Tag: 200-300

Wang, Xiaoshuang; Sun, Lei; Wang, Miaomiao; Maestri, Giovanni; Malacria, Max; Liu, Xiang; Wang, Yanlan; Wu, Lingang published an article in 2022. The article was titled 《C-I Selective Sonogashira and Heck Coupling Reactions Catalyzed by Aromatic Triangular Tri-palladium》, and you may find the article in European Journal of Organic Chemistry.Computed Properties of C6H4BrI The information in the text is summarized as follows:

Aromatic triangular tri-palladium cations, abbreviated as [Pd3]+, have shown interesting photoelec. properties, Lewis basic character, and excellent activities in catalytic hydrogenation. Herein, authors report the highly efficient and C-I selective Sonogashira and Heck coupling reactions catalyzed by these tri-palladium complexes. Benefiting from the moderate C-I bond association energy, these tri-palladiums presented exclusive reactivities to aryl iodides over the brominated aromatics in coupling reactions. In the Sonogashira pathway, good to excellent isolated yields (71-95%) were achieved. Gram-scale reaction reached 93% of yield with palladium loading as few as 0.06 mol %. Authors also explored the electronic and steric effects for Ph alkynes and aryl iodides including heteroaromatics like thiophene, pyridine, pyrazole, and pyrazine. Similarly, yields of 71-96% were obtained for palladium loading of 1.5 mol% through catalyzed Heck coupling of aryl iodides and alkenes. The HRMS monitoring revealed that [Pd3]+ maintained as whole entity during the catalytic process due to its robusness. In addition to this study using 1-Bromo-3-iodobenzene, there are many other studies that have used 1-Bromo-3-iodobenzene(cas: 591-18-4Computed Properties of C6H4BrI) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Computed Properties of C6H4BrI Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Arora, Ramon; Rodriguez, Jose F.; Whyte, Andrew; Lautens, Mark published an article in Angewandte Chemie, International Edition. The title of the article was 《Accessing Unsymmetrically Linked Heterocycles through Stereoselective Palladium-Catalyzed Domino Cyclization》.HPLC of Formula: 63069-48-7 The author mentioned the following in the article:

A palladium-catalyzed strategy is presented to synthesize unsym. linked heterocycles within stereoselective tetrasubstituted olefins I [R 1 = C6H5, 3-ClC6H4, 3-CH3C6H4, etc.; R2 = H, 5-Me, 5-Cl, 5-CF3, 6-C(O)2Me; R3 = Me, Bn, cyclohexylmethyl, etc.; R4 = Ph, 2-thienyl, cyclohexynyl, etc.; R5 = H, 6-Cl, 5-CN, 5-F, 5-CF3]. This reaction is proposed to occur via a vinyl-PdII intermediate capable of initiating the cyclization of various alkyne-tethered nucleophiles II (R6 = H, 5-Me, 5-Cl, 5-CF3, 5-C(O)2Me) and III (R7 = H, 5-Cl, 4-CN, 4-F, 4-CF3). Products I are formed in up to 96% yield with excellent stereoselectivities using low catalyst loadings. This transformation was scalable up to 1 mmol and mechanistic studies suggest a syn-carbopalladation of the carbamoyl chloride followed by PdII-catalyzed cyclization of alkyne-tethered nucleophiles. In addition to this study using 4-Chloro-2-iodoaniline, there are many other studies that have used 4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Kang, Do Hyung; Kim, Jinwoo; Eun, Han Jun; Kim, Sang Kyu published an article in Journal of the American Chemical Society. The title of the article was 《Experimental Observation of the Resonant Doorways to Anion Chemistry: Dynamic Role of Dipole-Bound Feshbach Resonances in Dissociative Electron Attachment》.Recommanded Product: 3-Iodophenol The author mentioned the following in the article:

