Tag: M.W=200-250

Wang, Wei published the artcileEnhancing Transition Dipole Moments of Heterocyclic Semiconductors via Rational Nitrogen-Substitution for Sensitive Near Infrared Detection, Formula: C6H13I, the publication is Advanced Materials (Weinheim, Germany) (2022), 34(28), 2201600, database is CAplus and MEDLINE.

Designing ultrastrong near-IR (NIR) absorbing organic semiconductors is a critical prerequisite for sensitive NIR thin film organic photodetectors (OPDs), especially in the region of beyond 900 nm, where the absorption coefficient of com. single crystalline silicon (c-Si) is below 10³ cm^-1. Herein, a pyrrolo[3,2-b]thieno[2,3-d]pyrrole heterocyclic core (named as BPPT) with strong electron-donating property and stretched geometry is developed. Relative to their analog Y6, BPPT-contained mols., BPPT-4F and BPPT-4Cl, show substantially upshifted and more delocalized highest occupied MOs, and larger transition dipole moments, leading to bathochromic and hyperchromic absorption spectra extending beyond 1000 nm with very large absorption coefficients (up to 3.7-4.3 x 10⁵ cm^-1) as thin films. These values are much higher than those (10⁴ to 1 x 10⁵ cm^-1) of typical organic semiconductors, and 1-2 orders higher than those of com. inorganic materials, such as c-Si, Ge, and InGaAs. The OPDs based on BPPT-4F or BPPT-4Cl blending polymer PBDB-T show high detectivity of above 10¹² Jones in a wide wavelength range of 310-1010 nm with excellent peak values of 1.3-2.2 x 10¹³ Jones, resp., which are comparable with and even better than those com. inorganic photodetectors.

Advanced Materials (Weinheim, Germany) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C18H14BrNO5S2, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iwasaki, Masayuki published the artcileRegioselective Synthesis of γ-Lactones by Iron-Catalyzed Radical Annulation of Alkenes with α-Halocarboxylic Acids and Their Derivatives, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Organic Letters (2018), 20(13), 3848-3852, database is CAplus and MEDLINE.

An abundant and low toxicity iron catalyst has enabled regioselective annulation of alkenes with α-halocarboxylic acids and their derivatives The reaction proceeds smoothly without any addnl. ligands, bases, and additives to afford a variety of γ-lactones in good yields. A proposed reaction pathway through radical annulation is supported by some mechanistic studies, involving radical clock and isotope labeling experiments The present method was applied to the practical iron-powder-promoted synthesis of γ-lactones.

Organic Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rodriguez-Muniz, Gemma M. published the artcileModulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols, HPLC of Formula: 638-45-9, the publication is Molecules (2022), 27(4), 1245, database is CAplus and MEDLINE.

Mitochondria-targeting drugs and diagnostics are used in the monitoring and treatment of mitochondrial pathologies. In this respect, a great number of functional compounds have been made mitotropic by covalently attaching the active moiety onto a triphenylphosphonium (TPP) cation. In this regard, luminol (probably the most widely known chemiluminescent mol.) has been employed for a number of biol. applications, including ROS detection. Hence, the photophys. interaction between the light-emitting species 3AP * and TPP cations needs to be evaluated, as it can add valuable information on the design of novel emission-based mitotropic systems. Author’s herein investigate the quenching effect of ethyltriphenylphosphonium cation onto substituted 3-aminophthalates. These were prepared in situ upon hydrolysis of the corresponding anhydrides, which were synthesized from 3-aminophthalimides. Steady-state fluorescence and time-resolved experiments were employed for the evaluation of a possible electron transfer quenching by phosphonium ions. A minor contribution of static quenching that was also detected is attributed to complex formation in the ground state. Accordingly, the chemiluminescence of luminol was indeed strongly reduced in the presence of phosphonium ions. Author’s results have to be taken into account during the design of new chemiluminescent mitotropic drugs or diagnostic agents of the luminol family.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khansole, Sandeep V. published the artcilePyridinium iodochloride, an efficient reagent for iodination of hydroxylated aromatic ketones and aldehydes, HPLC of Formula: 6443-90-9, the publication is Journal of the Chinese Chemical Society (Taipei, Taiwan) (2008), 55(4), 871-874, database is CAplus.

Direct iodination of several reactive aromatic compounds like hydroxy substituted acetophenones and aldehydes with pyridinium iodochloride proceeded smoothly to afford the corresponding aromatic iodides in good to excellent yield. Pyridinium iodochloride was an efficient solid iodinating reagent with no hazardous effect and it can be handled safely.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, HPLC of Formula: 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Larsen, A. A. published the artcileIodinated 3,5-diaminobenzoic acid derivatives, Recommanded Product: Pyridine Iodochloride complex, the publication is Journal of the American Chemical Society (1956), 3210-16, database is CAplus.

