Tag: 200-300

In 2019,European Journal of Medicinal Chemistry included an article by Salah Ayoup, Mohammed; Wahby, Yasmin; Abdel-Hamid, Hamida; Ramadan, El Sayed; Teleb, Mohamed; Abu-Serie, Marwa M.; Noby, Ahmed. HPLC of Formula: 88-67-5. The article was titled 《Design, synthesis and biological evaluation of novel α-acyloxy carboxamides via Passerini reaction as caspase 3/7 activators》. The information in the text is summarized as follows:

In the current study, a new series of multifunctional Passerini products was synthesized and evaluated as potent caspase-dependent apoptotic inducers. The synthetic strategy adopted this isocyanide-based multicomponent reaction to possibly mimic the pharmacophoric features of various lead apoptotic inducers, where a series of α-acyloxy carboxamides I (R = C2H5, CH2C6H5, 4-ClC6H4, etc.) was prepared from p-nitrophenyl isonitrile, cyclohexanone and various carboxylic acids RCOOH. Accordingly, the main amide-based scaffold was decorated by substituents with varying nature and size to gain more information about structure-activity relationship. All the synthesized compounds were screened for cytotoxicity against normal human fibroblasts and their potential anticancer activities against three human cancer cell lines; MCF-7 (breast), NFS-60 (myeloid leukemia), and HepG-2 (liver) utilizing MTT assay. Among the most active compounds, I (R = 4-NO2C6H4, CH(OH)C6H5, CH2C6H5) were more potent and safer than doxorubicin with nanomolar IC50 values and promising selectivity indexes. Mechanistically, I (R = 4-NO2C6H4, CH(OH)C6H5, CH2C6H5) induced apoptosis by significant caspase activation in all the screened cancer cell lines utilizing flow cytometric anal. and caspase 3/7 activation assay. Again, I (R = 4-NO2C6H4, CH(OH)C6H5) recorded higher activation percentages than doxorubicin, while I (R = CH2C6H5) showed comparable results. Apoptosis-inducing factor1 (AIF1) quantification assay declared that I (R = 4-NO2C6H4, CH(OH)C6H5, CH2C6H5) didn’t mediate apoptosis through AIF1-dependent pathway (i.e. only by caspase activation). Physicochem. properties, pharmacokinetic profiles, ligand efficiency metrics and drug-likeness data of all the synthesized compounds were computationally predicted and showed that I (R = 4-NO2C6H4, CH(OH)C6H5, CH2C6H5) could be considered as drug-like candidates. Finally, selected compounds were preliminarily screened for possible antimicrobial activities searching for dual anticancer/antimicrobial agents as an advantageous approach for cancer therapy. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5HPLC of Formula: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF3》 was written by Phetcharawetch, Jongkonporn; Betterley, Nolan M.; Reutrakul, Vichai; Soorukram, Darunee; Leowanawat, Pawaret; Kuhakarn, Chutima. Application of 63069-48-7This research focused ontrifluoromethylthio indole preparation; alkynyl azidoarene silver trifluoromethanethiolate trifluoromethylthiolation. The article conveys some information:

Direct and effective trifluoromethylthiolation of 2-alkynyl azidoarenes 2-CCR-4-R1-5-R2C6H2N3 (R = n-Bu, Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R1 = H, Me, Cl, CF3, etc.; R2 = H, Cl) with silver(I) trifluoromethanethiolate (AgSCF3) has been developed for the construction of 3-((trifluoromethyl)thio)indoles I. The trifluoromethylthiolation protocol is compatible with a broad substrate scope, providing a variety of 3-((trifluoromethyl)thio)indoles in moderate to good yields within one step, open-air, and short reaction time. In addition to this study using 4-Chloro-2-iodoaniline, there are many other studies that have used 4-Chloro-2-iodoaniline(cas: 63069-48-7Application of 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Safety of 2-Iodobenzoic acidIn 2019 ,《Formation of Benzylic Iodides via a Nickel Catalyzed Diastereoselective Dearomative Carboiodination Reaction of Indoles》 was published in Angewandte Chemie, International Edition. The article was written by Marchese, Austin D.; Lind, Florian; Mahon, Aine E.; Yoon, Hyung; Lautens, Mark. The article contains the following contents:

