Tag: 200-300

The author of 《Simple method for determining of the isokinetic temperature value for the SNAr reactions in solution》 were Vlasov, Vladislav M.. And the article was published in Journal of Physical Organic Chemistry in 2018. Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene The author mentioned the following in the article:

The changes of the free energy of activation δΔG≠exp and the activation entropy δΔS≠ in the framework of the isokinetic relationship δΔG≠exp vs. (Tiso – Texp) δΔS≠ were explored quant. to predict the isokinetic temperature Tiso for the aromatic nucleophilic substitution reactions in solution The experimental process involved the reaction of 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Gold (I/III)-Catalyzed Trifluoromethylthiolation and Trifluoromethylselenolation of Organohalides》 was written by Mudshinge, Sagar R.; Yang, Yuhao; Xu, Bo; Hammond, Gerald B.; Lu, Zhichao. Product Details of 626-02-8This research focused ontrifluoromethyl thioether preparation; silver trifluoromethanethiolate organohalide trifluoromethylthiolation gold redox catalyst; selenoether trifluoromethyl preparation; tetramethylammonium trifluoromethylselenate organohalide trifluoromethylselenolation gold redox catalyst; Cross-Coupling; Gold Catalysis; Organohalides; Trifluoromethylselenolation; Trifluoromethylthiolation. The article conveys some information:

The first C-SCF3/SeCF3 cross-coupling reactions using gold redox catalysis [(MeDalphos)AuCl], AgSCF3 or Me4NSeCF3, and organohalides ArI (Ar = Ph, 4-bromophenyl, 2,6-dimethoxypyridin-3-yl, ec.), (E/Z)-RCH=CHI (R = C(O)OMe, Ph, naphthalen-1-yl, etc.) and R1CCBr (R1 = Ph, 4-fluorophenyl, 4-nitrophenyl, etc.) as substrates are reported. The new methodol. enables a one-stop shop synthesis of aryl/alkenyl/alkynyl trifluoromethylthio- and selenoethers ArSCF3, (E/Z)-RCH=CHSCF3, R1CCSCF3, and RSeCF3 with a broad substrate scope (>60 examples with up to 97% isolated yield). The method is scalable, and its robustness is evidenced by the late-stage functionalization of various bioactive mols., which makes this reaction an attractive alternative in the synthesis of trifluoromethylthio- and selenoethers for pharmaceutical and agrochem. research and development. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8Product Details of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Product Details of 626-02-8 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2021 ,《Room-temperature phosphorescence of a water-soluble supramolecular organic framework》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Xu, Chen; Lin, Xiaohan; Wu, Wenjun; Ma, Xiang. The article contains the following contents:

A flexible porous water-soluble supramol. organic framework was developed, which could efficiently exhibit phosphorescence both in an aqueous phase and in a film state at room-temperature In the experiment, the researchers used 1-Bromo-4-iodobenzene(cas: 589-87-7Category: iodides-buliding-blocks)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..Category: iodides-buliding-blocks It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Iodination and iodo compounds. IV. Effect of substituents and solvent composition on the rate of aromatic iodination by the triiodine cation》 were Arotsky, Judah; Darby, A. Carl; Hamilton, John B. A.. And the article was published in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1973. Application of 41252-95-3 The author mentioned the following in the article:

The rate and products of the reaction of deactivated substituted benzenes (e.g., 4-ClC6H4CO2h) and I3+ in H2SO4 were studied. The rate constants were correlated by the electrophilic substituent constants σ+ to give the reaction constant ρ = -6.4. The kinetic isotope effect for the iodination of benzoic acid was kH/kD = 2. The rate of iodination increased as the proportion of H2O in the solvent increased. The results came from multiple reactions, including the reaction of 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Application of 41252-95-3)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Application of 41252-95-3 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tang, Shi; Ding, Shumin; Li, Dan; Li, Lianjie; Zhao, Haixia; Chai, Minxue; Wang, Jian published an article in 2021. The article was titled 《Palladium-catalysed imidoylative spirocyclization of 3-(2-isocyanoethyl)indoles》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Formula: C7H5IO The information in the text is summarized as follows:

A palladium-catalyzed construction of spiroindolines through dearomative spirocyclization of 3-(2-isocyanoethyl)indoles was developed. 2′-Aryl-, vinyl-, and alkyl-substituted spiroindolines were accessed under mild conditions with excellent functional group tolerance. C1-tethered oxindole- and indole-spiroindoline bisheterocycles were generated in high yields via alkene/allene insertion and an imidoylative spirocyclization cascade. Addnl., a tandem dearomatization of two different indoles was realized with N-(2-bromobenzoyl)indoles as the electrophilic coupling partner of 3-(2-isocyanoethyl)indoles, affording polyindoline – spiroindoline bisheterocyclic scaffolds conveniently. Under the catalysis of Pd(OAc)2 and a spinol-derived phosphoramidite ligand, chiral spiroindolines were successfully accessed with up to 95% yield and 85% ee. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzaldehyde(cas: 15164-44-0Formula: C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Formula: C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Enhancement of catalytic hydrogen evolution by NiS modification of ZnCo2O4 with cubic morphology》 was written by Mao, Min; Xu, Jing; Li, Jingjiao; Zhao, Sheng; Li, Xuanhao. Related Products of 516-12-1 And the article was included in Journal of Materials Science: Materials in Electronics in 2020. The article conveys some information:

A review. Abstract: It was the constant pursuit of researchers to explore catalysts with higher catalytic activity, and the use of co-catalysts to modify the performance of photocatalytic materials had a significant effect on charge separation In this paper, the non-precious metal NiS-modified ZnCo2O4 composite catalytic material prepared by hydrothermal method had high-efficiency catalytic performance. When the weight ratio of NiS to ZnCo2O4 was 12%, the optimal catalytic activity is 3.57 mmol g-1 h-1, which was more than twice that of ZnCo2O4. The presence of NiS not only improved the sp. surface area of the catalyst and its ability to respond to light, but the close interface formed by the combination of the two monomer phases accelerated the transfer and the utilization of the photocharge on ZnCo2O4 to NiS, thereby promoting the separation of electron holes and improving the photocatalytic activity of the catalyst. According to the research results, the mechanism of hydrogen production in the photocatalytic system was revealed. In this paper, NiS was used to modify the bimetallic oxide with cubic appearance, which provided a new strategy for the development of new photocatalysts. The experimental process involved the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Related Products of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Related Products of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of the American Chemical Society included an article by Bendelsmith, Andrew J.; Kim, Seohyun Chris; Wasa, Masayuki; Roche, Stephane P.; Jacobsen, Eric N.. Formula: C2H4I2. The article was titled 《Enantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond-Donor Catalysis》. The information in the text is summarized as follows:

Chiral-squaramide-catalyzed enantio- and diastereoselective synthesis of α-allyl amino esters is reported. The optimized protocol provides access to N-carbamoyl-protected amino esters via nucleophilic allylation of readily accessible α-chloro glycinates. A variety of useful α-allyl amino esters were prepared, including crotylated products bearing vicinal stereocenters that are inaccessible through enolate alkylation, with high enantioselectivity (up to 97% ee) and diastereoselectivity (>10:1). The reactions display 1st-order kinetic dependence on both the α-chloro glycinate and the nucleophile, consistent with rate-limiting C-C bond formation. Computational anal. of the uncatalyzed reaction predicts an energetically inaccessible iminium intermediate, and a lower energy concerted SN2 mechanism. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Formula: C2H4I2)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Formula: C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2015,Zhang, Hua; Wang, Caixia; Jiang, Tao; Guo, Haiming; Wang, Ge; Cai, Xinhua; Yang, Lin; Zhang, Yi; Yu, Haichuan; Wang, Hui; Jiang, Kai published 《Microtubule-Targetable Fluorescent Probe: Site-Specific Detection and Super-Resolution Imaging of Ultratrace Tubulin in Microtubules of Living Cancer Cells》.Analytical Chemistry (Washington, DC, United States) published the findings.Category: iodides-buliding-blocks The information in the text is summarized as follows:

Tubulins in microtubules have been recognized as potential targets in cancer chemotherapy for several years. However, their detection and imaging in living cells, especially following exposure to anticancer drugs, remains difficult to achieve. This difficulty is due to the very small cross section of microtubules and the very small changes in tubulin concentration involved. Photoswitchable fluorescent probes combined with the “”super-resolution”” fluorescence imaging technique present an exciting opportunity for site-specific detection and super-resolution imaging of specific microscopic populations, such as tubulin. A tubulin specific photoswitchable fluorescent probe (Tu-SP), that labels and detects ultratrace levels of tubulin in microtubules of living biosystems, was designed and evaluated. To realize super-resolution fluorescence imaging, the spiropyran derivative (SP), a classic photoswitch, was introduced to Tu-SP as a fluorophore. To detect ultratrace tubulin, Tu-SP employed the tubulin inhibitor, alkaloid colchicine (Tu), as a recognition unit. Tu-SP exhibited nearly nonintrinsic fluorescence before binding to tubulin, even if there were divalent metal ions and 375 nm lasers, resp. After binding to tubulin, a dramatic increase in fluorescence was detected within milliseconds when irradiated at 375 nm, this increase is a result of the transformation of Tu-SP into a colored merocyanine (Tu-SP-1) with fluorescence. Tu-SP was successfully used for site-specific imaging of tubulin at a resolution of 20 ± 5 nm in microtubules of living cancer cells. More importantly, the probe was suitable for site-specific and quant. detection of trace tubulin in microtubules of living biol. samples. After reading the article, we found that the author used 1,2-Diiodoethane(cas: 624-73-7Category: iodides-buliding-blocks)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis of novel 6-(substituted benzyl)imidazo[2,1-b][1,3]thiazole catalyzed by polystyrene-supported palladium(II) ethylenediamine complex》 was published in Journal of the Brazilian Chemical Society in 2009. These research results belong to Bakherad, Mohammad; Keivanloo, Ali; Bahramian, Bahram; Kamali, Taghi A.. Computed Properties of C6H3ClINO2 The article mentions the following:

Sonogashira coupling reaction of 2-amino-3-(2-propynyl)-1,3-thiazolium bromide with various aryl iodides RI (R = 2-O2NC6H4, 4-Cl-2-O2NC6H4, etc.) catalyzed by polymer-supported palladium(II) ethylenediamine complex, [PS-en-Pd(II)] gave the title compounds I. This heterogeneous palladium catalyst is efficient, stable, and recyclable. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Computed Properties of C6H3ClINO2)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Computed Properties of C6H3ClINO2Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Self-Assembly of a Giant Molecular Solomon Link from 30 Subcomponents》 was published in Angewandte Chemie, International Edition in 2014. These research results belong to Schouwey, Clement; Holstein, Julian J.; Scopelliti, Rosario; Zhurov, Konstantin O.; Nagornov, Konstantin O.; Tsybin, Yury O.; Smart, Oliver S.; Bricogne, Gerard; Severin, Kay. SDS of cas: 1008361-77-0 The article mentions the following:

The synthesis of topol. complex structures, such as links and knots, is one of the current challenges in supramol. chem. The so-called Solomon link consists of two doubly interlocked rings. Despite being a rather simple link from a topol. point of view, only few mol. versions of this link have been described so far. Here, the authors report the quant. synthesis of a giant mol. Solomon link from 30 subcomponents. The highly charged structure is formed by assembly of 12 cis-blocked Pt2+ complexes, six Cu+ ions, and 12 rigid N-donor ligands. Each of the two interlocked rings is composed of six repeating Pt(ligand) units, while the six Cu+ ions connect the two rings. With a mol. weight of nearly 12 kDa and a diameter of 44.2 Å, this complex is the largest non-DNA-based Solomon link described so far. Furthermore, it represents a mol. version of a “”stick link””. The experimental process involved the reaction of 3-Bromo-6-iodo-2-methylpyridine(cas: 1008361-77-0SDS of cas: 1008361-77-0)

3-Bromo-6-iodo-2-methylpyridine(cas: 1008361-77-0) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 1008361-77-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com