Anion chem. dynamics of autodetachment and fragmentation mediated by the dipole-bound state (DBS) have been thoroughly investigated in a state-specific way by employing the picosecond time-resolved or the nanosecond frequency-resolved spectroscopy combined with the cryogenically cooled ion trap and velocity-map imaging techniques. For the ortho-, meta-, or para-iodophenoxide anion (o-, m-, or p-IPhO-), the C-I bond rupture occurs via the nonadiabatic transition from the DBS to the nearby valence-bound states (VBS) of the anion where the vibronic coupling into the S1 (πσ*) state (repulsive along the C-I bond extension coordinate) should be largely responsible. Dynamic details are governed by the isomer-specific nature of the potential energy surfaces in the vicinity of the DBS-VBS curve crossings, as manifested in the huge different chem. reactivity of o-, m-, or p-IPhO-. It is confirmed here that the C-I bond dissociation is mediated by DBS resonances, providing the foremost evidence that the metastable DBS plays the critical role as the doorway into the anion chem. especially of the dissociative electron attachment (DEA). The fragmentation channel is dominant when it is mediated by the DBS resonances located below the electron-affinity (EA) threshold, whereas it is kinetically adjusted by the competitive autodetachment when the DBS resonances above EA convey the electron to the valence orbitals. The product yield of the C-I bond cleavage is strongly mode-dependent as the rate of the concomitant autodetachment is much influenced by the characteristics of the individual vibrational modes, paving a new way of the reaction control of the anion chem. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8Recommanded Product: 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Recommanded Product: 3-Iodophenol In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Kitamura, Mitsuru; Eto, Takashi; Konai, Kazushige; Takahashi, Shuhei; Shimooka, Hirokazu; Okauchi, Tatsuo published an article in European Journal of Organic Chemistry. The title of the article was 《Synthesis of Diazoquinones and Azidophenols via Diazo-Transfer Reaction of Phenols》.Quality Control of 3-Iodophenol The author mentioned the following in the article:

The first efficient diazo-transfer reaction of phenols was described for the synthesis of o-quinone diazides (diazoquinones) from phenols in high yields using 2-azido-1,3-bis(2,6-diisopropylphenyl)imidazolium hexafluorophosphate (IPrAP, 2-PF6), which was a safe and stable crystalline The reaction efficiently proceeded in methanol in the presence of a base. Phenols substituted with electron-donating groups reacted more smoothly than those having electron withdrawing groups. Reactive phenols were diazotized by IPrAP with iPr2NH as a base, and low reactive phenols were diazotized with N,N-dimethyl-4-aminopyridine (DMAP). Furthermore, the formed diazoquinones reacted with sodium azide in 2-methoxyethanol and afforded the corresponding azidophenol in high yields.3-Iodophenol(cas: 626-02-8Quality Control of 3-Iodophenol) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Quality Control of 3-Iodophenol Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Guo, Zhonglin; Zhou, Pan; Song, Hongjian; Liu, Yuxiu; Zhang, Jingjing; Li, Yongqiang; Wang, Qingmin published an article in 2021. The article was titled 《Design, Synthesis, and Bioactivities of Phthalide and Coumarin Derivatives Based on the Biosynthesis and Structure Simplification of Gossypol》, and you may find the article in Journal of Agricultural and Food Chemistry.Name: 2-Iodobenzoic acid The information in the text is summarized as follows:

Because gossypol and hemigossypol show antiviral activity but are structurally complex, we designed and synthesized a series of structurally simpler phthalide and coumarin derivatives The phthalide derivatives were synthesized by opening the naphthalene ring of hemigossypol, and the coumarin derivatives were synthesized by ring-opening reactions of the phthalide derivatives with the goal of investigating the effect of the lactone ring size on bioactivity. The bioassay results showed that the two series of target compounds possessed moderate to good activities against tobacco mosaic virus, One of the compounds showed in vivo inactivation, curative, and protection activities of 50 ± 1, 53 ± 3, and 48 ± 2% at 500 mg/L, values which are higher than those of gossypol (32 ± 1, 35 ± 1, 29 ± 1%, resp.) and comparable to those of hemigossypol (55 ± 1, 49 ± 1, and 48 ± 1%, resp.) and the com. antiviral agent ningnanmycin (56 ± 2, 54 ± 1, 58 ± 1%) at the same dose. Thus, this compound is a promising candidate for the development of new anti-plant-virus agents. In addition, most of the synthesized compounds showed broad-spectrum activity when tested against 14 kinds of phytopathogenic fungi and showed selectivity against Sclerotinia sclerotiorum, Physalospora piricola, and Rhizoctonia cerealis. Moreover, some of the compounds exhibited activity against Plutella xylostella larvae; the two most active compounds exhibited larvicidal activities (LC50) of 4.10 and 5.47 mg/L, resp. Further studies showed that these compounds also exhibited insecticidal activities against Mythimna separata, Helicoverpa armigera, and Pyrausta nubilalis larvae. In addition to this study using 2-Iodobenzoic acid, there are many other studies that have used 2-Iodobenzoic acid(cas: 88-67-5Name: 2-Iodobenzoic acid) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides.Name: 2-Iodobenzoic acid The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qin, Yangzhong; Sun, Rui; Gianoulis, Nikolas P.; Nocera, Daniel G. published an article in 2021. The article was titled 《Photoredox Nickel-Catalyzed C-S Cross-Coupling: Mechanism, Kinetics, and Generalization》, and you may find the article in Journal of the American Chemical Society.Computed Properties of C7H7I The information in the text is summarized as follows:

Photoredox-mediated nickel-catalyzed cross-couplings have evolved as a new effective strategy to forge carbon-heteroatom bonds that are difficult to access with traditional methods. Exptl. mechanistic studies are challenging because these reactions involve multiple highly reactive intermediates and perplexing reaction pathways, engendering competing, but unverified, proposals for substrate conversions. Here, we report a comprehensive mechanistic study of photoredox nickel-catalyzed C-S cross-coupling based on time-resolved transient absorption spectroscopy, Stern-Volmer quenching, and quantum yield measurements. We have (i) discovered a self-sustained productive Ni(I/III) cycle leading to a quantum yield Φ > 1; (ii) found that pyridinium iodide, formed in situ, serves as the dominant quencher for the excited state photocatalyst and a critical redox mediator to facilitate the formation of the active Ni(I) catalyst; and (iii) observed critical intermediates and determined the rate constants associated with their reactivity. Not only do the findings reveal a complete reaction cycle for C-S cross-coupling, but the mechanistic insights have also allowed for the reaction efficiency to be optimized and the substrate scope to be expanded from aryl iodides to include aryl bromides, thus broadening the applicability of photoredox C-S cross-coupling chem. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-4-methylbenzene(cas: 624-31-7Computed Properties of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Computed Properties of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Salerno, Silvia; Amendola, Giorgio; Angeli, Andrea; Baglini, Emma; Barresi, Elisabetta; Marini, Anna Maria; Ravichandran, Rahul; Viviano, Monica; Castellano, Sabrina; Novellino, Ettore; Da Settimo, Federico; Supuran, Claudiu T.; Cosconati, Sandro; Taliani, Sabrina published an article in 2021. The article was titled 《Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of 1-Chloro-3-iodobenzene The information in the text is summarized as follows:

Synthesis of a set of new bicyclic tetrahydroindazoles featuring a secondary sulfonamide I [R1 = H, Me, C6H5; R2 = H, Me: R3 = H, 3-Me, 4-Cl, etc.] were described. Biol. evaluation of the inhibitory activity against the hCA I, II, IV, and IX isoforms allowed drawing a structure-activity relationship profile that was rationalized through theor. studies. The new mols. I into the single portions influencing the zinc chelation properties and the selectivity profile thereby which offerred a new platform for the discovery of new isotype selective CA inhibitors. In the part of experimental materials, we found many familiar compounds, such as 1-Chloro-3-iodobenzene(cas: 625-99-0Quality Control of 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides.Quality Control of 1-Chloro-3-iodobenzene The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Unnava, Ramanjaneyulu; Chahal, Kapil; Reddy, Kallu Rajender published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Synthesis of substituted 1,2-dihydroisoquinolines via Ni(II) and Cu(I)/Ag(I) catalyzed double nucleophilic addition of arylamines to ortho-alkynyl donor-acceptor cyclopropanes (o-ADACs)》.Synthetic Route of C3H9IOS The article contains the following contents:

A concise approach for the synthesis of substituted 1,2-dihydroisoquinolines via double nucleophilic addition of primary arylamines to ortho-alkynyl donor-acceptor cyclopropanes (o-ADACs) in the presence of a catalytic Ni(ClO4)2·6H2O and CuI/AgOTf system has been developed. Further applying this protocol, some of the derived malonates were converted into the corresponding monoesters under Krapcho decarboxylation reaction conditions. Thereafter, these esters were transformed into the resp. acids and alcs. In addition, multifunctionalized 4-(2,2,2-trifluoroacetyl) 1,2-dihydroisoquinolines were also obtained with excess TFAA. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Synthetic Route of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Synthetic Route of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tali, Javeed Ahmad; Singh, Davinder; Kumar, Gulshan; Shankar, Ravi published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Regioselective Base-controlled Pd-catalyzed Arylation of Imidazo[1,2-a]pyridines: leading selectivity at C8 position by N-chelation over O-chelation》.Safety of 4-Iodobenzaldehyde The article contains the following contents:

Herein, Pd/Ag2CO3 promoted C8 arylation of the heterocycles I (R = H, Me, Cl; R1 = H, Me, Cl; R2 = H; R3 = CHO) by overriding the N-chelation on O-chelation to form diarylimidazo[1,2-a]pyridine-carbaldehydes I (R2 = Ph, 3,4-dichlorophenyl, 4-formylphenyl, etc.; R3 = CHO) was reported. In this way, various examples have been synthesized in good to excellent yield. Furthermore, Pd/t-BuOK system has been developed for the novel deformylative C3 arylation of 2-aryl-imidazo[1,2-a]pyridines I to form diarylimidazo[1,2-a]pyridines I (R2 = H; R3 = Ph, 3,4-dichlorophenyl, 4-formylphenyl, etc.). The choice of the catalytic system is also demonstrated for heteroarylation. Both standardized protocols have been explored with broad substrate scope and good functional group tolerance. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzaldehyde(cas: 15164-44-0Safety of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Safety of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Nickel-Catalyzed 1,2-Diarylation of Alkenyl Carboxylates: A Gateway to 1,2,3-Trifunctionalized Building Blocks》 was written by Derosa, Joseph; Kang, Taeho; Tran, Van T.; Wisniewski, Steven R.; Karunananda, Malkanthi K.; Jankins, Tanner C.; Xu, Kane L.; Engle, Keary M.. Quality Control of 1-Iodo-4-methylbenzene And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

A nickel-catalyzed conjunctive cross-coupling of alkenyl carboxylic acids, aryl iodides, and aryl/alkenyl boronic esters is reported. The reaction delivers the desired 1,2-diarylated and 1,2-arylalkenylated products with excellent regiocontrol. To demonstrate the synthetic utility of the method, a representative product is prepared on gram scale and then diversified to eight 1,2,3-trifunctionalized building blocks using two-electron and one-electron logic. Using this method, three routes toward bioactive mols. are improved in terms of yield and/or step count. This method represents the first example of catalytic 1,2-diarylation of an alkene directed by a native carboxylate group. In the experiment, the researchers used many compounds, for example, 1-Iodo-4-methylbenzene(cas: 624-31-7Quality Control of 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Quality Control of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com