Tag: 200-300

The author of 《Palladium Catalyzed Regioselective C4-Arylation and Olefination of Indoles and Azaindoles》 were Thrimurtulu, Neetipalli; Dey, Arnab; Singh, Anurag; Pal, Kuntal; Maiti, Debabrata; Volla, Chandra M. R.. And the article was published in Advanced Synthesis & Catalysis in 2019. Formula: C7H7I The author mentioned the following in the article:

A convergent strategy for the synthesis of biol. relevant C4-substituted indole scaffolds was demonstrated using Pd(II)-catalyzed remote C-H functionalization of indoles and azaindoles. The reaction displayed high regioselectivity for the C4-position of indole-3-carbaldehydes using glycine as an inexpensive transient directing group. Notable features of this transformation included the selective formation of six-membered palladacyle and excellent functional group tolerance. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-4-methylbenzene(cas: 624-31-7Formula: C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Formula: C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Bioorganic & Medicinal Chemistry Letters included an article by Beck, Kasper; Reslow-Jacobsen, Charlotte; Hornum, Mick; Henriksen, Christian; Nielsen, Poul. Application of 1774-47-6. The article was titled 《A double-headed nucleotide with two cytosines: DNA with condensed information and improved duplex stability》. The information in the text is summarized as follows:

Double-headed nucleotide monomers are capable of condensing the genetic information of DNA. Herein, a double-headed nucleotide with two cytosine bases (CC) is constructed. The addnl. cytosine is connected through a methylene linker to the 2′-position of arabinocytidine. The nucleotide is incorporated into oligonucleotides and its effect on duplex stability is studied. For single incorporations, a thermal stabilization of 4.0 °C is found as compared to the unmodified duplex and it is shown that both nucleobases of CC participate in Watson-Crick base pairing. In combination with the previously published UT monomer, it is also shown that multiple incorporations are tolerated. For instance, a 16-mer sequence is targeted by a 13-mer oligonucleotide by using one CC and two UT monomers without compromising the overall duplex stability. Finally, the potential of double-headed nucleotides in triplex-forming oligonucleotides is studied, however, with the conclusion that the present design is not well-suited for this function.Trimethylsulfoxonium iodide(cas: 1774-47-6Application of 1774-47-6) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Application of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Applied Organometallic Chemistry included an article by Campisciano, Vincenzo; Calabrese, Carla; Liotta, Leonarda Francesca; La Parola, Valeria; Spinella, Alberto; Aprile, Carmela; Gruttadauria, Michelangelo; Giacalone, Francesco. Related Products of 591-18-4. The article was titled 《Templating effect of carbon nanoforms on highly cross-linked imidazolium network: Catalytic activity of the resulting hybrids with Pd nanoparticles》. The information in the text is summarized as follows:

Two different carbon nanoforms (CNFs), namely multi-walled carbon nanotubes (MWCNTs) and carbon nanohorns (CNHs), were chosen as support for the direct polymerization of a bis-vinylimidazolium salt. Transmission electron microscopy analyses revealed a templating effect of the CNFs on the growth of the polymeric network, which perfectly covers their whole surfaces creating a cylindrical or spherical coating for MWCNTs and CNHs, resp. Subsequently, the CNFs-polyimidazolium was used as stabilizers for Pd nanoparticles (Pd NPs), and the obtained materials were characterized by means of anal. and spectroscopic techniques and then employed as easily recoverable and recyclable catalysts for Suzuki and Heck reactions. Quant. conversions was obtained in almost all the explored reactions, even employing low loading of catalyst (down to 0.007 mol%). Suzuki reactions were carried out in pure water under aerobic conditions. Both materials showed excellent activity and recyclability for the investigated C-C coupling reactions, with the CNHs-based material resulting slightly more active than the MWCNTs-based one due to a higher superficial exposure of Pd NPs.1-Bromo-3-iodobenzene(cas: 591-18-4Related Products of 591-18-4) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Related Products of 591-18-4 Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of the Iranian Chemical Society included an article by Gaikwad, D. S.; Undale, K. A.; Patil, D. B.; Pore, D. M.. Safety of 1-Iodo-4-methylbenzene. The article was titled 《Multi-functionalized ionic liquid with in situ-generated palladium nanoparticles for Suzuki, Heck coupling reaction: a comparison with deep eutectic solvents》. The information in the text is summarized as follows:

