Tag: M.W=200-250

Tsang, Chui-Shan published the artcileUnexpected Promotional Effects of Alkyl-Tailed Ligands and Anions on the Electrochemical Generation of Ruthenium(IV)-Oxo Complexes, SDS of cas: 638-45-9, the publication is ChemElectroChem (2021), 8(12), 2221-2230, database is CAplus.

Electro-generation of Ru^IV=O species from the RuII-aqua complex is a crucial step to excel the electrocatalytic water oxidation performance of ruthenium oxo complexes. We report herein the synthesis and X-ray crystal structural characterizations of new RuII-aqua complexes containing N-substituted 2,2′-dipyridylamine ligands (L) tagged with an alkyl chain of various lengths, [Ru(tpy)(L)(OH₂)]²⁺. Cyclic voltammetric analyses show that the length of the alkyl chain exerts great influence on the electro-generation of Ru^IV=O species. The L with a longer alkyl chain in an acidic aqueous medium promotes the conversion of Ru^III-OH to Ru^IV=O efficiently. Surprisingly, this conversion can be further enhanced by the presence of perchlorate anions. Chronocoulometric data reveal that the alkyl chain on L promotes the adsorption of the ruthenium complex on the electrode surface. Bulk electrolysis results indicate that the [Ru(tpy)(dppa)(OH₂)]²⁺ (dppa=(2,2′-dipyridyl)-n-propylamine) gives the most active electrocatalytic water oxidation activity among the ruthenium-aqua complexes investigated in this study.

ChemElectroChem published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C10H10O2, SDS of cas: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cao, Lidong published the artcilep-MeOC₆H₄N₂⁺BF₄^–/TiCl₃: a novel initiator for halogen atom-transfer radical reactions in aqueous media, Category: iodides-buliding-blocks, the publication is Tetrahedron Letters (2008), 49(52), 7380-7382, database is CAplus.

With the combination of p-methoxybenzenediazonium tetrafluoroborate with TiCl₃ as the initiator, a wide range of halogen atom-transfer radical addition or cyclization reactions could be efficiently implemented in aqueous solution at room temperature

Tetrahedron Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Zheng-Xin published the artcileCooperative Ligand-Promoted P(III)-Directed Ruthenium-Catalyzed Remote Meta-C-H Alkylation of Tertiary Phosphines, Formula: C5H9IO2, the publication is Organic Letters (2021), 23(6), 2057-2062, database is CAplus and MEDLINE.

Herein, the authors disclose a Ru-catalyzed meta-selective C-H activation of phosphines by using intrinsic P(III) as a directing group. 2,2,6,6-Tetramethylheptane-3,5-dione acts as the ligand and exhibits an excellent performance in boosting the meta-alkylation. The protocol allows an efficient and straightforward synthesis of meta-alkylated tertiary phosphines. Several meta-alkylated phosphines were evaluated for Pd-catalyzed Suzuki coupling and are superior to com. available ortho-substituted phosphines. The practicability of this methodol. is further demonstrated by the synthesis of difunctionalized phosphines.

Organic Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C6H10F3NO, Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stambirskyi, Maksym V. published the artcilePhosphine Oxides (-POMe₂) for Medicinal Chemistry: Synthesis, Properties, and Applications, Recommanded Product: 4-Iodo-1-methyl-1H-pyrazol-5-amine, the publication is Journal of Organic Chemistry (2021), 86(18), 12783-12801, database is CAplus and MEDLINE.

A general practical approach to hetero(aromatic) and aliphatic P(O)Me₂-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me₂. The P(O)Me₂ substituent was shown to dramatically increase solubility and decrease lipophilicity of organic compounds This tactic was used to improve the solubility of the antihypertensive drug prazosin without affecting its biol. profile.

Journal of Organic Chemistry published new progress about 1443278-79-2. 1443278-79-2 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Amine, name is 4-Iodo-1-methyl-1H-pyrazol-5-amine, and the molecular formula is C10H9ClN2O, Recommanded Product: 4-Iodo-1-methyl-1H-pyrazol-5-amine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Uegaki, Hiroko published the artcileLiving radical polymerization of acrylates with rhenium(V)-based initiating systems: ReO₂I(PPh₃)₂/Alkyl Iodide, Computed Properties of 31253-08-4, the publication is ACS Symposium Series (2000), 196-206, database is CAplus.

Rhenium(V) iododioxobis(triphenylphosphine) [ReO₂I(PPh₃)₂], a group 7 transition metal complex, induced living radical polymerizations of Me and Bu acrylates in conjunction with an iodide initiator such as CH₃CH(Ph)I and (CH₃)₂C(CO₂Et)I in the presence of Al(Oi-Pr)₃, where the reaction was faster than the NiBr₂(Pn-Bu₃)₂-mediated. The number-average mol. weights of the obtained polymers increased in direct proportion to monomer conversion, and the mol. weight distributions were relatively narrow throughout the polymerizations (M_w/M_n ∼ 1.6). The polymerization most probably proceeds via the rhenium-catalyzed homolytic cleavage of the polymer C-I terminal originated from the iodide initiator, as indicated by the ¹H NMR anal. of the polymer terminal structure and quenching study of the polymerization with a stable nitroxide radical. In contrast, a bromide initiator like CCl₃Br led to an uncontrolled acrylate polymerization with the rhenium(V) complex. The iodide/ReO₂I(PPh₃)₂ initiating system also induced a fast polymerization of Me methacrylate, though the polymerization was not controlled.

