Tag: M.W=200-250

Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. Recommanded Product: 3-Iodoaniline.

Qian, Mingcheng;Jiang, Xinyu;Zhang, Mingting;Hu, Lijuan;Liu, Huimin;Zhao, Shuai;Zhou, Xiaoying;Chen, Xin research published 《 Synthesis, Biological Evaluation, and Docking Study of Ring-Opening Amide Analogs of Matrine as Antitumor Agents》, the research content is summarized as follows. In this article, we designed and synthesized two series of matrine analogs with ring-opening in the lactam portion of the mol. Our in vitro cytotoxicity study showed that analog N-(3-bromophenyl)-4-[(1R,3aS,10aR,10bS)-decahydro-1H,4H-pyrido[3,2,1-ij][1,6]naphthyridin-1-yl]butanamide (I) with a meta-bromide on the Ph ring displayed the best antiproliferative activity. Moreover, I induced cell cycle arrest in G1 phase and cell apoptosis in a dose-dependent manner in A549 cells. Mol. modeling revealed that I achieved a higher docking score compared to its precursor tert-Bu (1R,3aS,10aR,10bS)-1-[4-(3-bromoanilino)-4-oxobutyl]octahydro-1H,4H-pyrido[3,2,1-ij][1,6]naphthyridine-2(3H)-carboxylate (II) and parent compound matrine, possibly because I formed a hydrogen bond with SER91 and a halogen bond with GLN320 on the binding site of annexin A2. Overall, we discovered the potential anticancer lead compound I, which can be used for further study both in vitro and in vivo.

626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., Recommanded Product: 3-Iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Synthetic Route of 626-01-7.

Qu, Zhonghua;Chen, Xing;Zhong, Shuai;Deng, Guo-Jun;Huang, Huawen research published 《 NaI/PPh₃-Mediated Photochemical Reduction and Amination of Nitroarenes》, the research content is summarized as follows. A mild transition-metal- and photosensitizer-free photoredox system based on the combination of NaI and PPh₃ was found to enable highly selective reduction of nitroarenes. This protocol tolerated a broad range of reducible functional groups such as halogen (Cl, Br and even I), aldehyde, ketone, carboxyl and cyano. Moreover, the photoredox catalysis with NaI and stoichiometric PPh₃ provides also an alternative entry to Cadogan-type reductive amination when o-nitrobiarenes were used.

Synthetic Route of 626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Safety of 3-Iodoaniline.

Rafiee, F.;Rezaee, M. research published 《 Catalytic reduction of nitroarenes and degradation of dyes at room temperature by an efficient NNN pincer palladium catalyst based on the magnetic amino-triazole-modified chitosan》, the research content is summarized as follows. In this study, a magnetic chitosan biosupport was synthesized and functionalized with a NNN pincer ligand to facilitate palladium immobilization. FT-IR, FE-SEM, EDX, XRD, VSM, ICP, BET, and TGA analyses were used to characterize the synthesized nanocomposite (Fe₃O₄@Triazole-CS@NNN-Pd). Then, its catalytic activity in the reduction of a wide variety of nitroarom. compounds at room temperature was investigated using sodium borohydride as a reducing agent, as well as the degradation of three hazardous dyes, including Methylene Blue (MB), Methyl orange (MO), and Rhodamine B (RhB). This technique is feasible due to its ease of purification, environmental friendliness, and high yield of product generation in a relatively short response time. The nanocatalyst is easily separated, recovered, and reused for numerous cycles without significantly degrading catalytic activity.

626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., Safety of 3-Iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. HPLC of Formula: 1120-90-7.

Ramadan, Doaa R.;Ferretti, Francesco;Ragaini, Fabio research published 《 Catalytic reductive cyclization of 2-nitrobiphenyls using phenyl formate as CO surrogate: A robust synthesis of 9H-carbazoles》, the research content is summarized as follows. A palladium/phenanthroline catalyzed reductive cyclization of o-nitrobiphenyls to 9H-carbazoles operated by in situ released CO is described. In the present method, the presence of Ph formate is essential to avoid the use of high-pressure equipment and allows to perform the reaction in a single thick-walled glass tube. The identity of the base, which catalyzes the formate decomposition, is crucial to the selectivity of the reaction. Stability of the catalyst is influenced by the presence of chloride anions. Carbazole yields are most often higher than those previously reported using pressurized CO. The optimized catalytic system features excellent stability and moisture and air tolerance allowing to perform the reaction with low catalyst loadings.

HPLC of Formula: 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. HPLC of Formula: 626-01-7.

Nasresfahani, Zahra;Kassaee, Mohamad Z. research published 《 Bimetallic Ni/Cu mesoporous silica nanoparticles as an efficient and reusable catalyst for the Sonogashira cross-coupling reactions》, the research content is summarized as follows. A bimetallic mesoporous system (Ni/Cu-MCM-41) had been developed and evaluated as an efficient catalyst for the Sonogashira cross-coupling reaction, under palladium-free conditions. In this new methodol., a wide range of aryl halides react with phenylacetylene to gave the corresponding disubstituted alkynes RC≡CAr [Ar = Ph; R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, etc.] in good yields. Moreover, the present catalytic system was desired because of its high efficiency, easy preparation, low cost, high activity and good recyclability.

HPLC of Formula: 626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Reference of 1120-90-7.

