Tag: 200-300

Doi, Yasuhiro; Chiba, Junya; Morikawa, Tomoyuki; Inouye, Masahiko published an article in Journal of the American Chemical Society. The title of the article was 《Artificial DNA Made Exclusively of Nonnatural C-Nucleosides with Four Types of Nonnatural Bases》.Safety of 2-Amino-5-iodopyrimidin-4(1H)-one The author mentioned the following in the article:

A new class of DNA-like oligomers made exclusively of nonnatural, stable C-nucleosides is described. The nucleosides comprise four types of nonnatural bases attached to a deoxyribose through an acetylene bond with the β-configuration. The artificial DNA forms right-handed duplexes and triplexes with the complementary artificial DNA. The hybridization occurs spontaneously and sequence-selectively, and the resulting duplexes have thermal stabilities very close to those of natural duplexes. The artificial DNA might be applied to a future extracellular genetic system with information storage and amplifiable abilities. In addition to this study using 2-Amino-5-iodopyrimidin-4(1H)-one, there are many other studies that have used 2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1Safety of 2-Amino-5-iodopyrimidin-4(1H)-one) was used in this study.

2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of 2-Amino-5-iodopyrimidin-4(1H)-one

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-rich Substrates》 was written by Doobary, Sayad; Sedikides, Alexi T.; Caldora, Henry P.; Poole, Darren L.; Lennox, Alastair J. J.. HPLC of Formula: 624-31-7This research focused onvicinal difluoroalkane preparation difluorination unactivated alkene hypervalent iodine mediator; electrochem difluorination unactivated alkene hypervalent iodine mediator; electrochemistry; fluorination; green chemistry; hypervalent iodine; oxidation. The article conveys some information:

Fluorinated alkyl groups are important motifs in bioactive compounds, pos. influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their safety and scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochem. generation of a hypervalent iodine mediator using an “”ex-cell”” approach, which avoids oxidative substrate decomposition The more sustainable conditions give good to excellent yields in up to decagram scales. Of note, when handling HF reagents, personal protection is of utmost importance. In the experimental materials used by the author, we found 1-Iodo-4-methylbenzene(cas: 624-31-7HPLC of Formula: 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.HPLC of Formula: 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Direct Synthesis of Tri-/Difluoromethyl Ketones from Carboxylic Acids by Cross-Coupling with Acyloxyphosphonium Ions》 was written by Ispizua-Rodriguez, Xanath; Munoz, Socrates B.; Krishnamurti, Vinayak; Mathew, Thomas; Prakash, G. K. S.. Recommanded Product: 2-Iodobenzoic acidThis research focused ontrifluoromethyl ketone preparation chemoselective; carboxylic acid trifluoromethyltrimethylsilane cross coupling reaction; difluoromethyl ketone preparation chemoselective; dimethylpropyleneurea zinc difluoromethyl carboxylic acid cross coupling reaction; TMSCF3; acyloxyphosphonium; carboxylic acids; copper; difluoromethyl ketones; trifluoromethyl ketones. The article conveys some information:

A simple and straightforward approach to the synthesis of trifluoromethyl and difluoromethyl ketones RC(O)CF3 [R = naphth-2-yl, benzyl, (Z)-cycloundecen-2-yl, etc.] and RC(O)CF2H from widely available carboxylic acids RC(O)OH is disclosed. The transformation utilizes an acyloxyphosphonium ion as the active electrophile, conveniently generated in situ from the carboxylic acid substrate by using commodity chems. The utility of the reaction system is exemplified by its chemoselectivity, with tolerance to a variety of important functional groups. The late-stage functionalization of carboxylic acid active pharmaceutical ingredients and pharmaceutically relevant compounds is also discussed. The results came from multiple reactions, including the reaction of 2-Iodobenzoic acid(cas: 88-67-5Recommanded Product: 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Product Details of 90-14-2In 2019 ,《One-Pot and Reducible-Functional-Group-Tolerant Synthesis of α-Aryl- and α-Heteroaryl-α-Trifluoromethyl Alcohols via Tandem Trifluoroacetylation and MPV Type Reduction》 was published in European Journal of Organic Chemistry. The article was written by Funabiki, Kazumasa; Hayakawa, Ayaka; Kani, Ryunosuke; Inuzuka, Toshiyasu; Kubota, Yashuhiro. The article contains the following contents:

We have developed a new one-pot synthesis of α-aryl- and α-heteroaryl-α-trifluoromethyl alcs. carrying not only arenes with electron-withdrawing groups but also electron-deficient nitrogen-containing heteroarenes, which are of increasing interest because these compounds are some of the most important units in current fluorine-containing inhibitors or antagonists. This new method includes three tandem reactions in a one-pot synthesis: (1) the in situ generation of functionalized aromatic and electron-deficient heteroaromatic Grignard reagents, (2) trifluoroacetylation of the generated Grignard reagents with diphenylmethyl trifluoroacetate, and (3) successive Meerwein-Ponndorf-Verley type reduction It offers several advantages, including no need for expensive transition metals and gaseous trifluoromethylating reagents, toleration of not only reducible functional groups on the aryl groups but also electron-deficient nitrogen-containing heterocycles, easy scalability, and the ability to suppress the formation of the bis-aldol product as a byproduct by changing the ester moiety of the trifluoroacetate from an iso-Pr to a diphenylmethyl group. The results came from multiple reactions, including the reaction of 1-Iodonaphthalene(cas: 90-14-2Product Details of 90-14-2)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Product Details of 90-14-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of C5H4INIn 2019 ,《Dynamic Open Coordination Cage from Nonsymmetrical Imidazole-Pyridine Ditopic Ligands for Turn-On/Off Anion Binding》 appeared in Angewandte Chemie, International Edition. The author of the article were Ogata, Daiji; Yuasa, Junpei. The article conveys some information:

This work demonstrates a new nonconventional ligand design, imidazole/pyridine-based nonsym. ditopic ligands (1 and 1S), to construct a dynamic open coordination cage from nonsym. building blocks. Upon complex formation with Pd2+ at a 1:4 molar ratio, 1 and 1S initially form mononuclear PdL4 complexes (Pd2+(1)4 and Pd2+(1S)4) without formation of a cage. The PdL4 complexes undergo a stoichiometrically controlled structural transition to Pd2L4 open cages ((Pd2+)2(1)4 and (Pd2+)2(1S)4) capable of anion binding, leading to turn-on anion binding. The structural transitions between the Pd2L4 open cage and the PdL4 complex are reversible. Thus, stoichiometric addition (2 equiv) of free 1S to the (Pd2+)2(1S)4 open cage holding a guest anion ((Pd2+)2(1S)4·G-) enables the structural transition to the Pd2+(1S)4 complex, which does not have a cage and thus causes the release of the guest anion (Pd2+(1S)4+G-). In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Synthetic Route of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Chang, Fengwei; Wang, Chengyi; Chen, Qipeng; Zhang, Yongjin; Liu, Guohua published an article in Angewandte Chemie, International Edition. The title of the article was 《A Chemoenzymatic Cascade Combining a Hydration Catalyst with an Amine Dehydrogenase: Synthesis of Chiral Amines》.Category: iodides-buliding-blocks The author mentioned the following in the article:

An encapsulated Au/carbene combined with a free amine dehydrogenase as a co-catalyst system that enabled an efficient hydration/amination enantioselective cascade process to be accomplished was developed. The mechanistic investigation disclosed dual catalysis comprised of alkyne hydration, followed by a reductive amination process. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Diketopyrrolopyrrole-fullerene C60 architectures as highly efficient heavy atom-free photosensitizers: synthesis, photophysical properties and photodynamic activity》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Agazzi, Maximiliano L.; Almodovar, Vitor A. S.; Gsponer, Natalia S.; Bertolotti, Sonia; Tome, Augusto C.; Durantini, Edgardo N.. Synthetic Route of C7H5IO The article mentions the following:

Chromophore-fullerene C60 hybrids possess interesting properties that enable them to act as heavy atom-free photosensitizers and reactive oxygen species (ROS) producers. Here, two new diketopyrrolopyrrole-C60 conjugates were efficiently synthesized and characterized. The conjugates show broadband absorption in the visible spectral region, in which diketopyrrolopyrrole dyes act as light-harvesting antenna with very high capacity to populate excited triplet states. Furthermore, the ability of diketopyrrolopyrrole-C60 systems to generate singlet mol. oxygen was explored for the first time in solvents of different polarities. The exptl. results show that these architectures exhibit very high production rates of this ROS. In addition, a preliminary study on Staphylococcus aureus cell suspensions indicates that both conjugates exhibit phototoxicity after irradiation with green LED light. Thus, the data obtained provide evidence that these diketopyrrolopyrrole-C60 architectures act as potential heavy atom-free photosensitizers in photodynamic inactivation of microorganisms and other singlet oxygen-mediated applications. The experimental process involved the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Synthetic Route of C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Synthetic Route of C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《A novel magnetically recoverable palladium nanocatalyst containing organoselenium ligand for the synthesis of biaryls via Suzuki-Miyaura coupling reaction》 was published in Journal of Physics and Chemistry of Solids in 2020. These research results belong to Rangraz, Yalda; Nemati, Firouzeh; Elhampour, Ali. Electric Literature of C7H7I The article mentions the following:

In the present work, a novel heterogeneous catalytic system involving palladium(II) complex as moisture- and air-stable organoselenium ligand supported on Fe3O4 nanoparticles modified by SiO2/azidopropyltrimethoxy silane was designed, synthesized and characterized using various physicochem. methods inclusive of VSM, EDX, FE-SEM, TG, XRD, and FT-IR spectroscopy. The catalytic activity of the synthesized magnetic nanocatalyst which named Fe3O4@SiO2-T-Se/Pd(II) was evaluated in Suzuki-Miyaura coupling reactions for the preparation of corresponding biaryls RR1 (R = Ph, 1-naphthyl, 2-thiophenyl, etc.; R1 = Ph, 4-fluorophenyl, 4-methylphenyl) using diverse aryl halides RX (X = I, Br) and arylboronic acids R1B(OH)2. The mild reaction conditions, variety of substrate scope, good yield, low reaction time, high stability, utilization of organoselenium compound as an air and moisture insensitive ligand and its immobilization on solid support, and more importantly effortless recovery and recyclability of the catalyst up to seven consecutive runs with no remarkable change in its activity are some of the interesting features of this protocol that makes it more beneficial from both industrial and environmental points of view. After reading the article, we found that the author used 1-Iodo-4-methylbenzene(cas: 624-31-7Electric Literature of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Electric Literature of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Asian Journal of Organic Chemistry included an article by Padmavathi, Rayavarapu; Babu, Srinivasarao Arulananda. Synthetic Route of C7H7I. The article was titled 《Palladium-Catalyzed 8-Aminoquinoline-Aided sp2 δ-C-H Intramolecular Amidation/Annulation: A Route to Tricyclic Quinolones》. The information in the text is summarized as follows:

Systematic investigations of a Pd(II)-catalyzed, 8-aminoquinoline directing group (DG)-aided sp2 δ-C-H amidation (C-N bond formation) of different biaryl carboxamides were reported. Various biaryl carboxamides with suitably positioned sp2 δ-C-H bond with respect to the DG were assembled via β-C-H arylation and then they were subjected to Pd(II)-catalyzed sp2 δ-C-H intramol. amidation/annulation reactions. While the intramol. amidation of the sp2 δ-C-H bond of some carboxamides was not fruitful, several biaryl carboxamides underwent intramol. amidation of their sp2 δ-C-H bonds to afford various tricyclic quinolone motifs such as, phenanthridin-6(5H)-ones and thieno-/furo-/pyrrolo-[2,3-c]quinolin-4(5H)-ones. The assembly of the required biaryl carboxamides possessing the sp2 δ-C-H bond via the β-C-H arylation and the successive intramol. amidation (C-N bond formation) of the resulting biaryl carboxamides were also performed in one-pot reaction conditions to afford tricyclic quinolones. In addition to this study using 1-Iodo-4-methylbenzene, there are many other studies that have used 1-Iodo-4-methylbenzene(cas: 624-31-7Synthetic Route of C7H7I) was used in this study.

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Synthetic Route of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Research on Chemical Intermediates included an article by Nikpassand, Mohammad; Fekri, Leila Zare; Rahro, Parissa Naddaf. Reference of 4-Iodobenzaldehyde. The article was titled 《Catalyst-free grinding method: a new avenue for synthesis of 6-amino-3-methyl-4-aryl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile and DFT studies on the mechanistic pathway of this category of compounds》. The information in the text is summarized as follows:

An efficient, one-pot, catalyst-free grinding procedure for synthesis of 6-amino-3-methyl-4-aryl-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles I [X = H, 3-Cl, 4-OMe, etc.] was reported. The condensation of substituted benzaldehydes, 3-amino-5-methylpyrazole and malononitrile according to a three-component reaction was investigated using d. functional theory (DFT) at B3LYP/6-311G level to explore the reaction mechanism. All the routes were studied, the structure of the intermediates was optimized and all the resp. transition states were found. The results of the calculations showed that the proposed mechanism relies on four intermediates. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Reference of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Reference of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com