ICl (55 cc.) added to 120 g. KCl in 350 cc. H₂O and adjusted to 500 cc. gave a 2N KICl₂ solution (I). KIO₃ (71 g.), 40 g. KCl, and 5 cc. concentrated HCl in 80 cc. H₂O treated with stirring with 111 g. KI in 100 cc. H₂O and simultaneously with 170 cc. concentrated HCl, and the mixture adjusted to 500 cc. gave a 2N I. I (250 cc.) added with stirring to 45 cc. pyridine in 1 l. H₂O, the mixture adjusted to pH 5 with pyridine, and the crude precipitate air-dried (117 g.) and recrystallized from 700 cc. C₆H₆ gave 87 g. pyridine-ICl (II), light yellow solid, m. 135-6°. 3,5-(O₂N)₂C₆H₃CO₂H (212 g.) in 1.4 l. H₂O and 210 cc. concentrated NH₄OH heated with stirring to 70°, the mixture treated with a stream of H at such a rate as to keep the temperature at 75-80°, diluted with 800 cc. H₂O and 300 cc. concentrated HCl, cooled, and filtered, the filtrate adjusted to pH 3 with solid Na₂CO₃, and the orange precipitate recrystallized from 3.5 l. H₂O gave 160 g. 3,5-H₂N(O₂N)C₆H₃CO₂H (III), m. 211-13°. Na salt (78 g.) of III in 750 cc. H₂O treated at 40° with stirring with 43 cc. Ac₂O gave 80 g. N-Ac derivative of III, m. 291-5° (all m.ps. are corrected). Similarly were prepared: N-PrCO derivative, m. 243-5°, 76% yield; N-EtCO derivative (IV), m. 242-3°, 75%. III (91 g.) in 1.25 l. PhMe dried azeotropically, treated with 65 cc. iso-BuCOCl, refluxed 1.5 hrs., cooled, and filtered yielded 110 g. N-iso-Bu CO derivative of III, m. 223-4° (from EtOH). In the same manner were prepared the following N-acyl derivatives of III (acyl group, m.p. corrected, and % yield given): BuCO (V), 206-8°, 84; AmCO, 284-6°, 50; iso-AmCO, 206-7°, 82; C₆H₁₃CO, 170-1°, 62. III (100 g.) and 110 g. 70% HOCH₂CO₂H heated to 150°, the clear melt poured onto 3 l. crushed ice, and the precipitate reprecipitated from dilute aqueous NaOH with dilute HCl yielded 63 g. N-HOCH₂CO derivative of III, m. 231-3°. IV (98 g.) in 750 cc. H₂O dissolved at room temperature with NH₄OH, the solution hydrogenated 2 hrs. at room temperature and 500 lb. over Raney Ni and filtered, and the filtrate acidified with AcOH gave 63 g. 3,5-EtCONH(H₂N)C₆H₃CO₂H, m. 206-8°. Similarly were prepared the following 3-acylamino-5-aminobenzoic acids (VI) (acylamino group, m.p. corrected, and % yield given): PrCO, 237-8°, 75; HOCH₂CO, 204-7°, 85°. V (112 g.) in 750 cc. H₂O and 77 cc. N₂H₄.H₂O treated with 12 g. Raney Ni in 6 portions, and the mixture heated on the steam bath until foaming stopped and worked up yielded 86 g. 3,5-H₂N(BuCONH)C₆H₃CO₂H, m. 230-1° (from EtOH). Similarly were prepared the following VI (acyl group, m.p. corrected, and % yield given): Ac (VII), 222-4°, 97; iso-BuCO, 242-4°, 67; AmCO, 203-4°, 80; iso-AmCO, 224-5°, 61; C₆H₁₃CO, 183-5°, 65. VII (38.8 g.) in 1 l. H₂O and 16 cc. concentrated HCl treated dropwise during 20 min. with 210 cc. I, the mixture stirred 3 hrs., the gray solid (86 g.) filtered off, washed with H₂O, dissolved in 1 l. H₂O with NH₄OH, treated with 5 g. NaHSO₃, and acidified with 6N HCl, and the precipitate dissolved in dilute NH₄OH, charcoaled, and reprecipitated yielded 57 g. 3,5,2,6-AcNH(H₂N)I₂C₆HCO₂H (VIII), m. 215-17° (decomposition); LD₅₀ intravenous in mice 9.5 ± 0.5 g./kg. (these values are given throughout the further abstract in parentheses). In the same manner were prepared the following 3-acylamino analogs of VIII (acyl group, m.p. corrected, and % yield given): EtCO, 210-12°, 41 (10.0); PrCO (IX), 204-5°, 