Tag: 200-300

In 2022,Zhang, Xing Xing; Diao, Liang Zhuo; Chen, Liu Zeng; Ma, Duo; Wang, Yu Meng; Jiang, Han; Ruan, Ban Feng; Liu, Xin Hua published an article in European Journal of Medicinal Chemistry. The title of the article was 《Discovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis》.Safety of 4-Iodobenzoic acid The author mentioned the following in the article:

A series of pterostilbene derivatives I [R1 = tert-Bu, Ph, 2-furyl, etc] were designed and synthesized based on previous SAR, leading to discovery of new effective NLRP3 inflammasome inhibitors with metabolic stability. Among them, the most effective compound I [R1 = 2-furyl] showed high inhibitory efficacy (against IL-1 β: IC50 = 1.23μM) and almost no toxicity (against IL-1 b: IC50 > 100μM). Further mechanism studies have showed that compound I [R1 = 2-furyl] directly targets the NLRP3 and affects the assembly of inflammasomes to inhibit the activation of NLRP3 inflammasomes. More importantly, in vitro experiments show that compound I [R1 = 2-furyl] has a significant therapeutic effect on DSS-induced colitis in mice with good metabolic stability to liver microsomes (t1/2 = 138.6 min). This research encourages the further development of more effective NLRP3 inflammasome inhibitors based on this chem. scaffold. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Safety of 4-Iodobenzoic acid) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Thakare, Milind S.; Pawar, Nilesh S.; Adole, Vishnu A.; Patil, Dipak B.; Patil, Vikas published an article in Journal of the Indian Chemical Society. The title of the article was 《Reactive sensing of gold (III) by coumarin tethered fluorescent probe through alkyne activation》.Product Details of 88-67-5 The author mentioned the following in the article:

A novel strategy, involving anchoring and un-anchoring of coumarin based fluorophore, has been established for the selective detection of Au3+ species. Selective sensing of Gold (Au3+) was triggered due to alkynophilicity of gold ions to create lateral fluorescence of a latent fluorophore. The 4-methyl-2-oxo-2H-chromen-7-yl 2-(2-phenylethynyl) benzoate (CEB) probe was synthesized by reacting 7-hydroxy-4-methylcoumarin with iodo-benzoic acid. CEB probe has an absorption at 300 nm and 335 nm which decreases gradually and new absorption appeared at 406 nm due to Au3+ promoted ester hydrolysis selectively over other metal ions with great sensitivity, which accompanies a turn on fluorescence change produced by 7-hydroxy coumarin. The principle behind this sensing strategy is activation of triple bond induced uniquely by Au+3 ions leading to cascade and delivers active fluorophore. The sensing mechanism was proposed and supported by 1H NMR, MS and TD-DFT experiments The d. functional theory (DFT) and time dependent d. functional theory (TD-DFT) theor. results of the CEB-probe and Au3+ reaction is in good agreement with the exptl. results. Addnl., probe could be well incorporated onto the test strips for effective detection of Au3+.2-Iodobenzoic acid(cas: 88-67-5Product Details of 88-67-5) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Product Details of 88-67-5 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Isbrandt, Eric S.; Nasim, Amrah; Zhao, Karen; Newman, Stephen G. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Catalytic Aldehyde and Alcohol Arylation Reactions Facilitated by a 1,5-Diaza-3,7-diphosphacyclooctane Ligand》.Related Products of 90-14-2 The article contains the following contents:

A catalytic method to access secondary alcs. by the coupling of aryl iodides was reported. Either aldehydes or alcs. can be used as reaction partners, making the transformation reductive or redox-neutral, resp. The reaction was mediated by a Ni catalyst and a 1,5-diaza-3,7-diphosphacyclooctane. This P2N2 ligand, which was previously been unrecognized in cross-coupling and related reactions, was found to avoid deleterious aryl halide reduction pathways that dominate with more traditional phosphines and NHCs. An interrupted carbonyl-Heck type mechanism was proposed to be operative, with a key 1,2-insertion step forging the new C-C bond and forming a nickel alkoxide that may be turned over by an alc. reductant. The same catalyst was also found to enable synthesis of ketone products from either aldehydes or alcs., demonstrating control over the oxidation state of both the starting materials and products. The results came from multiple reactions, including the reaction of 1-Iodonaphthalene(cas: 90-14-2Related Products of 90-14-2)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Related Products of 90-14-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Pendant Photochromic Conjugated Polymers Incorporating a Highly Functionalizable Thieno[3,4-b]thiophene Switching Motif》 were Peters, Garvin M.; Tovar, John D.. And the article was published in Journal of the American Chemical Society in 2019. SDS of cas: 624-73-7 The author mentioned the following in the article:

The ability to externally modulate conjugated polymer optoelectronic properties is an important challenge for modern organic electronics. One attractive approach entails the incorporation of stimuli-responsive mol. systems, such as diarylethenes, into polymeric materials. Our approach involves the design of polymers possessing photochromic moieties pendant to the main conjugated chain to allow for electronic influence along the polymer backbone while avoiding substantial conformational demands that may affect solid-state performance. Herein, we report the synthesis of a series of thieno[3,4-b]thiophene (TT)-based photochromes that demonstrate drastically different optoelectronic properties upon cyclization. Exptl. and computational investigations of aryl-extended model compounds provided crucial insight on the interplay between electronic structure and photochromic activity, thus allowing for the realization of pendant photoswitchable conjugated copolymers that reflect the activity found in the related model systems.1,2-Diiodoethane(cas: 624-73-7SDS of cas: 624-73-7) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.SDS of cas: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Orthogonal Nanoparticle Catalysis with Organogermanes》 were Fricke, Christoph; Sherborne, Grant J.; Funes-Ardoiz, Ignacio; Senol, Erdem; Guven, Sinem; Schoenebeck, Franziska. And the article was published in Angewandte Chemie, International Edition in 2019. Computed Properties of C7H7I The author mentioned the following in the article:

Although nanoparticles are widely used as catalysts, little is known about their potential ability to trigger privileged transformations as compared to homogeneous mol. or bulk heterogeneous catalysts. The authors herein demonstrate (and rationalize) that nanoparticles display orthogonal reactivity to mol. catalysts in the cross-coupling of aryl halides with aryl germanes. While the aryl germanes are unreactive in LnPd0/LnPdII catalysis and allow selective functionalization of established coupling partners in their presence, they display superior reactivity under Pd nanoparticle conditions, outcompeting established coupling partners (such as ArBPin and ArBMIDA) and allowing air-tolerant, base-free, and orthogonal access to valuable and challenging biaryl motifs. As opposed to the notoriously unstable polyfluoroaryl- and 2-pyridylboronic acids, the corresponding germanes are highly stable and readily coupled. The authors’ mechanistic and computational studies provide unambiguous support of nanoparticle catalysis and suggest that owing to the electron richness of aryl germanes, they preferentially react by electrophilic aromatic substitution, and in turn are preferentially activated by the more electrophilic nanoparticles. After reading the article, we found that the author used 1-Iodo-4-methylbenzene(cas: 624-31-7Computed Properties of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Computed Properties of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Biosynthesis of Pd/MnO2 nanocomposite using Solanum melongena plant extract and its application for the one-pot synthesis of 5-substituted 1H-tetrazoles from aryl halides》 were Nasrollahzadeh, Mahmoud; Ghorbannezhad, Fatemeh; Sajadi, S. Mohammad. And the article was published in Applied Organometallic Chemistry in 2019. Electric Literature of C5H4IN The author mentioned the following in the article:

In this work, for the first time, Solanum melongena plant extract was used for the green synthesis of Pd/MnO2 nanocomposite via reduction of Pd(II) ions to Pd(0) and their immobilization on the surface of manganese dioxide (MnO2) nanoparticles (NPs) as an effective support. The synthesized nanocomposite was characterized by various anal. techniques such as Fourier transform IR (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), field emission SEM (FESEM), energy dispersive X-ray spectroscopy (EDS), and UV-Vis spectroscopy. Pd/MnO2 nanocomposite was used as a heterogeneous catalyst for the one-pot synthesis of 5-substituted 1H-tetrazoles from aryl halides containing various electron-donating or electron-withdrawing groups in the presence of K4[Fe(CN)6] as non-toxic cyanide source and sodium azide. The products were obtained in good yields via a simple methodol. and easy work-up. The nanocatalyst can be recycled and reused several times with no remarkable loss of activity. The results came from multiple reactions, including the reaction of 4-Iodopyridine(cas: 15854-87-2Electric Literature of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Electric Literature of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Angewandte Chemie, International Edition included an article by Diehl, Claudia J.; Scattolin, Thomas; Englert, Ulli; Schoenebeck, Franziska. Synthetic Route of C6H4BrI. The article was titled 《C-I-Selective Cross-Coupling Enabled by a Cationic Palladium Trimer》. The information in the text is summarized as follows:

While there is a growing interest in harnessing synergistic effects of more than one metal in catalysis, relatively little is known beyond bimetallic systems. This report describes the straightforward access to an air-stable Pd trimer and presents unambiguous reactivity data of its privileged capability to differentiate C-I over C-Br bonds in C-C bond formations (arylation and alkylation) of polyhalogenated arenes, which typical Pd0 and PdI-PdI catalysts fail to deliver. Exptl. and computational reactivity data, including the first location of a transition state for bond activation by the trimer, are presented, supporting direct trimer reactivity to be feasible. In addition to this study using 1-Bromo-3-iodobenzene, there are many other studies that have used 1-Bromo-3-iodobenzene(cas: 591-18-4Synthetic Route of C6H4BrI) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Synthetic Route of C6H4BrI Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2015,Zhang, Wei; Dourado, Daniel F. A. R.; Mannervik, Bengt published 《Evolution of the active site of human glutathione transferase A2-2 for enhanced activity with dietary isothiocyanates》.Biochimica et Biophysica Acta, General Subjects published the findings.Quality Control of 1,2-Diiodoethane The information in the text is summarized as follows:

Organic isothiocyanates (ITCs) are produced by plants, in which they are released from glucosinolates by myrosinase. ITCs are generally toxic and serve as a chem. defense against herbivorous insects and against infections by microorganisms. In mammalian tissues subtoxic concentrations of ITCs can provide protective effects against cancer and other diseases partially by induction of glutathione transferases (GSTs) and other detoxication enzymes. Thus, human consumption of edible plants rich in ITCs is presumed to provide health benefits. ITCs react with intracellular glutathione to form dithiocarbamates, catalyzed by GSTs. Formation of glutathione conjugates is central to the biotransformation of ITCs and leads to a route for their excretion. Clearly, the emergence of ITC conjugating activity in GSTs is essential from the biol. and evolutionary perspective. In the present investigation an active-site-focused mutant library of GST A2-2 has been screened for enzyme variants with enhanced ITC activity. Significantly superior activities were found in 34 of the approx. 2000 mutants analyzed, and the majority of the superior GSTs featured His and Gly residues in one of the three active-site positions subjected to mutagenesis. We explored the propensity of GSTs to obtain altered substrate selectivity and moreover, identified a specific pattern of mutagenesis in GST for enhanced PEITC detoxification, which may play an important role in the evolution of adaptive responses in organisms subjected to ITCs. The facile acquisition of enhanced ITC activity demonstrates that this important detoxication function can be promoted by numerous evolutionary trajectories in sequence space. The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7Quality Control of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of 1-Bromo-3-iodobenzeneIn 2021 ,《Hypsochromic Shift of Multiple-Resonance-Induced Thermally Activated Delayed Fluorescence by Oxygen Atom Incorporation》 was published in Angewandte Chemie, International Edition. The article was written by Tanaka, Hiroyuki; Oda, Susumu; Ricci, Gaetano; Gotoh, Hajime; Tabata, Keita; Kawasumi, Ryosuke; Beljonne, David; Olivier, Yoann; Hatakeyama, Takuji. The article contains the following contents:

Herein, we reported an ultrapure blue multiple-resonance-induced thermally activated delayed fluorescence (MR-TADF) material (ν-DABNA-O-Me) with a high photoluminescence quantum yield and a large rate constant for reverse intersystem crossing. Because of restricted π-conjugation of the HOMO rather than the LUMO induced by oxygen atom incorporation, ν-DABNA-O-Me shows a hypsochromic shift compared to the parent MR-TADF material (ν-DABNA). An organic light-emitting diode based on this material exhibits an emission at 465 nm, with a small full-width at half-maximum of 23 nm and Commission Internationale de l’Eclairage coordinates of (0.13, 0.10), and a high maximum external quantum efficiency of 29.5%. Moreover, ν-DABNA-O-Me facilitates a drastically improved efficiency roll-off and a device lifetime compared to ν-DABNA, which demonstrates significant potential of the oxygen atom incorporation strategy. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-iodobenzene(cas: 591-18-4Quality Control of 1-Bromo-3-iodobenzene)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Quality Control of 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 1,2-DiiodoethaneIn 2018 ,《Radical Anions from Urea-type Carbonyls: Radical Cyclizations and Cyclization Cascades》 appeared in Angewandte Chemie, International Edition. The author of the article were Huang, Huan-Ming; McDouall, Joseph J. W.; Procter, David J.. The article conveys some information:

Radical anions generated from urea carbonyls by reductive electron transfer are exploited in carbon-carbon bond formation. New radical cyclizations of urea radical anions deliver complex nitrogen heterocycles and, depending upon the proton source used in the reactions, a chemoselective switch between reaction pathways can deliver two heterobicyclic scaffolds. A computational study has been used to investigate the selectivity of the urea radical processes. Furthermore, radical cyclization cascades involving urea radical anions deliver unusual spirocyclic aminal architectures. After reading the article, we found that the author used 1,2-Diiodoethane(cas: 624-73-7Reference of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Reference of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com