Niakan, Mahsa;Masteri-Farahani, Majid research published 《 An efficient clean and sustainable methodology for catalytic C-C coupling process over a Pd-free magnetically recoverable cobalt catalyst》, the research content is summarized as follows. The Suzuki and Sonogashira coupling reactions are important processes in organic synthesis. However, to date, these reactions have been extensively examined using Pd-based catalysts in toxic organic solvents. Therefore, developing clean and inexpensive methodologies for these reactions remained a major challenge. Herein, by taking the advantages of thiol-ene click reaction, an easy and robust strategy for surface modification of magnetic graphene oxide with a dendrimer structure was successfully developed. Dendrimer-functionalized magnetic graphene oxide was then applied for the immobilization of Co nanoparticles. Transmission electron microscopy exhibited a homogeneous distribution of Co nanoparticles with the size of about 3 nm. The resultant nanocomposite revealed high efficiency in catalytic Suzuki and Sonogashira reactions in non-hazardous and sustainable deep eutectic solvents (DESs). The DES and catalyst were simply recycled five times with gradual slight decrease in the yield of the reactions. More importantly, the catalyst was magnetically isolated at the end of the recycling process. Overall, the utilization of DES as an environmentally friendly and recoverable reaction medium, as well as replacing the low-cost cobalt catalyst as an alternative to expensive Pd catalyst along with the facile catalyst isolation by employing an external magnetic field, make the present protocol promising from economic and green chem. points of view for the clean C-C coupling reactions.

1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., Reference of 1120-90-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Category: iodides-buliding-blocks.

Niu, Zhi-Jie;Li, Lian-Hua;Li, Xue-Song;Liu, Hong-Chao;Shi, Wei-Yu;Liang, Yong-Min research published 《 Formation of o-Allyl- and Allenyl-Modified Amides via Intermolecular Claisen Rearrangement》, the research content is summarized as follows. A new transition-metal-free intermol. Claisen rearrangement process introduced allyl and allenyl groups into the α position of tertiary amides. In this transformation, amides were activated by trifluoromethanesulfonic anhydride to produce the keteniminium ion intermediates that exhibit strong electrophilic activity. This atom-economical process delivers α position-modified amides under mild conditions in moderate to good yields and showcased a broad substrate compatibility.

5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Reference of 1120-90-7.

Obradors, Carla;List, Benjamin research published 《 Azine Activation via Silylium Catalysis》, the research content is summarized as follows. A direct, catalytic and selective functionalization of azines via silylium activation was described. The catalyst design enabled mild conditions and a remarkable functional group tolerance in a one-pot setup.

Reference of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Recommanded Product: 3-Iodoaniline.

Oekchuae, Sittisak;Sirirak, Jitnapa;Charoensuksai, Purin;Wongprayoon, Pawaris;Chuaypen, Natthaya;Boonsombat, Jutatip;Ruchirawat, Somsak;Tangkijvanich, Pisit;Suksamrarn, Apichart;Limpachayaporn, Panupun research published 《 The Design and Synthesis of a New Series of 1,2,3-Triazole-Cored Structures Tethering Aryl Urea and Their Highly Selective Cytotoxicity toward HepG2》, the research content is summarized as follows. Herein, a new series of 1,2,3-triazole-cored structures incorporating aryl urea I [R = H, 2-Me, 4-F, etc.] as anti-HepG2 agents was designed and synthesized via nucleophilic addition and copper-catalyzed azide-alkyne cycloaddition (CuAAC) with excellent yields. Significantly, almost all triazole-cored analogs exhibited less cytotoxicity toward normal cells, human embryonal lung fibroblast cell MRC-5, compared to Sorafenib and Doxorubicin. Among them, I [R = 2-OEt, 2-Cl] exhibited the highest selectivity indexes (SI = 14.7 and 12.2), which were ca. 4.4- and 3.7-fold superior to that of Sorafenib (SI = 3.30) and ca. 3.8- and 3.2-fold superior to that of Doxorubicin (SI = 3.83), resp. Addnl., excellent inhibitory activity against hepatocellular carcinoma HepG2, comparable to Sorafenib, was still maintained. A cell-cycle anal. and apoptosis induction study suggested that I [R = 2-OEt, 2-Cl] likely share a similar mechanism of action to Sorafenib. Furthermore, compounds I [R = 2-OEt, 2-Cl] exhibit appropriate drug-likeness, analyzed by SwissADME. With their excellent anti-HepG2 activity, improved selectivity indexes, and appropriate druggability, the triazole-cored analogs I [R = 2-OEt, 2-Cl] are suggested to be promising candidates for development as targeted cancer agents and drugs used in combination therapy for the treatment of HCC.

Recommanded Product: 3-Iodoaniline, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Recommanded Product: 3-Iodoaniline.

Okamoto, Kazuhiro;Ishikawa, Aoi;Okawa, Ryotaro;Yamamoto, Kazuki;Sato, Toyotaka;Yokota, Shin-ichi;Chiba, Kazuhiro;Ichikawa, Satoshi research published 《 Design, synthesis and biological evaluation of simplified analogues of MraY inhibitory natural product with rigid scaffold》, the research content is summarized as follows. Muraymycins and caprazamycins are strong inhibitors of MraY, which is responsible for peptidoglycan biosynthesis. Although they are promising antibacterial agents with a novel mode of action, their chem. structures are rather complex. This study investigated the simplification of these natural products by structure-based drug design, synthesis, and biol. evaluation. We developed a simplified rigid scaffold with an arylalkyne moiety, which shows sub-micromolar MraY inhibitory activity. The scaffold is suitable for further investigating the structure-activity relationship by virtue of our synthetic strategy, where the substituent of interest is installed in the last stage of synthesis. This scaffold shows the potential for further use in optimizing MraY inhibitory and antibacterial activities.

626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., Recommanded Product: 3-Iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com