40 (6.94), HOCH₂CO (X), 225-7°, 40 (7.35). VIII (100 g.), 900 cc. Ac₂O, and 2 cc. concentrated H₂SO₄ heated 3 hrs. on the steam bath, the solution poured onto 3 kg. ice, allowed to stand some time, and filtered, and the residue air-dried (102 g.) and reprecipitated with acid from dilute aqueous NaOH gave 85 g. 3,5,2,6-(AcNH)₂I₂C₆HCO₂H (XI), which recrystallized from 1.5 l. EtOH and reprecipitated from the NH₄ salt gave pure XI, white solid, m. 266-8° (decomposition) (9.80 ± 0.8). Similarly were prepared the following compounds (same data given): 3,5,2,6-EtCONH(AcNH)I₂C₆HCO₂H (XII), 241-2° (from HCONMe₂), 33 (12.66); 3-AcOCH₂CONH analog of XII, 238-9° (from AcOH), 50 (8.5). VIII (33 g.), 145 cc. (PrCO)₂O, and 10 drops concentrated H₂SO₄ heated 2.5 hrs. on the steam bath, cooled, and filtered, and the residue washed with pentane and purified in the usual manner gave 16 g. 3-PrCONH analog (XIII) of XII, m. 220-1° (decomposition) (from Me₂CO) (13.00). 3,5,2,6-AcNH(AcOCH₂CONH)I₂C₆HCO₂H (23 g.) in H₂O treated gradually with 84 cc. N aqueous NaOH, filtered, and acidified gave 13 g. 3,5,2,6-HOCH₂CONH(AcNH)I₂C₆HCO₂H, white solid, m. 223-5° (decomposition) (from EtOH) (>3.6). VII (97 g.) in 2.5 l. H₂O treated with stirring during 0.5 hr. with 550 cc. I, the mixture stirred 3 hrs. at room temperature, neutralized with 155 cc. 35% aqueous NaOH, treated during 0.5 hr. with an addnl. 250 cc. I, and filtered, the residue washed with H₂O, air-dried, heated to 90° with 400 cc. saturated aqueous NH₄Cl, made ammoniacal, filtered, and cooled, the precipitated NH₄ salt dried, dissolved in 3 l. hot H₂O, and charcoaled, and the product precipitated with concentrated HCl gave 220 g. 4-iodo derivative (XIV) of VIII, white solid, m. 258-9° (decomposition) (from EtOH) (7.20 ± 0.66). Similarly were prepared the 4-iodo derivatives (m.p. and % yield given) of the following compounds: BuCONH analog of IX, 236-7° (from aqueous EtOH), 50 (5.66); X, 263-4° (from aqueous EtOH), 71 (4.32). XIV (28.6 g.) and 70 cc. iso-PrCOCl heated 4 hrs. on the steam bath, cooled, and filtered, and the residue purified in the usual manner gave 27 g. 3,5,2,4,6-AcNH(iso-PrCONH)I₃C₆CO₂H (XV), m. above 300° (from dilute EtOH) (6.87). Similarly were prepared the following 5-acylamino analogs of XV (acyl group, m.p. corrected, and % yield given): BuCO, 290-3°, 47 (6.20 ± 0.40); iso-BuCO, above 290°, 40 (3.12); AmCO, 276-8°, 60 (3.20 ± 0.16); iso-AmCO, 291-2°, 45 (2.38); C₆H₁₃CO, 294-5°, 79 (1.32 ± 0.84); C₇H₁₅CO, 278-9°, 60 (0.48 ± 0.03) (all recrystallized from aqueous EtOH). 3,5-(O₂N)₂C₆H₃CO₂H (212 g.) in 1.4 l. H₂O and 168 cc. concentrated HCl hydrogenated 0.5 hr. over 30 g. 10% Pd-C at 1500 lb. initial pressure and filtered, the filtrate diluted to 12 l. with H₂O, the solution treated with 1.6 l. I, the mixture stirred 0.5 hr. and filtered, and the residue washed and air-dried gave 475 g. crude product; 53 g. crude product and 100 cc. saturated aqueous NH₄Cl heated on the steam bath, treated with NH₄OH, and filtered, the filtrate cooled to 0°, the crystalline deposit dissolved in H₂O and treated 2 hrs. in the cold with C, and the product precipitated with AcOH yielded 42 g. 3,5,2,4,6-(H₂N)₂I₃C₆CO₂H (XVI), dull white solid, m. 154-8° (decomposition) (1.31 ± 0.13). HCO₂H (98%) (610 cc.) added as rapidly as possible below 15° with stirring to 400 cc. cold Ac₂O, the mixture treated with 53 g. XVI, warmed slowly to 50°, kept 