A diastereoselective dearomative carboiodination reaction is reported. Herein, a novel metal-catalyzed approach for the preparation of reactive secondary benzylic iodides I (R1 = H, 8-Br, 9-Me, etc.; R2 = Me, Et, Ph, etc.; R3 = H, 2-OMe, 2-F) is reported. Utilizing the unique reactivity of nickel, the carboiodination reaction of non-activated aromatic double bonds provided a previously unattainable class of iodides. A broadly applicable method to avoid the use of a metallic reducing agent by utilizing an alkyl phosphite as the ligand has been discussed. The reaction is thought to proceed through a syn intramol. carbonickelation across 2-substituted indole, followed by a diastereoretentive reductive elimination of the carbon-iodine bond. The complex iodinated indolines generated in the reaction were obtained in moderate to good yields and good to excellent diastereoselectivity. The products were easily functionalized by a variety of synthetic methods. In the experiment, the researchers used many compounds, for example, 2-Iodobenzoic acid(cas: 88-67-5Safety of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Safety of 2-Iodobenzoic acid Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of C7H7IIn 2019 ,《Polymer-Supported Bis-1,2,4-triazolium Ionic Tag Framework for an Efficient Pd(0) Catalytic System in Biomass Derived γ-Valerolactone》 appeared in ACS Sustainable Chemistry & Engineering. The author of the article were Valentini, Federica; Mahmoudi, Hamed; Bivona, Lucia Anna; Piermatti, Oriana; Bagherzadeh, Mojtaba; Fusaro, Luca; Aprile, Carmela; Marrocchi, Assunta; Vaccaro, Luigi. The article conveys some information:

A resin-bound 1,2,4-triazolium ionic tag has been used as support for the preparation of solid palladium nanoparticles (Pd(0)-POLI-TAG-Pd). Owing to the pincer-type architecture of the triazolium ligand, the stabilization of a high amount of palladium nanoparticles (16 wt %) has been possible. The catalytic system has been fully characterized and used in low amounts (i.e., 0.1 mol % palladium loading) in representative Heck-Mizoroki cross-coupling processes. A negligible release of the metal was demonstrated, and a high activity was obtained over more runs. Besides, the protocol has been optimized for the use of safe biomass-derived γ-valerolactone reaction medium. In addition to this study using 1-Iodo-4-methylbenzene, there are many other studies that have used 1-Iodo-4-methylbenzene(cas: 624-31-7Synthetic Route of C7H7I) was used in this study.

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Synthetic Route of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Bouzriba, Chahrazed; Chavez Alvarez, Atziri Corin; Gagne-Boulet, Mathieu; Ouellette, Vincent; Lacroix, Jacques; Cote, Marie-France; C.-Gaudreault, Rene; Fortin, Sebastien published an article in European Journal of Medicinal Chemistry. The title of the article was 《Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation》.Safety of 3-Iodophenol The author mentioned the following in the article:

We recently discovered a new family of prodrugs deriving from Ph 4-(2-oxo-3-imidazolidin-1-yl)benzenesulfonates (PIB-SOs) bioactivatable by cytochrome P 450 1A1 (CYP1A1) into potent antimitotics referred to as Ph 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs). PAIB-SOs display significant selectivity toward human breast cancer cells based on the N-dealkylation of PAIB-SOs into their corresponding PIB-SOs by CYP1A1. In this study, we have evaluated the mol. mechanism of the bioactivation of PAIB-SOs into PIB-SOs by branching the linear alkyl chain on the imidazolidin-2-one (IMZ) moiety of PAIB-SOs by branched alkyl groups such as iso-Pr, iso-Bu and sec-Bu. Our results show that PAIB-SOs bearing an iso-Bu group on the IMZ moiety and either a methoxy, a chloro or a bromo group at positions 3, 3,5 or 3,4,5 on the aromatic ring B exhibit antiproliferative activity ranging from 0.13 to 6.9 μM and selectivity toward MCF7 and MDA-MB-468 mammary cancer cells comparatively to other cell lines tested. Moreover, the most potent and selective PAIB-SOs bearing an iso-Bu group and either a 3,5-Cl (44), 3,5-Br (45) or a 3,4,5-OMe (46) on the IMZ moiety exhibit antiproliferative activity in the sub-micromolar range and high selectivity ratios toward mammary cancer cells. They stop the cell cycle of MCF7 cells in the G2/M phase and disrupt their cytoskeleton. Furthermore, our studies evidenced that PAIB-SOs bearing either an iso-Pr, a sec-Bu or an iso-Bu group are hydroxylated on the carbon atom adjacent to the IMZ (Cα-OH) but only PAIB-SOs bearing an iso-Bu group are bioactivated into PIB-SOs. Finally, PAIB-SOs 45 and 46 exhibit low toxicity toward normal cells and chick embryos and are thus promising antimitotic prodrugs highly selective toward CYP1A1-expressing breast cancer cells. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Safety of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Mao, Shuai; Zhao, Yahao; Luo, Zixuan; Wang, Ruizhe; Yuan, Bo; Hu, Jianping; Hu, Linghao; Zhang, San-Qi; Ye, Xiaoxing; Wang, Mingliang; Chen, Zhengkai published an article in Frontiers in Chemistry (Lausanne, Switzerland). The title of the article was 《Metal-free photo-induced sulfidation of aryl iodide and other chalcogenation》.Quality Control of 4-Iodopyridine The author mentioned the following in the article:

A photo-induced C-S radical cross-coupling of aryl iodides and disulfides under transition-metal and external photosensitizer free conditions for the synthesis of aryl sulfides at room temperature has been presented, which features mild reaction conditions, broad substrate scope, high efficiency, and good functional group compatibility. The developed methodol. could be readily applied to forge C-S bond in the field of pharmaceutical and material science. The results came from multiple reactions, including the reaction of 4-Iodopyridine(cas: 15854-87-2Quality Control of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Quality Control of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wu, Dan; Hao, Wen-Juan; Rao, Qian; Lu, Yi; Tu, Shu-Jiang; Jiang, Bo published an article in 2021. The article was titled 《Engaging 1,7-diynes in a photocatalytic Kharasch-type addition/1,5-(SN”)-substitution cascade toward β-gem-dihalovinyl carbonyls》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).COA of Formula: C6H4ClI The information in the text is summarized as follows:

A new and general photocatalytic Kharasch-type addition/1,5-(SN”)-substitution cascade of 1,7-diynes with alkyl halides such as BrCCl3 and CBr4 was reported for the first time, and used to produce 65 hitherto unreported β-gem-dihalovinyl ketones/aldehydes with moderate to excellent yields in a highly regioselective manner. This reaction tolerates a wide scope of substrates, which offers a green and efficient entry to fabricate synthetically important β-gem-dihalovinyl carbonyl scaffolds. Notably, the late-stage application of these resulting β-gem-dihalovinyl carbonyls shows high and unique reactivity profiles and demonstrates the versatility of their derivatization. Thus, e.g., treatment of diyne I with CBrCl3 under blue irradiation in presence of fac-Ir(ppy)3 and NaOAc base in EtOH afforded II (80%). In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0COA of Formula: C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.COA of Formula: C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Tianyi; Zhao, Yonggang; Dong, Baojun; Li, Xiaogang published their research in Corrosion Engineering, Science and Technology in 2021. The article was titled 《Corrosion behaviour of 2205 DSS in the artificial industrial-marine environment》.HPLC of Formula: 516-12-1 The article contains the following contents:

The corrosion behavior of 2205 duplex stainless steel (2205 DSS) was investigated by atomization tests, which was performed in an S-bearing thin electrolyte layer used as the artificial industrial-marine environment. Electrochem. methods and XPS, were conducted to reveal the protection properties and the composition evolution of the passive film. The results indicated that the corrosion time would weak the protectiveness of passive film, which was attributed to the accumulation of defects and metal sulfides in the passive film. The decrease of composition percentage of Cr2O3 made more neg. effects on the protection properties of passive film than the increase of Cr(OH)3 and CrO3, whose formation was related to the adequate supply of oxygen and water mols. The metal sulfides such as NiS and MoS2 formed during atomization tests reduced the content of alloy oxides in the passive film, and provided locations for the growth of defects. In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1HPLC of Formula: 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. HPLC of Formula: 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Design of phosphorescent organic light emitting diodes (OLED) host materials based on carbazole: quantum chemistry study on carrier transport properties of oxazole derivatives》 were Li, Mingming. And the article was published in Journal of Nanoelectronics and Optoelectronics in 2019. Product Details of 591-18-4 The author mentioned the following in the article:

Organic Light Emitting Diodes (OLEDs), as lighting materials, have great application potential. Compared with fluorescent OLEDs, phosphorescent OLED devices can produce higher luminous efficiency, which is favored by many researchers. Among them, the key material of OLED is an important factor affecting the performance of this kind of device. In this study, the carbazole group and the 1,2,4-Triazole group with high hole transport properties were used as research materials, and four bipolar main materials of Triazole-carbazole group were prepared by mixed reaction under high temperature and catalyst conditions. One of the materials (4PTBB) was selected as carbazole derivative, and the D. Functional Theory (DFT) was introduced to study the carrier transport properties of the derivatives in quantum chem. During the experiment, the physicochem. properties of the four Triazole-carbazole bipolar host materials were analyzed. These new materials exhibited good thermal stability (Td: 418-448 degree), high glass transition temperature (Tg: 127-149 °C) and high triplet energy level (ET: 2.38 eV-2.78 eV); and the electron mobility of 4PTBB (5.77 x 10-2 cm2 · V-1 · s-1) was two orders of magnitude higher than hole mobility (5.89 x 10-4 cm2 · V-1 · s-1). The above results indicated that the Triazole-carbazole bipolar host material has good thermal stability and good electron transport performance, and it can be used for phosphorescent OLED devices to exhibit better performance. In the experimental materials used by the author, we found 1-Bromo-3-iodobenzene(cas: 591-18-4Product Details of 591-18-4)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Product Details of 591-18-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《MOF nano porous-supported C-S cross coupling through one-pot post-synthetic modification》 were Alinezhad, Heshmatollah; Ghasemi, Shahram; Cheraghian, Mansoureh. And the article was published in Journal of Organometallic Chemistry in 2019. Recommanded Product: 624-31-7 The author mentioned the following in the article:

UIO-66-NH2-Fu@Ni was synthesized by anchoring a mol. nickel furfural (Fu) complex into a functionalized nanoporous metal-organic framework (MOF) with the amine functional groups, using the one-pot post-synthetic modification. This new catalyst was identified via Fourier-transform IR (FT-IR) spectroscopy, proton-nuclear-magnetic-resonance (1HNMR) spectroscopy, nitrogen gas adsorption-desorption method, thermogravimetric analyses (TGA), energy-dispersive X-ray- mapping spectroscopy (EDX-MAP), field emission SEM (FE-SEM), and X-ray diffraction (XRD). 1HNMR anal. showed that around 16% of the amine functional groups of the nanocrystalline UIO-66-NH2 framework were modified with nickel complex. Also, according to the inductive couple plasma at. emission spectroscopy (ICP), around 2.98 w% of Ni was determined in the modified MOF. The Ni complex which was supported by UIO-66-NH2 nanocatalyst was effectively used as a heterogeneous catalyst for the formation of sulfur-containing mols. such as thioethers which are generally found in chem. biol., organic synthesis, and materials chem. through the C-S bond cross-coupling of aryl iodides with thiols. UIO-66-NH2-Fu@Ni propagated the condensation reaction by different aryl iodides and aryl thiols in moderate conditions in the presence of K2CO3 as a base in high reaction yield during 8-14 h. The Ni complex which was supported by UIO-66-NH2 nanocatalyst was simply recycled and reused thrice while its catalytic activity was maintained approx. In the experimental materials used by the author, we found 1-Iodo-4-methylbenzene(cas: 624-31-7Recommanded Product: 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Recommanded Product: 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com