A new catalytic system for Suzuki and Heck coupling for the synthesis of biaryls and olefins I [R = H, 4-OMe, 4-C(O)Me, etc.; R1 = Ph, CO2Me, CN, etc.] was developed from multi-functionalized task specific ionic liquid and in situ formed palladium nanoparticles(PdNPs). These PdNPs were found size below 10 nm and exhibited a excellent catalytic activity in the cross-coupling of aryl halide without using external phosphine ligand. Along with electron deficient olefins, electron rich olefins were also undergo smooth reaction giving excellent yield. The results obtained in ionic liquid were compared with results obtained in deep eutectic solvents. Progress of reaction was found very smooth in ionic liquid rather than in deep eutectic solvents. The aqueous system containing ionic liquid along with PdNPs was recycled for seven times, without any significant loss.1-Iodo-4-methylbenzene(cas: 624-31-7Safety of 1-Iodo-4-methylbenzene) was used in this study.

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Safety of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Fash, David M.; Peer, Cody J.; Li, Zhenwu; Talisman, Ian J.; Hayavi, Sima; Sulzmaier, Florian J.; Ramos, Joe W.; Sourbier, Carole; Neckers, Leonard; Figg, W. Douglas; Beutler, John A.; Chain, William J. published 《Synthesis of a stable and orally bioavailable englerin analogue》.Bioorganic & Medicinal Chemistry Letters published the findings.Quality Control of 1,2-Diiodoethane The information in the text is summarized as follows:

Synthesis of analogs of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound (I) which possessed the renal cancer cell selectivity of the parent and was orally bioavailable in mice.1,2-Diiodoethane(cas: 624-73-7Quality Control of 1,2-Diiodoethane) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bakherad, Mohammad; Bahramian, Bahram; Nasr-Isfahani, Hossein; Keivanloo, Ali; Doostmohammadi, Nesa published an article on January 31 ,2009. The article was titled 《Polystyrene-supported palladium(II) ethylenediamine complex: a highly active and recyclable catalyst for the synthesis of 2-benzylimidazo[2,1-b]pyridines through heteroannulation of acetylenic compounds》, and you may find the article in Journal of Heterocyclic Chemistry.HPLC of Formula: 41252-95-3 The information in the text is summarized as follows:

The polymer-supported palladium(II) ethylenediamine [PS-en-Pd(II)] complex is a highly active catalyst for the heterocyclization that takes place during the Sonogashira reaction between an aryl iodide and 2-amino-1-(2-propynyl)pyridinium bromide. This heterogeneous palladium catalyst can readily be recovered from the reaction medium by simple filtration and reused without a significant loss in its activity. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3HPLC of Formula: 41252-95-3)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.HPLC of Formula: 41252-95-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Strong Visible-Light-Absorbing Cuprous Sensitizers for Dramatically Boosting Photocatalysis》 was written by Chen, Kai-Kai; Guo, Song; Liu, Heyuan; Li, Xiyou; Zhang, Zhi-Ming; Lu, Tong-Bu. Category: iodides-buliding-blocksThis research focused onvisible light absorbing cuprous sensitizer photocatalyst; copper; light harvesting; oxidation; photocatalysis; photosensitizers. The article conveys some information:

Developing strong visible-light-absorbing (SVLA) earth-abundant photosensitizers (PSs) for significantly improving the utilization of solar energy is highly desirable, yet it remains a great challenge. Herein, we adopt a through-bond energy transfer (TBET) strategy by bridging boron dipyrromethene (Bodipy) and a CuI complex with an electronically conjugated bridge, resulting in the first SVLA CuI PSs (Cu-2 and Cu-3). Cu-3 has an extremely high molar extinction coefficient of 162 260 M-1 cm-1 at 518 nm, over 62 times higher than that of traditional CuI PS (Cu-1). The photooxidation activity of Cu-3 is much greater than that of Cu-1 and noble-metal PSs (Ru(bpy)32+ and Ir(ppy)3+) for both energy- and electron-transfer reactions. Femto- and nanosecond transient absorption and theor. investigations demonstrate that a “”ping-pong”” energy-transfer process in Cu-3 involving a forward singlet TBET from Bodipy to the CuI complex and a backward triplet-triplet energy transfer greatly contribute to the long-lived and Bodipy-localized triplet excited state. The results came from multiple reactions, including the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Category: iodides-buliding-blocks)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《An expedient route to tricyanovinylindoles and indolylmaleimides from o-alkynylanilines utilising DMSO as a one-carbon synthon》 was written by Chakraborty, Nikita; Dahiya, Anjali; Rakshit, Amitava; Modi, Anju; Patel, Bhisma K.. Electric Literature of C6H5ClINThis research focused ontricyanovinylindole preparation; alkynyl aniline malononitrile DMSO cascade palladium catalyst copper; indolylmaleimide preparation; phenyl indolyl ethene tricarbonitrile malononitrile cascade palladium catalyst copper. The article conveys some information:

A Pd(II)/Cu(II) catalyzed domino synthesis of tricyanovinylindoles I [R1 = H, 5-Me, 5-F, etc.; R2 = cyclopropyl, Ph, 2-naphthyl, etc.] was synthesized via reaction starting from o-alkynylanilines, malononitrile and utilizing DMSO as a one-carbon synthon. The reaction proceeded via the construction of 2-aryl-3-formyl indoles followed by sequential addition of malononitrile and a CN resulting in two C-C, one C=C and one C-N bonds in the final product. Furthermore, post-synthetic modification of some of the compounds I resulted in the unprecedented formation of 4-cyano-3-indolylmaleimides II [R3 = H, 5-Me, 5-Cl, etc.; R4 = H, 4-F, 4-tBu, etc.]. Photophys. studies of compoundsI [R1 = H, 5-CF3, 5-iPr; R2 = n-Bu, Ph, 4-MeC6H4, 4-F3CC6H4, 2-Br-5-FC6H3, 2-naphthyl] showed emission in the visible range. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Electric Literature of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Electric Literature of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 1-Iodopyrrolidine-2,5-dioneIn 2022 ,《N-Alkylated Analogues of Indolylthio Glycosides as Glycosyl Donors with Enhanced Activation Profile》 was published in European Journal of Organic Chemistry. The article was written by Shrestha, Ganesh; Panza, Matteo; Singh, Yashapal; Stine, Keith J.; Demchenko, Alexei V.. The article contains the following contents:

While studying indolylthio glycosides, previously we determined their activation profile that required large excess of activators. This drawback was partially addressed in the present study of N-alkylated indolylthio glycosides. Also investigated was orthogonality of the indolylthio leaving groups vs. thioglycosides and selective activation of thioimidates over oxindole glycosides. In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Recommanded Product: 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Recommanded Product: 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of C6H4BrIIn 2021 ,《Strong and Confined Acids Catalyze Asymmetric Intramolecular Hydroarylations of Unactivated Olefins with Indoles》 was published in Journal of the American Chemical Society. The article was written by Zhang, Pinglu; Tsuji, Nobuya; Ouyang, Jie; List, Benjamin. The article contains the following contents:

An efficient and highly enantioselective catalytic asym. intramol. hydroarylation of aliphatic and aromatic olefins with indoles e.g., 3-(4-methyleneoctyl)-1H-benzo[g]indole yielding tetrahydrocarbazoles e.g., I can be realized using strong and confined IDPi Bronsted acid catalysts. This unprecedented transformation is enabled by tertiary carbocation formation and establishes quaternary stereogenic centers in excellent enantioselectivity and with a broad substrate scope that includes an aliphatic iodide, an azide, and an alkyl boronate, which can be further elaborated into bioactive mols. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3-iodobenzene(cas: 591-18-4Electric Literature of C6H4BrI)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Electric Literature of C6H4BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com