In the experiment, the researchers used many compounds, for example, 1-Iodo-4-methylbenzene(cas: 624-31-7Recommanded Product: 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Recommanded Product: 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 516-12-1In 2021 ,《Recent progresses in photocatalytic hydrogen production: design and construction of Ni-based cocatalysts》 appeared in International Journal of Energy Research. The author of the article were Liu, Xiaobin; Zhuang, Huaqiang. The article conveys some information:

A review. Up to now, much effort has focused on developing the highly efficiency composite photocatalysts by introducing cocatalysts in the photocatalytic hydrogen production reaction, because the proper cocatalysts can reduce activation energy, provide active sites, and suppress the reverse reaction. The transition metal nickel and its compounds acting as cocatalyst have received intensive attention because of their structural stability, facile preparation, and high performance in hydrogen evolution reaction, and are expected to replace the function of noble metals. This review emphasizes on the latest progresses that design and construction of composite photocatalyst using Ni-based cocatalyst for enhanced hydrogen production, such as metal nickel, nickel sulfide, and nickel phosphide, will be presented. Then, some preparation strategies and influence factors of Ni-based cocatalysts on enhanced photocatalytic hydrogen production are elucidated in detail. Finally, some challenge and perspective on the highly active cocatalysts in the area of photocatalytic hydrogen production from water splitting are also given. In the part of experimental materials, we found many familiar compounds, such as 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Application of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Application of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of C5H4INIn 2020 ,《A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy》 appeared in Analyst (Cambridge, United Kingdom). The author of the article were Wilson, Liam T.; Tipping, William J.; Jamieson, Lauren E.; Wetherill, Corinna; Henley, Zoe; Faulds, Karen; Graham, Duncan; Mackay, Simon P.; Tomkinson, Nicholas C. O.. The article conveys some information:

Intracellular pH (pHi) homeostasis is intertwined with a myriad of normal cellular behaviors as well as pathol. processes. As such, small mol. probes for the measurement of pHi are invaluable tools for chem. biol., facilitating the study of the role of pH in cellular function and disease. The field of small mol. pHi sensors has traditionally been dominated with probes based on fluorescent scaffolds. In this study, a series of low mol. weight (<260) oligoyne compounds have been developed which exhibit pH sensitive alkyne stretching frequencies (νalkyne) in Raman spectroscopy. The modular design of the compounds enabled tuneability of their pKa(H) through simple structural modification, such that continuous pH sensitivity is achieved over the range 2-10. Alkyne stretching bands reside in the ′cell-silent′ region of the Raman spectrum (1800-2600 cm-1) and are readily detectable in a cellular environment with subcellular spatial resolution This enabled the application of a pH sensitive oligoyne compound to the ratiometric sensing of pHi in prostate cancer (PC3) cells in response to drug treatment. We propose that probes based on Alkyne Tag Raman Imaging offer an entirely new platform for the sensing of pHi, complementary to fluorescence microscopy. In the experimental materials used by the author, we found 4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Synthetic Route of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Jia, Shiqi; Tian, Yuhong; Li, Xin; Wang, Pengfei; Lan, Yu; Yan, Hailong published an article in Angewandte Chemie, International Edition. The title of the article was 《Atroposelective Construction of Nine-Membered Carbonate-Bridged Biaryls》.Recommanded Product: 4-Chloro-2-iodoaniline The author mentioned the following in the article:

The authors herein demonstrate an efficient method for the atroposelective construction of nine-membered carbonate-bridged biaryls, e.g., I, through vinylidene ortho-quinone methide (VQM) intermediates. Diverse products with desirable pharmacol. features were synthesized in satisfying yields and good to excellent enantioselectivities. In subsequent bioassays, several agents showed considerable antiproliferative activity via the mitochondrial-related apoptosis mechanism. Further transformations produced more structural diversity and may inspire new ideas for developing functional mols. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7Recommanded Product: 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koothradan, Fathima Febin; Suresh Babu, Anusree; Pushpakaran, Krishnendu P.; Jayarani, Arumugam; Sivasankar, Chinnappan published an article in 2022. The article was titled 《Carboxylic Acid Functionalization Using Sulfoxonium Ylides as a Carbene Source》, and you may find the article in Journal of Organic Chemistry.Reference of 2-Iodobenzoic acid The information in the text is summarized as follows:

Functionalization of carboxylic acids using sulfoxonium ylides in the presence of [VO(acac)2] as a catalyst was reported. The usual carbene source, diazo compounds, failed to produce α-carbonyloxy esters I [R1 = Ph, 4-ClC6H4, 2-furyl, etc.; R2 = Me, Et, i-Pr, Bn; R3 = H, 2-Cl, 3-Cl, 4-Cl, 2-Br, 2-I] in good yield when compared to sulfoxonium ylides. Various standard spectroscopic and anal. techniques were used to characterize the products formed. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5Reference of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Reference of 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com