Tag: 200-300

Category: iodides-buliding-blocksIn 2019 ,《Synthesis and exploration of in-silico and in-vitro α-glucosidase and α-amylase inhibitory activities of N-(3-acetyl-2-methyl-4-phenylquinolin-6-yl)arylamides》 appeared in Journal of the Iranian Chemical Society. The author of the article were Kumar, L. Jyothish; Suresh, Y.; Rajasekaran, R.; Reddy, S. Rajeswara; Vijayakumar, V.. The article conveys some information:

Nitro function of 1-(2-methyl-6-nitro-4-phenylquinolin-3-yl)ethanone was converted into amine by grinding it with zinc dust and ammonium chloride which in turn successfully converted into the N-(3-acetyl-2-methyl-4-phenylquinolin-6-yl)arylamides I [R = H, 3-F, 2-O2N, etc.] by treating it with benzoic acids using coupling reagents such as EDC, HATU and DCC. The compounds I were found to afford excellent yields with HATU, moderate in EDC and very less in DCC and hence HATU was considered as a suitable coupling reagent. All the synthesized compounds I were evaluated for their in-silico and in-vitro α-glucosidase and α-amylase inhibitory activity using acarbose as standard to treat type II diabetes and all compounds showed pos. results by in-silico and in-vitro α-amylase inhibition assay. Among the tested compounds, compounds I [R = 2-I, 2-O2N] in α-glucosidase as well as in α-amylase were found to have least binding energy value and form more stable ligand-receptor complex. In addition, the compounds I [R = 2-I, 2-O2N] exhibited 56.90 ± 0.77% and 59.46 ± 0.61% of the higher potent α-glucosidase inhibitory activity with IC50 values 171.75 ± 3.95 μmol/mL and 171.67 ± 1.57 μmol/mL significantly (p < 0.05) compared to remaining seven test samples. And similarly, the compound I [R = 2-I, 2-O2N] possessed α-amylase inhibitory activity at a concentration of 100 μg/mL (55.42 ± 0.42% and 55.42 ± 1.14%) with IC50 values 138.92 ± 4.44 μmol/mL and 158.78 ± 2.34 μmol/mL. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Category: iodides-buliding-blocks)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Category: iodides-buliding-blocks Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Mansoor Al Sarraf, Ahmad Azhar; H. Alsultany, Forat; H. Mahmoud, Zaid; S. Shafik, Shafik; I. Al, Zuhair; Sajjadi, Ahmad published an article in Synthetic Communications. The title of the article was 《Magnetic nanoparticles supported zinc (II) complex (Fe3O4@SiO2-Imine/Thio-Zn(OAc)2): a green and efficient magnetically reusable zinc nanocatalyst for synthesis of nitriles via cyanation of aryl iodides》.Product Details of 15854-87-2 The author mentioned the following in the article:

Herein we introduce a novel and reusable nanomagnetic copper catalyst (Fe3O4@SiO2-Imine/Thio-Zn(OAc)2) constructed by immobilizing Zn (II) complex on the surface of magnetic nanoparticles functionalized with Imine/Thio group. The structure of the as-constructed Fe3O4@SiO2-Imine/Thio-Zn(OAc)2 nanomaterial was well analyzed by a number of spectroscopic techniques including: FT-IR, SEM, TEM, EDX, XRD, VSM, AAS and ICP-OES. Exptl. studies have well revealed that Fe3O4@SiO2-Imine/Thio-Zn(OAc)2 nanomaterial is an ecofriendly and efficient nanocatalyst for synthesis of synthesis of nitriles via cyanation of aryl iodides. The grafting of the zinc catalyst to the surface of magnetic nanoparticles has increased the catalytic activity of the material and also simplified catalyst recovery from the reaction mixture by an external magnet. The Fe3O4@SiO2-Imine/Thio-Zn(OAc)2 nanocatalyst was readily recovered by simple magnetic decantation and can be reused seven cycles without considerable loss in catalytic activity. In the experimental materials used by the author, we found 4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Sukowski, Verena; van Borselen, Manuela; Mathew, Simon; Fernandez-Ibanez, M. Angeles published an article in Angewandte Chemie, International Edition. The title of the article was 《S,O-Ligand Promoted meta-C-H Arylation of Anisole Derivatives via Palladium/Norbornene Catalysis》.Computed Properties of C6H4ClI The author mentioned the following in the article:

Here, a new catalytic system based on palladium/norbornene and an S,O-ligand for the meta-C-H arylation of aryl ethers that significantly outperforms previously reported systems has been developed. The unique ability of this system to employ alkoxyarene substrates bearing electron donating and withdrawing substituents is demonstrated. Addnl., ortho-substituted aryl ethers are well tolerated, overcoming the “”ortho constraint””, which is the necessity to have a meta-substituent on the alkoxyarene to achieve high reaction efficiency, by enlisting novel norbornene mediators. Remarkably, for the first time the monoarylation of alkoxyarenes is achieved efficiently enabling the subsequent introduction of a second, different aryl coupling partner to rapidly furnish unsym. terphenyls. Further insight into the reaction mechanism was achieved by isolation and characterization of some Pd-complexes-before and after meta C-H activation-prior to evaluation of their resp. catalytic activities. The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Computed Properties of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Computed Properties of C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hossain, Elius Md; Guo, Zhifang; Wang, Jun; Deacon, Glen B.; Junk, Peter C.; Diether, Dominic; Anwander, Reiner published an article in 2022. The article was titled 《η6-Arene(halogenidoaluminato)lanthanoid(III) Complexes: Synthesis, Characterization and Catalytic Activity for Isoprene Polymerization》, and you may find the article in European Journal of Inorganic Chemistry.Recommanded Product: 1,2-Diiodoethane The information in the text is summarized as follows:

η6-Arene(iodido-/bromido-aluminato)lanthanoid(III) complexes, [Ln(η6-C6H5Me)(AlI4)3] [Ln = La (1), Ce (2), Nd (3), (Gd) (4); C6H5Me = toluene], [Ln(η6-C6H3Me3-1,3,5)(AlI4)3] [Ln = La (5), Ce (6), Pr (7), Nd (8), Sm (9), Gd (10); C6H3Me3-1,3,5 = mesitylene], and [Ln(η6-C6H5Me)(AlBr4)3] [Ln = La (11), Nd (12), Sm (13)] were prepared by reactions of aluminum triiodide or aluminum tribromide with the corresponding lanthanoid metals and 1,2-diiodoethane or 1,2-dibromoethane in an arene (toluene or mesitylene) solution (molar ratio : 6 : 2 : 3). The first x-ray crystal structures of arene(iodidoaluminato)lanthanoid(III) complexes are reported. The lanthanoid atom is coordinated by an η6-arene and three chelating κ(I, I’)-tetraiodidoaluminato ligands. The tetrabromidoaluminate complexes have similar structures. The precatalyst 3 was treated with AlR3 (R = Me or iBu) to give [Nd(η6-C6H5Me)(AlI3R)3] species in situ, which were then tested for catalytic activity towards isoprene polymerization Although the resulting polyisoprene had a desirable high cis-1,4 content, the catalyst performance was well below known best performing systems and indicates that iodidoaluminates are the least favorable of the halogenidoaluminatolanthanoid(III) complexes. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Recommanded Product: 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Force, Guillaume; Perfetto, Anna; Mayer, Robert J.; Ciofini, Ilaria; Leboeuf, David published an article in 2021. The article was titled 《Macrolactonization Reactions Driven by a Pentafluorobenzoyl Group》, and you may find the article in Angewandte Chemie, International Edition.Related Products of 626-02-8 The information in the text is summarized as follows:

Macrolactones constitute a privileged class of natural and synthetic products with a broad range of applications in the fine chems. and pharmaceutical industry. Despite all the progress made towards their synthesis, notably from seco-acids, a macrolactonization promoter system that is effective, selective, flexible, readily available, and, insofar as possible, compatible with manifold functional groups is still lacking. Herein, we describe a strategy that relies on the formation of a mixed anhydride incorporating a pentafluorophenyl group which, due to its high electronic activation enables a convenient access to macrolactones, macrodiolides and esters with a broad versatility. Kinetic studies and DFT computations were performed to rationalize the reactivity of the pentafluorophenyl group in macrolactonization reactions. The experimental part of the paper was very detailed, including the reaction process of 3-Iodophenol(cas: 626-02-8Related Products of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Related Products of 626-02-8 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Punjajom, Kunlayanee; Tummatorn, Jumreang; Ruchirawat, Somsak; Thongsornkleeb, Charnsak published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《PdCl2-Catalyzed Oxidative Cyclization of N-(2′-Alkynylaryl)-1,3-ketoamides: Synthesis of 3,4-Diacyl-2-Quinolones》.Computed Properties of C6H5ClIN The article contains the following contents:

3,4-Diacyl-2-quinolone derivatives were prepared in a rapid manner starting from N-(2′-alkynylaryl)-1,3-ketoamide substrates. The reaction showcased a mild radical process mediated by ceric ammonium nitrate (CAN) in the presence of 5 mol% PdCl2 under basic conditions and was applicable to a wide range of substrates, giving 3,4-diacyl-2-quinolone products in up to 91% yield in over 40 examples. The reaction proceeded via the generation of a radical intermediate which could be trapped as a TEMPO-adduct that was isolated and fully characterized. The reported method provided a practical and scalable synthetic access to densely functionalized 3,4-diacyl-2-quinolone derivatives which would be suitable for further applications including medicinal and bioactivity evaluations as well as synthetic transformations. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Computed Properties of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Ruijng; Xiao, Bo; Li, Wenzuo; Li, Qingzhong published their research in International Journal of Quantum Chemistry in 2021. The article was titled 《Cooperative effects between triel and halogen bonds in complexes of pyridine derivatives: An opposite effect of the nitrogen oxidation on triel and halogen bonds》.Recommanded Product: 15854-87-2 The article contains the following contents:

Ab initio calculations are performed for binary complexes of TrR3···4-PyX/4-OPyX and 4-PyX/4-OPyX···N-base (Tr = B, Al; R = H, Cl, Br, I; X = Cl, Br, I; N-base = HCN, NHCH2, NH3). The halogen bond (XB) is weak but becomes stronger in the HCN(sp) < NH3(sp3) < NHCH2(sp2) pattern. Nitrogen oxidation can enhance the XB a little. The triel bond (TrB) is very strong, with interaction energy ranging from -35 to -58 kcal/mol. The TrB is weaker for the heavier halogen atom in the AlR3 complex, while no such dependence is found in the BR3 complex. The oxygen atom of 4-OPyX engages in a weaker TrB than the nitrogen atom of 4-PyX, inconsistent with the neg. mol. electrostatic potentials (MEPs) on both atoms. Both TrB and XB are strengthened in TrR3···4-PyX/4-PyOX···N-base. The binding distance of the stronger TrB is shortened to less than that of the weaker XB, which is in contrast to that in BF3···NCH···NCH, where the stronger TrB has a larger shortening in the binding distance. The cooperativity is explained by MEP and charge transfer. In the experiment, the researchers used 4-Iodopyridine(cas: 15854-87-2Recommanded Product: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Film-based fluorescence sensing: a “”chemical nose”” for nicotine》 were Liu, Ke; Zhang, Jing; Xu, Ling; Liu, Jing; Ding, Liping; Liu, Taihong; Fang, Yu. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Application of 589-87-7 The author mentioned the following in the article:

A novel series of emissive o-carborane derivatives, which showed multicolor, highly solid-state emission (ΦF ≥ 43%) and ideal photochem. stability, were synthesized. Inspired by the powerful mammalian olfactory system, the authors, for the first time, successfully obtained a fluorescent sensor array, which exhibits superior detection capability for nicotine in the gaseous phase (down to 3 ppb). Furthermore, the sensor array can be extended to detect nicotine in aqueous solution at the nano-gram level (∼0.1 ng cm-2) and determine the smoke of cigarette and electronic cigarette. In the experiment, the researchers used 1-Bromo-4-iodobenzene(cas: 589-87-7Application of 589-87-7)

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesApplication of 589-87-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Nanjing; Turpoff, Anthony; Zhang, Xiaoyan; Huang, Song; Liu, Yalei; Almstead, Neil; Njoroge, F. George; Gu, Zhengxian; Graci, Jason; Jung, Stephen P.; Pichardo, John; Colacino, Joseph; Lahser, Fred; Ingravallo, Paul; Weetall, Marla; Nomeir, Amin; Karp, Gary M. published an article on January 15 ,2016. The article was titled 《Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.COA of Formula: C4H2FIN2 The information in the text is summarized as follows:

A novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides was identified and optimized for activity against the HCV genotype 1b replicon resulting in compounds with potent and selective activity. Further evaluation of this series demonstrated potent activity across HCV genotypes 1a, 2a and 3a. Compound I had reduced activity against HCV genotype 1b replicons containing single mutations in the NS4B coding sequence (F98C and V105M) indicating that NS4B is the target. This novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides serves as a promising starting point for a pan-genotype HCV discovery program. After reading the article, we found that the author used 2-Fluoro-5-iodopyrimidine(cas: 697300-79-1COA of Formula: C4H2FIN2)

2-Fluoro-5-iodopyrimidine(cas: 697300-79-1) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.COA of Formula: C4H2FIN2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ivachtchenko, Alexandre; Golovina, Elena; Kadieva, Madina; Mitkin, Oleg; Tkachenko, Sergei; Okun, Ilya published their research in Bioorganic & Medicinal Chemistry on August 1 ,2013. The article was titled 《Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-HT6 receptors》.Quality Control of 1-Chloro-4-iodo-2-nitrobenzene The article contains the following contents:

Substituted di-Ph sulfones were synthesized, and the structures were confirmed by NMR, LC-MS and X-ray crystallog. Their antagonistic activities towards 5-HT6 receptor were assessed in a cell-based functional assay. Di-Ph sulfone, in spite of being the smallest and simplest known sulfonyl-containing 5-HT6R antagonist, showed a strong potency (Ki = 1.6 μM). Its derivative with a methylamine substituent, [N-methyl-2-(phenylsulfonyl)aniline], was ∼66-times as active as di-Ph sulfone (Ki = 24.3 nM). Addition of a piperazinyl moiety in the para-position relative to the sulfonyl group in N-methyl-2-(phenylsulfonyl)-5-piperazin-1-ylaniline led to a further 150-fold increase in potency (Ki = 0.16 nM) to block the serotonin-induced response of HEK-293 cells that were stably transfected with the human recombinant 5-HT6 receptor. In the experimental materials used by the author, we found 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Quality Control of 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Quality Control of 1-Chloro-4-iodo-2-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com