1 hr. at 50-5°, diluted with 250 cc. H₂O, and allowed to stand overnight, the gray solid deposit washed with warm H₂O, air-dried (47 g.), suspended in 400 cc. 70% iso-PrOH and dissolved at the boiling point with 5% aqueous NaOH, the solution decolorized with C and cooled, and the resulting Na salt (34 g.) dissolved in H₂O and acidified with dilute HCl yielded 28 g. 3,5,2,4,6-(HCONH)₂I₃C₆CO₂H (XVII), m. above 300° (7.40 ± 0.44). Similarly was prepared the 3-AcNH analog of XVII, m. 261-2° (from dilute EtOH), 40% (10.8 ± 0.46). XVI (145 g.) in 750 cc. Ac₂O dissolved at 70-5°, cooled to 45-50°, treated with 10 drops concentrated H₂SO₄, heated 15 min. on the steam bath, and cooled, and the resulting crude product (137 g.) purified in the usual manner through the NH₄ salt gave 130 g. di-Ac derivative (XVIII) of XVI, white solid, m. above 300° (from 50% aqueous HCONMe₂) (13.40 ± 0.86). Similarly were prepared the following diacyl derivatives of XVI (acyl group or groups, m.p. corrected, and % yield given): EtCO, Ac, above 300°, 77 (10.0 ± 0.57); PrCO, Ac, above 300, 65 (8.70 ± 0.44); HOCH₂CO, Ac, 249-51° (from H₂O), 50 (8.50 ± 0.70); AcOCH₂CO, Ac, 284-9° (from AcOH), 55 (8.50 ± 0.74); EtCO, above 300° (from aqueous HCONMe₂), 59 (11.80 ± 0.54); PrCO, above 300° (from EtOH), 33, 7.20 ± 0.58; BuCO, above 300° (from aqueous MeOH), 33 (2.65 ± 0.18); iso-BuCO, above 300° (from aqueous MeOH), 45 (3.57); AmCO, above 300° (from aqueous MeOH), 35 (0.60 ± 0.06). 3,6-H₂N(O₂N)C₆H₃CO₂H (24 g.) and 70 g. II in 1 l. H₂O stirred 6 hrs. at room temperature, 6 hrs. on the steam bath, cooled, treated with excess NH₄OH, and filtered, the filtrate heated on the steam bath, acidified with dilute HCl, and filtered, the precipitate washed and air-dried (45.3 g.) and heated 0.5 hr. on the steam bath with 125 cc. Ac₂O and 10 drops concentrated H₂SO₄, the mixture treated cautiously with hot H₂O, and the solution kept at room temperature overnight gave 43.6 g. 3,6,2,4-AcNH(O₂N)I₂C₆HCO₂H (XIX), m. 266-7° (decomposition). XIX (9 g.) in 50 cc. H₂O and 8 cc. concentrated NH₄OH treated with 15 g. Na₂S₂O₄ at 15-20°, the solution heated 10 min. on the steam bath, cooled, adjusted with NH₄OH to pH 8-9, treated with Filer-Cel, and filtered, and the filtrate acidified with concentrated HCl, heated on the steam bath, and cooled, and the precipitate reprecipitated from the NH₄ salt gave 5.2 g. 6-NH₂ analog (XX) of XIX, m. 239-40° (decomposition). XX (30 g.) in 100 cc. H₂O and 50 cc. concentrated H₂SO₄ treated during 1.25 hrs. with stirring and cooling with 5 g. NaNO₂ in 20 cc. H₂O, the mixture stirred 1 hr., treated with H₂NSO₃H and then with 100 cc. cold 50% H₃PO₂, and stirred 10 hrs. at 0°, and the brown precipitate reprecipitated from NH₄OH gave 13.5 g. 3,2,4-AcNH(I₂)C₆H₂CO₂H (XXI), off-white, solid, m. 244-50° (decomposition), which reprecipitated from NH₄OH and recrystallized from iso-PrOH yielded 2.5 g. pure XXI, white solid, m. 264° (decomposition). VIII (44 g.) in 25 cc. concentrated HCl and 200 cc. H₂O treated during 0.5 hr. with stirring with 7 g. NaNO₂ in 20 cc. H₂O, the mixture stirred 1.5 hrs., treated with H₂NSO₃H and then with 100 cc. 50% H₃PO₂, and stirred 8 hrs. at 0°, and the resulting brown product charcoaled and reprecipitated from NH₄OH yielded 27 g. crude material which recrystallized from AcOH and reprecipitated twice from NH₄OH gave 10.5 g. 3,2,6-AcNH(I₂)C₆H₂CO₂H, m. 256° (decomposition).

