Tag: M.W=200-250

Sun, Zhenhua published the artcileSyntheses of Pyridine C-Nucleosides as Analogues of the Natural Nucleosides dC and dU, Safety of 6-Fluoro-5-iodopyridin-2-ol, the main research area is hydrogen bond pyridine nucleoside synthesis palladium catalyst coupling; pyridine C nucleoside synthesis Heck palladium catalyst coupling.

The syntheses of four pyrimidine C-nucleosides are described. These derivatives are designed as mimics of dC and dU, and in that respect, each can form two hydrogen bonds with complementary dG or dA residues. The minor groove O2 carbonyl in each derivative is replaced by a fluorine or a Me group. The key carbon-carbon bond connecting the heterocycle to the carbohydrate is formed using a Heck-type palladium-mediated coupling reaction.

Journal of Organic Chemistry published new progress about Coupling reaction. 884660-48-4 belongs to class iodides-buliding-blocks, name is 6-Fluoro-5-iodopyridin-2-ol, and the molecular formula is C5H3FINO, Safety of 6-Fluoro-5-iodopyridin-2-ol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schlosser, Manfred published the artcileThe reactivity of 2-fluoro- and 2-chloropyridines toward sodium ethoxide: Factors governing the rates of nucleophilic (het)aromatic substitutions, Synthetic Route of 685517-67-3, the main research area is reactivity fluoropyridine chloropyridine sodium ethoxide nucleophilic aromatic heteroaromatic substitution.

The relative displacement rates of the halide substituent from 2-fluoro- and 2-chloropyridines by EtONa in EtOH at +25° were assessed by competition kinetics. The 2-fluoropyridine reacts 320 times faster than the chloro analog. A CF3 group increases the reactivity more than single halogen atoms do, whatever the element, and the latter are superior to Me3Si groups. Substituents accommodated at the 4-position operate through their inductive effect, whereas at the 3-position, this action may be attenuated by steric hindrance. Almost all 5-substituents enhance the rate of the nucleophilic substitution occurring at the 2-position. The sole exception concerns the F-atom at the 5-position which retards the reaction, presumably by lone-pair/lone-pair repulsion with the neg. charge building up at the central C-atom of the intermediate Meisenheimer complex. The substituent effects are additive. Therefore, by using the increments derived from the present work, the rates of future reactions should be predictable with fair accuracy.

Helvetica Chimica Acta published new progress about Ethoxylation kinetics. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, Synthetic Route of 685517-67-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yibiao published the artcile2-Acetylthienopyridine Synthesis via Thiolation and Copper-Catalyzed Cyclization of o-Propynol Fluoropyridine Using Xanthate as a Thiol Surrogate, SDS of cas: 153034-78-7, the main research area is fluoropyridinylalkynol xanthate thiolation cyclization oxidation copper; thienopyridine preparation; copper thiolation cyclization oxidation catalyst.

2-Acylthienopyridines and related heterocycles are readily prepared in moderate to good yields under mild conditions by a nucleophilic thiolation, copper-catalyzed cyclization, and an oxidation cascade process using potassium xanthate as the thiol source. Moreover, excellent chemoselectivity, broad substrate scope, and good functional group tolerance are prominent features of this transformation.

Journal of Organic Chemistry published new progress about Cyclization. 153034-78-7 belongs to class iodides-buliding-blocks, name is 2-Fluoro-3-iodo-5-methylpyridine, and the molecular formula is C6H5FIN, SDS of cas: 153034-78-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xia, Guoqin published the artcileLigand-Enabled β-Methylene C(sp3)-H Arylation of Masked Aliphatic Alcohols, SDS of cas: 685517-67-3, the main research area is methylene arylation aliphatic alc salicylic directing group pyridone ligand; C−H activation; aliphatic alcohols; directing groups; ligands; synthetic methods.

Despite recent advances, reactivity and site-selectivity remain significant obstacles for the practical application of C(sp3)-H bond functionalization methods. Here, we describe a system that combines a salicylic-aldehyde-derived L,X-type directing group with an electron-deficient 2-pyridone ligand to enable the β-methylene C(sp3)-H arylation of aliphatic alcs., which has not been possible previously. Notably, this protocol is compatible with heterocycles embedded in both alc. substrates and aryl coupling partners. A site- and stereo-specific annulation of dihydrocholesterol and the synthesis of a key intermediate of englitazone illustrate the practicality of this method.

Angewandte Chemie, International Edition published new progress about Arylation. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, SDS of cas: 685517-67-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schlosser, Manfred published the artcileThe reactivity of 2-fluoro- and 2-chloropyridines toward sodium ethoxide: Factors governing the rates of nucleophilic (het)aromatic substitutions, Synthetic Route of 685517-67-3, the main research area is reactivity fluoropyridine chloropyridine sodium ethoxide nucleophilic aromatic heteroaromatic substitution.

The relative displacement rates of the halide substituent from 2-fluoro- and 2-chloropyridines by EtONa in EtOH at +25° were assessed by competition kinetics. The 2-fluoropyridine reacts 320 times faster than the chloro analog. A CF3 group increases the reactivity more than single halogen atoms do, whatever the element, and the latter are superior to Me3Si groups. Substituents accommodated at the 4-position operate through their inductive effect, whereas at the 3-position, this action may be attenuated by steric hindrance. Almost all 5-substituents enhance the rate of the nucleophilic substitution occurring at the 2-position. The sole exception concerns the F-atom at the 5-position which retards the reaction, presumably by lone-pair/lone-pair repulsion with the neg. charge building up at the central C-atom of the intermediate Meisenheimer complex. The substituent effects are additive. Therefore, by using the increments derived from the present work, the rates of future reactions should be predictable with fair accuracy.