ACS Symposium Series published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C9H6BrNO, Computed Properties of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tatevosyan, Stepan S. published the artcileFacile Access to Triazole-Fused 3,1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C-O Coupling, Related Products of iodides-buliding-blocks, the publication is Synthesis (2022), 54(2), 369-377, database is CAplus.

A convenient approach to assemble 1,2,3-triazole-fused 4 H-3,1-benzoxazines I (R = H, 6-Me, 7-I, 7,8-dimethoxy, etc.; R¹ = H, Me, Ph; R² = Bu, cyclopropyl, Ph, etc.) has been developed. Diverse alc.-tethered 5-iodotriazoles II (R³ = H, 6-Me, 5-I, 4,5-dimethoxy, etc.), readily accessible by a modified protocol of Cu-catalyzed (3+2)-cycloaddition, were utilized as precursors of the target fused heterocycles I. The intramol. C-O coupling proceeded efficiently under base-mediated transition-metal-free conditions, furnishing cyclization products I in yields up to 96%. Suppression of the competing reductive cleavage of the C-I bond was achieved by the use of Na₂CO₃ in acetonitrile at 100°C. This practical and cost-effective procedure features a broad substrate scope and valuable functional group tolerance.

Synthesis published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C13H10F2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhuang, Zhi-Ping published the artcileBiphenyls labeled with technetium 99m for imaging β-amyloid plaques in the brain, Category: iodides-buliding-blocks, the publication is Nuclear Medicine and Biology (2005), 32(2), 171-184, database is CAplus and MEDLINE.

Formation and accumulation of excess aggregates of β-amyloid (Aβ) plaques in the brain are critical factors contributing to the development and progression of Alzheimer’s disease (AD). There is an urgent need for in vivo imaging agents that can specifically demonstrate the location and d. of Aβ plaques in the brain. The aim of this study was to develop potential technetium 99m (^99mTc)-labeled diagnostic imaging agents specific for the detection of Aβ plaques. Based on previously obtained Aβ plaque-specific biphenyls containing a p-N, N-dimethylaminophenyl group, a series of ^99mTc and Re-N₂S₂-biphenyl derivatives was prepared The stable neutral and lipophilic ^99mTc complexes, [^99mTc]19 and [^99mTc]23, A+B, were successfully obtained. As surrogates for the ^99mTc complexes, the corresponding surrogates, Re complexes of 23, were also prepared Surprisingly, it was found that the Re complexes showed distinctively different retention profiles as compared with the corresponding ^99mTc complexes. Biodistribution studies indicated that [^99mTc]23A readily passed through the blood-brain barrier (1.18% dose/brain at 2 min) in contrast to the low brain penetration of [^99mTc]19 (0.29% dose/brain at 2 min). Initial results suggested that [^99mTc]23A showed selective binding to the Aβ plaque-like structures in the brain sections from transgenic mice but not in the postmortem human brain tissue of patients with confirmed AD. The results provide encouraging evidence that development of a ^99mTc-labeled agent for imaging Aβ plaques in the brain may be feasible. Caution should be taken when comparing these ^99mTc complexes with the corresponding surrogates – the Re complexes.

Nuclear Medicine and Biology published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C8H10S, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhuang, Zhi-Ping published the artcileSyntheses of two potential ligands for Tc-99m labeling as diagnosis agents of Alzheimer’s disease, Formula: C7H8INO, the publication is Chinese Journal of Chemistry (2003), 21(7), 824-832, database is CAplus.

Two ligands, I and II, which can be labeled with Tc-99m for the diagnosis of Alzheimer’s disease (AD) have been synthesized. The key steps in these two syntheses involved Suzuki and Wittig reactions, resp. A newly discovered debromination reaction may be extended to compounds with a double or triple bond adjacent to the carbon atom bearing the bromine atoms. These syntheses provide a route to biphenyl and stilbene derivatives that will benefit the search of new imaging agents for AD.

Chinese Journal of Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C14H7F3OS, Formula: C7H8INO.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Imamoto, Tsuneo published the artcileCarbon-carbon bond-forming reactions using cerium metal or organocerium(III) reagents, HPLC of Formula: 31253-08-4, the publication is Journal of Organic Chemistry (1984), 49(21), 3904-12, database is CAplus.

Cerium amalgam is an effective reagent for the chemoselective preparation of homoallylic alcs. from allyl halides and carbonyl compounds and for the Reformatskii-type reaction of α-halo esters with carbonyl compounds Organocerium(III) reagents were conveniently generated by the reaction of organolithiums with CeI₃ or CeCl₃ and they react cleanly at -78 to -65° with various carbonyl compounds to afford the addition products in high yields. The substrates are susceptible to enolization or metal-halogen exchange with simple organolithiums. The same reagents also react with α,β-unsaturated carbonyl compounds to yield 1,2-addition products in high selectivity.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kwun, Oh Cheun published the artcileThe thermodynamics of the formation of pyridine-halogen and interhalogen charge transfer complexes, Application In Synthesis of 6443-90-9, the publication is Taehan Hwahakhoe Chi (1982), 26(6), 363-8, database is CAplus.

UV spectra of systems of pyridine with iodine, iodine monobromide and iodine monochloride in CCl₄ reveal the formation of 1:1 complexes C₅H₅N·I₂, C₅H₅N·IBr and C₅H₅N·ICl. Equilibrium constants and thermodn. parameters were obtained. The relative stabilities of the complexes increase in the order given. This may be a measure of relative acidities of halogen and interhalogens toward pyridine and can be explained by the polarizabilities of electron acceptors and the difference of electronegativities of the halogen atoms.

Taehan Hwahakhoe Chi published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Application In Synthesis of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com