Journal of the American Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gillespie, James E. published the artcileRegioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines, HPLC of Formula: 638-45-9, the publication is Journal of the American Chemical Society (2021), 143(25), 9355-9360, database is CAplus and MEDLINE.

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactive N-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the arene ortho position. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly to ortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsym., selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuable ortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

Journal of the American Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cheng, Ying published the artcileTransition metal-free 1,2-carboboration of unactivated alkenes, COA of Formula: C5H9IO2, the publication is Journal of the American Chemical Society (2018), 140(20), 6221-6225, database is CAplus and MEDLINE.

A method for transition metal-free 1,2-carboboration of unactivated alkenes with bis(catecholato)diboron as the boron source in combination with alkyl halides as the alkyl component is introduced. The three-component reaction of aryl alkenes ArX(CH₂)_nCH:CH₂ (n = 1-3; X = bond, O) with B₂cat₂ and perfluoroalkyl iodides R^FI as the photoactivated radical source proceeds via a radical pathway on a broad range of unactivated alkenes, and the 1,2-carboboration/transesterification products ArX(CH₂)_nCH(Bpin)CH₂R^F serve as valuable synthetic building blocks. D. functional theory calculations provide insights into the mechanism.

Journal of the American Chemical Society published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, COA of Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cronk, W. Cole published the artcileIntramolecular Photoassisted Cycloadditions of Azaxylylenes and Postphotochemical Capstone Modifications via Suzuki Coupling Provide Access to Complex Polyheterocyclic Biaryls, Application In Synthesis of 53279-83-7, the publication is Journal of Organic Chemistry (2014), 79(3), 1235-1246, database is CAplus and MEDLINE.

Modular preassembly of azaxylylene photoprecursors, halogen-substituted in the aromatic ring, their intramol. [4 + 4] or [4 + 2] cycloadditions to tethered unsaturated pendants, and subsequent postphotochem. capstone modification of the primary photoproducts via Suzuki coupling provides rapid access to diverse biaryls of unprecedented topol. [e.g., I �(II + III) �(IV + V)]. This synthetic sequence allows for rapid growth of mol. complexity and is well aligned with methodol. of diversity-oriented synthesis.

Journal of Organic Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Application In Synthesis of 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Fei published the artcileTransition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles with sodium trifluoromethanesulfinate in ionic liquids, Recommanded Product: 1-Iodohexane, the publication is Tetrahedron Letters (2021), 153015, database is CAplus.

An acid-promoted protocol has been developed to achieve the transition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles I (R = H, 4-Me, 5-benzyloxy, 6-F, etc.; R¹ = H, Me, Et; R² = H, Ph) using sodium trifluoromethanesulfinate in an imidazolium-based ionic liquid ([Hmim]Br) to obtain subtd. ((trifluoromethyl)thio)-1H-indole derivatives II. The [Hmim]Br not only acts as a recyclable solvent, but also as the reductant in this transformation. The advantages of this chem. include simple operation, use of a recyclable solvent, avoidance of transition-metal and phosphorus, and gram-scale synthesis.

Tetrahedron Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C9H9F5Si, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Ting-Ting published the artcileElectrochemical Alkoxyhalogenation of Alkenes with Organohalides as the Halide Sources via Dehalogenation, Quality Control of 31253-08-4, the publication is Organic Letters (2020), 22(18), 7250-7254, database is CAplus and MEDLINE.

A general, ideal atom use electrochem. technol. to enable alkene alkoxyhalogenation and organohalide dehalogenation in one pot is presented. This technol. is highlighted by convergent strategy integrating several reactions, such as alkene alkoxyhalogenation, organohalide dehalogenation, and dehalogenation deuteration. Exptl. data suggest that alkenes have the lowest oxidation potential, which lead to anodic conversion of the C=C bond to the radical cation intermediates, and cathodic transformations of organohalides, including alkyl and aryl halides, as the nucleophilic halogen sources.

Organic Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C7H7BClFO3, Quality Control of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com