Helvetica Chimica Acta published new progress about Ethoxylation kinetics. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, Synthetic Route of 685517-67-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yibiao published the artcile2-Acetylthienopyridine Synthesis via Thiolation and Copper-Catalyzed Cyclization of o-Propynol Fluoropyridine Using Xanthate as a Thiol Surrogate, SDS of cas: 153034-78-7, the main research area is fluoropyridinylalkynol xanthate thiolation cyclization oxidation copper; thienopyridine preparation; copper thiolation cyclization oxidation catalyst.

2-Acylthienopyridines and related heterocycles are readily prepared in moderate to good yields under mild conditions by a nucleophilic thiolation, copper-catalyzed cyclization, and an oxidation cascade process using potassium xanthate as the thiol source. Moreover, excellent chemoselectivity, broad substrate scope, and good functional group tolerance are prominent features of this transformation.

Journal of Organic Chemistry published new progress about Cyclization. 153034-78-7 belongs to class iodides-buliding-blocks, name is 2-Fluoro-3-iodo-5-methylpyridine, and the molecular formula is C6H5FIN, SDS of cas: 153034-78-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. COA of Formula: C6H6IN.

Zhang, Yuyan;Shamzhy, Mariya;Kubu, Martin;Cejka, Jiri research published 《 Nanosponge hierarchical micro-mesoporous MFI zeolites as a high-performance catalyst for the hydroamination of methyl acrylate with aniline》, the research content is summarized as follows. Zeolites catalyze the hydroamination of alkenes, alkynes and dienes, yielding valuable amines, enamines and imines with high efficiency and chemoselectivity (i.e., Markovnikov or anti-Markovnikov products) thanks to the architecture of their pore system and tunable acidity. However, their micropores may impose mass-transfer constraints on reaction rates. Nevertheless, the high external surface area of hierarchical micro-mesoporous zeolites should enable them to outperform conventional zeolites. To test our hypothesis, we compared the activity of hierarchical MFI zeolites of different crystal morphologies (i.e., nanosponge, nanosheet and microcrystalline desilicated samples) with that of conventional medium- (MFI) and large-pore (MOR and Beta) zeolites in the hydroamination of Me acrylate with aniline. The results showed that nanosponge MFI had the highest activity (TOF = 32.9 h^-1), reaching 57% yield of the anti-Markovnikov product N-[2-(methoxycarbonyl)ethyl]aniline. Furthermore, our kinetic study revealed a pseudo-second-order rate law with respect to aniline over the most active nanosponge MFI catalyst, with an apparent activation energy of 68.9 kJ/mol. The high external surface of this catalyst (371 m²/g) and its developed inter-crystalline mesopores (4.8 nm) suggest a kinetic-driven hydroamination reaction. Therefore, hierarchical nanosponge aluminosilicate MFI zeolites stand out as promising heterogeneous catalysts of hydroamination reactions involving bulky substrates.

626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., COA of Formula: C6H6IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Reference of 626-01-7.

Zhao, Bin;Hammond, Gerald B.;Xu, Bo research published 《 Modulation of photochemical oxidation of thioethers to sulfoxides or sulfones using an aromatic ketone as the photocatalyst》, the research content is summarized as follows. An eco-friendly and chemo-selective photocatalytic synthesis of sulfoxides, e.g., 2-(methylsulfinyl)quinoline or sulfones, e.g., 2-(methylsulfonyl)quinoline via oxidation of sulfides, e.g., 2-(methylthio)quinoline (thioethers) at ambient temperature using air or O₂ as the oxidant has been described. An inexpensive thioxanthone was used as the photocatalyst. This method offers excellent chem. yields and good functional group tolerance. The hydrogen bonding between hexafluoro-2-propanol (HFIP) and sulfoxides may play an important role in minimizing the over-oxidization of sulfoxides.

Reference of 626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Electric Literature of 1120-90-7.

Zhao, Lei;Yang, Hongyi;Li, Ruikun;Tao, Ye;Guo, Xiao-Feng;Anderson, Edward A.;Whiting, Andrew;Wu, Na research published 《 Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water》, the research content is summarized as follows. Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant.

1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., Electric Literature of 1120-90-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Name: 2-Iodopyridine.

Zhao, Zesheng;Wang, Jie;Zhang, Xiaoli;Lin, Taofeng;Ren, Jianwei;Pang, Wan research published 《 Pd nanoparticles embedded into MOF-808: An efficient and reusable catalyst for Sonogashira and Heck cross-coupling reactions》, the research content is summarized as follows. In this work, the Pd@MOF-808 composite was prepared to effectively catalyze the Sonogashira and Heck reactions without the presence of organic phosphine ligands. The results showed that the developed catalyst provided an environment-friendly reaction condition for these two reactions with the existence of a variety of functional groups and substrates. In addition, the Pd@MOF-808 catalyst could be easily recovered and reused for up to 5 times with less deterioration of catalytic performance.

Name: 2-Iodopyridine, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com